ascorbyl palmitate | 137-66-6

• 物质功能分类: 食品添加剂 - 营养强化剂 - 维生素类
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ascorbyl palmitate
• 英文别名: Pharmakon1600-01505742；[2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] hexadecanoate
• CAS: 137-66-6
• 化学式: C₂₂H₃₈O₇
• 分子量: 414.54
• InChiKey: QAQJMLQRFWZOBN-FBLFFUNLSA-N

物化性质

• 熔点：
  115-118 °C(lit.)
• 比旋光度：
  +21～+26°(20℃/D, c=2, C2H5OH)
• 沸点：
  512.7±50.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)
• 溶解度：
  微溶于乙醇。
• LogP：
  6.5 at 30℃ and pH1.9

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  29
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 安全说明：
  S26,S36
• 危险类别码：
  R20/21/22
• WGK Germany：
  1
• 海关编码：
  2932190090
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  CI7671040
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

制备方法与用途

L-抗坏血酸棕榈酸酯是一种常用的抗氧化剂和食品营养强化剂。以下是关于它的详细介绍：

化学性质

1. 外观：白色或黄白色粉末。
2. 气味：略有柑橘气味。
3. 溶解性：
   • 极易溶于水和植物油。
   • 易溶于乙醇（1g/4.5ml）。
4. 熔点：107～117℃。

用途

1. 抗氧化剂：用于含油脂食品、方便面、食用油脂和氢化植物油，最大使用量为0.2g/kg；也可用于婴儿配方食品（以脂肪中抗坏血酸计），最大使用量为0.01g/kg。
2. 营养强化剂：广泛应用于食品饮料等领域。

生产方法

1. 第一种方法：

   • 将64克棕榈酸置于加热滴液漏斗，使其处于熔融状态；
   • 200毫升二氯亚砜装入烧瓶中，加热使其蒸汽通过导管进入瓷环填料的反应柱与棕榈酸反应；
   • 反应30分钟后，常压蒸馏除去少量二氯亚砜，减压蒸馏收集150～152℃（2~3kPa）无色透明液体58.6g。

2. 第二种方法：

   • 在烧瓶中加入26.5毫升二甲基甲酰胺，通入HCl气体2克；
   • 加入9.69克结晶抗坏血酸和13.3毫升二氯甲烷使反应液澄清；
   • 慢慢滴加15.2毫升棕榈酰氯，反应18小时后升温至20℃反应30分钟。
   • 将反应物加入到乙酸乙酯和水中搅拌洗涤2小时，抽滤并用水（50ml×3）洗涤3次，在50℃下真空干燥18小时，得白色粉末17.5g。

应用领域

L-抗坏血酸棕榈酸酯广泛应用于食品、医药等领域。作为营养强化剂和抗氧化保鲜剂，它对保持食品安全和营养价值具有重要作用。

文献信息

• Wavelength conversion member, backlight unit including wavelength conversion member, and liquid crystal display device
  申请人：FUJIFILM Corporation

  公开号：US10273408B2

  公开（公告）日：2019-04-30

  A wavelength conversion member is provided. The wavelength conversion member includes: a wavelength conversion layer including at least one kind of quantum dots that are excited by excitation light to emit fluorescence and an antioxidant; at least one interposing layer that is formed to be adjacent to the wavelength conversion layer; and a barrier layer that is formed on at least one surface of the wavelength conversion layer, in which at least one layer of the interposing layers is an antioxidant-containing interposing layer including the antioxidant.

  提供了一种波长转换部件。该波长转换部件包括：波长转换层，包括至少一种被激发光激发发出荧光的量子点和抗氧化剂；至少一个中间层，形成为与波长转换层相邻；以及阻挡层，形成于波长转换层的至少一个表面上，其中至少一层中间层是含抗氧化剂的中间层，包括抗氧化剂。
• A METHOD FOR TREATING AND CONTROLLING POST-HARVEST PHYSIOLOGICAL DISORDERS IN FRUIT VIA EDIBLE COATINGS
  申请人：Decco Worldwide Post-Harvest Holdings B.V.

  公开号：EP3684177A1

  公开（公告）日：2020-07-29
• CRYSTAL FORMS OF APOMORPHINE AND USES THEREOF
  申请人：NeuroDerm, Ltd.

  公开号：US20170368052A1

  公开（公告）日：2017-12-28

  The present invention provides solid crystalline forms of apomorphine free base or a hydrate, solvate, or co-crystals thereof. Such crystalline forms may be advantageous over amorphous forms of apomorphine, e.g., amorphous salt forms such as acid addition salts of apomorphine, because of their increased/greater stability and/or improved pharmacological properties, e.g., decreased adverse reactions at the site of administration. The invention further provides liquid formulations obtained by dissolving said crystalline forms of apomorphine in a solvent, as well as a method for treatment of a neurological or movement disorder, e.g., Parkinson's disease, or a condition associated therewith, by administration of said liquid formulations.
• WAVELENGTH CONVERSION MEMBER, BACKLIGHT UNIT INCLUDING WAVELENGTH CONVERSION MEMBER, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20180072949A1

  公开（公告）日：2018-03-15

  A wavelength conversion member is provided. The wavelength conversion member includes: a wavelength conversion layer including at least one kind of quantum dots that are excited by excitation light to emit fluorescence and an antioxidant; at least one interposing layer that is formed to be adjacent to the wavelength conversion layer; and a barrier layer that is formed on at least one surface of the wavelength conversion layer, in which at least one layer of the interposing layers is an antioxidant-containing interposing layer including the antioxidant.
• [EN] A METHOD FOR TREATING AND CONTROLLING POST-HARVEST PHYSIOLOGICAL DISORDERS IN FRUIT VIA EDIBLE COATINGS<br/>[FR] PROCÉDÉ DE TRAITEMENT ET DE LUTTE CONTRE DES TROUBLES PHYSIOLOGIQUES POST-RÉCOLTE DANS DES FRUITS PAR L'INTERMÉDIAIRE DE REVÊTEMENTS COMESTIBLES
  申请人：DECCO WORLDWIDE POST HARVEST HOLDINGS B V

  公开号：WO2019058211A1

  公开（公告）日：2019-03-28

  The present invention describes the method for treating and controlling physiological disorders that are caused during the post-harvest process of fruit, which comprises the application of an aqueous solution which is a edible coating and said coating comprising at least one phospholipid, or at least one polysorbate, or at least a sorbitan ester, or at least a sucrose ester of fatty acids or at least a sucroglyceride of fatty acids or a combination thereof the application being during any one of the stages of the post-harvest process to their shipment and sale at their final destination.