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    —— (5S,6S)-5-(2-hydroxynaphthalen-1-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H21N5O3
    (5S,6S)-5-(2-hydroxynaphthalen-1-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18ClN5O2
    (5S,6R)-5-(2-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(4-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18FN5O2
    (5R,6R)-5-(4-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O4
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C31H35N5O3
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H25N5O3
    (5S,6S)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6S)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18ClN5O2
    (5S,6S)-5-(3-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-4,7-dioxo-2-piperidin-1-yl-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H23N5O3
    (5R,6R)-4,7-dioxo-2-piperidin-1-yl-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2-fluoro-5-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H17FN6O4
    (5S,6S)-5-(2-fluoro-5-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O4
    (5R,6R)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18ClN5O2
    (5R,6S)-5-(4-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2,4-dichlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H19Cl2N5O2
    (5S,6S)-5-(2,4-dichlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2-chloro-6-fluorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H19ClFN5O2
    (5S,6S)-5-(2-chloro-6-fluorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(3,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5S,6R)-5-(3,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O4
    (5S,6S)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(4-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O2
    (5S,6R)-5-(4-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-chlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20ClN5O2
    (5R,6S)-5-(4-chlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-methylpiperidin-1-yl)-5-(4-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20N6O4
    (5S,6R)-2-(4-methylpiperidin-1-yl)-5-(4-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H27N5O5
    (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(furan-2-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C17H17N5O3
    (5R,6S)-5-(furan-2-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6R)-5-(2,5-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18ClN5O2
    (5R,6R)-5-(2-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-4,7-dioxo-2-piperidin-1-yl-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O5
    (5S,6S)-4,7-dioxo-2-piperidin-1-yl-5-(2,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18BrN5O2
    (5S,6S)-5-(3-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-4,7-dioxo-2-piperidin-1-yl-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5S,6S)-4,7-dioxo-2-piperidin-1-yl-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-4,7-dioxo-2-piperidin-1-yl-5-pyridin-2-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C18H18N6O2
    (5S,6R)-4,7-dioxo-2-piperidin-1-yl-5-pyridin-2-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O2
    (5S,6S)-5-(3-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6R)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-fluoro-5-nitrophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H19FN6O4
    (5R,6R)-5-(2-fluoro-5-nitrophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-methylpiperidin-1-yl)-5-[4-(2-methylpropyl)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H29N5O2
    (5R,6R)-2-(4-methylpiperidin-1-yl)-5-[4-(2-methylpropyl)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-4,7-dioxo-2-piperidin-1-yl-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H23N5O3
    (5R,6S)-4,7-dioxo-2-piperidin-1-yl-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5S,6S)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6R)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(3-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18ClN5O2
    (5R,6R)-5-(3-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-[4-(dimethylamino)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H26N6O2
    (5R,6S)-5-[4-(dimethylamino)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-4,7-dioxo-5-(3-phenoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C25H23N5O3
    (5S,6S)-4,7-dioxo-5-(3-phenoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-[(1R)-cyclohex-3-en-1-yl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H23N5O2
    (5S,6S)-5-[(1R)-cyclohex-3-en-1-yl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5R,6S)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(4-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18BrN5O2
    (5S,6S)-5-(4-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-[(E)-2-phenylethenyl]-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H23N5O2
    (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-[(E)-2-phenylethenyl]-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(3-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5S,6R)-5-(3-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-4,7-dioxo-2-piperidin-1-yl-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5R,6R)-4,7-dioxo-2-piperidin-1-yl-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O3
    (5R,6S)-5-(2-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5R,6R)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O4
    (5R,6S)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-methylpiperidin-1-yl)-5-[4-(2-methylpropyl)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H29N5O2
    (5S,6S)-2-(4-methylpiperidin-1-yl)-5-[4-(2-methylpropyl)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O3
    (5R,6S)-5-(4-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-chloro-6-fluorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H19ClFN5O2
    (5R,6S)-5-(2-chloro-6-fluorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(3,4-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O4
    (5R,6R)-5-(3,4-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile