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    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-[4-(diethylamino)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C30H34N6O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-[4-(diethylamino)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dichlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H23Cl2N5O2
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dichlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(3,5-difluorophenyl)-2-[(3R)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H19F2N5O2
    (5R,6S)-5-(3,5-difluorophenyl)-2-[(3R)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-[(3S)-3-methylpiperidin-1-yl]-5-(3-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20N6O4
    (5R,6S)-2-[(3S)-3-methylpiperidin-1-yl]-5-(3-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(3-methylphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O2
    (5S,6R)-5-(3-methylphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-phenyl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H25N5O2
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-phenyl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-[4-(diethylamino)phenyl]-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H30N6O2
    (5S,6R)-5-[4-(diethylamino)phenyl]-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O5
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-methoxyphenyl)-2-[(3R)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O3
    (5R,6S)-5-(4-methoxyphenyl)-2-[(3R)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-[(3S)-3-methylpiperidin-1-yl]-5-naphthalen-1-yl-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H23N5O2
    (5R,6S)-2-[(3S)-3-methylpiperidin-1-yl]-5-naphthalen-1-yl-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(3-ethoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5R,6S)-5-(3-ethoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O3
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(3-ethoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5R,6R)-5-(3-ethoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O5
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-hydroxynaphthalen-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C30H27N5O3
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-hydroxynaphthalen-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O3
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-[(3R)-3-methylpiperidin-1-yl]-5-naphthalen-1-yl-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H23N5O2
    (5R,6S)-2-[(3R)-3-methylpiperidin-1-yl]-5-naphthalen-1-yl-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dichlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H23Cl2N5O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dichlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O5
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H25N5O3
    (5R,6S)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-5-(4-methylphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O2
    (5R,6R)-2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-5-(4-methylphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O5
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(4-bromophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H24BrN5O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(4-bromophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-hydroxy-3-methoxyphenyl)-2-[(3R)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6S)-5-(2-hydroxy-3-methoxyphenyl)-2-[(3R)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O3
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O3
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2-chlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H24ClN5O2
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2-chlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(1H-indol-3-yl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H22N6O2
    (5R,6S)-5-(1H-indol-3-yl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-[4-(3-methylbutoxy)phenyl]-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C25H31N5O3
    (5R,6S)-5-[4-(3-methylbutoxy)phenyl]-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O5
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O5
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-[(1R)-cyclohex-3-en-1-yl]-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H25N5O2
    (5S,6S)-5-[(1R)-cyclohex-3-en-1-yl]-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3-methylphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O2
    (5S,6S)-5-(3-methylphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-phenyl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H25N5O2
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-phenyl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-phenyl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H25N5O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-phenyl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-hydroxy-3-methoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6S)-5-(2-hydroxy-3-methoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(3-ethoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5S,6R)-5-(3-ethoxyphenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dichlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H23Cl2N5O2
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dichlorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2-chloro-6-fluorophenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H19ClFN5O2
    (5S,6S)-5-(2-chloro-6-fluorophenyl)-2-[(3S)-3-methylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-5-(4-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H27N5O3
    (5S,6R)-2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-5-(4-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O3
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2-ethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O3
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-chlorophenyl)-2-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H22ClN5O2
    (5R,6S)-5-(4-chlorophenyl)-2-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile