Glabrene | 60008-03-9

• 物质功能分类: 生物化工 - 中草药成分
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: Glabrene
• 英文别名: 6-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethylchromen-5-ol
• CAS: 60008-03-9
• 化学式: C₂₀H₁₈O₄
• 分子量: 322.361
• InChiKey: KKLOCFOZPFGVBB-UHFFFAOYSA-N

物化性质

• 沸点：
  536.3±50.0 °C(Predicted)
• 密度：
  1.293±0.06 g/cm3(Predicted)
• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2905399090
• 储存条件：
  2-8℃，干燥，密封保存。

制备方法与用途

概述

光甘草素又名光果甘草素，是豆科植物光甘草根的主要有效成分。它是一种淡黄色粉末，不溶于水，但可溶于甲醇、乙醇和乙醚。现代研究表明，光甘草素具有清除超氧离子、抑制酪氨酸酶及类雌激素样作用等多种药理活性。尽管目前尚未有文献报道光甘草素具有显著的抗癌效果。

作用

光甘草素能够抑制HepaRG和Caco2细胞增殖，其机制可能与其诱导细胞凋亡及G2/M期阻滞有关。

生物活性

Glabrene 是一种异黄酮类化合物，来源于甘草根部，具有类似雌激素的生物活性。研究表明，Glabrene 对酪氨酸酶有抑制作用，IC50值为3.5 μM。

靶点

• IC50: 3.5 μM (Tyrosinase)

文献信息

• NOVEL SUGAR DERIVATIVE GELATORS
  申请人：KYUSHU UNIVERSITY

  公开号：US20180208618A1

  公开（公告）日：2018-07-26

  A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): wherein R 1 is a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group having a carbon atom number of 13 to 20, or a linear or branched alkenyl group having a carbon atom number of 9 to 20, R 2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R 3 and R 4 are hydroxy groups.

  一种包括糖衍生物的新型凝胶剂；一种包括化合物Formula（1）或Formula（2）的凝胶剂：其中，R1是具有碳原子数为9至20的直链或支链烷基基团，具有碳原子数为13至20的环烷基基团，或具有碳原子数为9至20的直链或支链烯基基团，R2是氢原子，具有碳原子数为1至10的直链或支链烷基基团，或具有取代基的芳基基团，而R3和R4是羟基。
• NICOTINYL RIBOSIDE COMPOUNDS AND THEIR USES
  申请人：MitoPower, LLC

  公开号：US20200397807A1

  公开（公告）日：2020-12-24

  The disclosure provides nicotinamide riboside (NR), the reduced form of NR (NRH), nicotinic acid riboside (NAR), the reduced form of NAR (NARH), derivatives thereof, compositions thereof and uses thereof. The NR and NAR derivatives have improved stability and bioavailability compared to NR and NAR. NR, NRH, NAR, NARH, and derivatives thereof can increase cellular NAD + levels and enhance mitochondrial and cellular function and cell viability. Therefore, NR, NRH, NAR, NARH, and derivatives thereof, whether alone or in combination with one or more additional therapeutic agents (e.g., a mitochondrial uncoupler or/and a PARP inhibitor), are useful for treating mitochondrial diseases, mitochondria-related diseases and conditions, metabolic disorders, and other disorders and conditions.

  该披露提供烟酰胺核糖苷（NR）、烟酰胺核糖苷的还原形式（NRH）、烟酸核糖苷（NAR）、烟酸核糖苷的还原形式（NARH）、以及它们的衍生物、组合物和用途。与NR和NAR相比，NR和NAR的衍生物具有更好的稳定性和生物利用度。NR、NRH、NAR、NARH和它们的衍生物可以增加细胞NAD+水平，增强线粒体和细胞功能以及细胞存活能力。因此，NR、NRH、NAR、NARH和它们的衍生物，无论是单独使用还是与一个或多个额外治疗剂（例如线粒体解耦蛋白抑制剂和/或PARP抑制剂）结合使用，都可用于治疗线粒体疾病、与线粒体相关的疾病和症状、代谢紊乱以及其他疾病和症状。
• METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE
  申请人：Moazed Kambiz Thomas

  公开号：US20110280909A1

  公开（公告）日：2011-11-17

  Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are nanoparticle compositions for lightening the pigmented tissues or treating a pigmented tissue related disease.

  描述了一种快速和可持续改变虹膜基质黑色素含量的黑色素细胞的方法和系统，从而改变眼睛的颜色。还描述了用于淡化有色组织或治疗有色组织相关疾病的纳米颗粒组合物。
• [EN] A MANUFACTURING PROCESS OF ISOFLAVAN OR ISOFLAVENE DERIVATIVES<br/>[FR] PROCEDE DE PRODUCTION DE DERIVES D'ISOFLAVANE OU D'ISOFLAVENE
  申请人：BICBIO CO LTD

  公开号：WO2005037815A1

  公开（公告）日：2005-04-28

  The present invention relates to a method of synthesizing isoflavan and isoflavene derivatives of the Formula 1, which have the biological efficacy of antioxidation and protection against ultraviolet light. The method is effective and suitable for a mass production of isoflavan and isoflavene derivatives, which is a more convenient alternative preparation method compared to the isolation method by the extraction of plants, such as licorice, via troublesome preparative processes.

  本发明涉及一种合成具有抗氧化和抗紫外线保护生物效应的Formula 1的异黄酮和异黄素衍生物的方法。该方法对于大规模生产异黄酮和异黄素衍生物是有效的和适用的，相比于通过植物提取（如甘草）的难以操作的制备过程，这是一种更为方便的替代制备方法。
• SKIN AGING INHIBITOR AND CONCENTRATE OF RESVERATROL 3-O-A-GLUCOSIDE
  申请人：EZAKI GLICO KABUSHIKI KAISHA

  公开号：US20170035674A1

  公开（公告）日：2017-02-09

  An object of the present invention is to provide an anti-skin aging agent that can prevent skin aging such as spots, dullness, wrinkles, sags, and skin roughness. It has been found that resveratrol 3-O-α-glucoside has remarkable anti-skin aging effects such as melanogenesis suppression, hyaluronidase inhibition, anti-oxidization, cell activation, sirtuin gene activation, matrix metalloproteinase suppression, and anti-inflammation, and thus, can be used as an anti-skin aging agent.

  本发明的目的是提供一种抗皮肤老化剂，可以预防皮肤老化，如斑点，暗沉，皱纹，下垂和皮肤粗糙等。发现白藜芦醇3-O-α-葡萄糖苷具有显着的抗皮肤老化效果，如黑色素生成抑制，透明质酸酶抑制，抗氧化，细胞活化，sirtuin基因激活，基质金属蛋白酶抑制和抗炎作用，因此可以用作抗皮肤老化剂。