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    —— (5R,6S)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5R,6S)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-[4-(diethylamino)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H28N6O2
    (5R,6R)-5-[4-(diethylamino)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— 5-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-2-pyrimidin-2-yl-1H-pyrazolo[4,3-c]pyridine-3,6-dione —— C19H16FN5O2
    5-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-2-pyrimidin-2-yl-1H-pyrazolo[4,3-c]pyridine-3,6-dione
    —— (5R,6R)-5-(3,5-difluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H17F2N5O2
    (5R,6R)-5-(3,5-difluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-ethylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O2
    (5R,6S)-5-(4-ethylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(3,5-difluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H17F2N5O2
    (5S,6R)-5-(3,5-difluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5S,6R)-5-(2-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— 5-[2-[(1R)-cyclohex-3-en-1-yl]ethyl]-4-methyl-2-pyrimidin-2-yl-1H-pyrazolo[4,3-c]pyridine-3,6-dione —— C19H21N5O2
    5-[2-[(1R)-cyclohex-3-en-1-yl]ethyl]-4-methyl-2-pyrimidin-2-yl-1H-pyrazolo[4,3-c]pyridine-3,6-dione
    —— 5-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-2-(3-methylphenyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione —— C22H20FN3O2
    5-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-2-(3-methylphenyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione
    —— 5-[2-[(1R)-cyclohex-3-en-1-yl]ethyl]-4-methyl-2-(2-methylphenyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione —— C22H25N3O2
    5-[2-[(1R)-cyclohex-3-en-1-yl]ethyl]-4-methyl-2-(2-methylphenyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione
    —— 5-[2-[(1S)-cyclohex-3-en-1-yl]ethyl]-4-methyl-2-(2-methylphenyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione —— C22H25N3O2
    5-[2-[(1S)-cyclohex-3-en-1-yl]ethyl]-4-methyl-2-(2-methylphenyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione
    —— (5S,6R)-5-(3-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O2
    (5S,6R)-5-(3-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— 5-[(1S)-1-(4-chlorophenyl)ethyl]-2,4-dimethyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione —— C16H16ClN3O2
    5-[(1S)-1-(4-chlorophenyl)ethyl]-2,4-dimethyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione
    —— 5-[(1R)-1-(4-chlorophenyl)ethyl]-2,4-dimethyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione —— C16H16ClN3O2
    5-[(1R)-1-(4-chlorophenyl)ethyl]-2,4-dimethyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione
    —— (5R,6R)-5-(2-fluoro-5-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H17FN6O4
    (5R,6R)-5-(2-fluoro-5-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18ClN5O2
    (5S,6S)-5-(2-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(3-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18N6O4
    (5R,6S)-5-(3-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(4-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18BrN5O2
    (5R,6R)-5-(4-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O4
    (5S,6R)-5-(2-hydroxy-3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18FN5O2
    (5R,6S)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5R,6R)-5-(2-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5R,6R)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-chlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20ClN5O2
    (5R,6S)-5-(2-chlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18FN5O2
    (5S,6S)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(3,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6S)-5-(3,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(3,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6R)-5-(3,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18N6O4
    (5S,6S)-5-(3-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5S,6S)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-hydroxynaphthalen-1-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H21N5O3
    (5R,6R)-5-(2-hydroxynaphthalen-1-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5S,6S)-5-(3-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5S,6S)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(3-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O2
    (5R,6S)-5-(3-methylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5S,6R)-5-(2,4-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-[(1R)-cyclohex-3-en-1-yl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H25N5O2
    (5R,6R)-5-[(1R)-cyclohex-3-en-1-yl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(4-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H24N6O4
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(4-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-propan-2-ylphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H27N5O2
    (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-propan-2-ylphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H25N5O3
    (5R,6S)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-4,7-dioxo-5-[(E)-2-phenylethenyl]-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H21N5O2
    (5R,6S)-4,7-dioxo-5-[(E)-2-phenylethenyl]-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(4-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18ClN5O2
    (5R,6R)-5-(4-chlorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18N6O4
    (5R,6S)-5-(4-nitrophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(3,5-difluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H17F2N5O2
    (5S,6S)-5-(3,5-difluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H29N5O3
    (5R,6S)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5S,6R)-5-(2,3-dimethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H25N5O3
    (5S,6R)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(4-chlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20ClN5O2
    (5S,6R)-5-(4-chlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O3
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-hydroxy-3-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O4
    (5R,6R)-5-(2-hydroxy-3-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-propan-2-ylphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H27N5O2
    (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-propan-2-ylphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H29N5O3
    (5S,6S)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-[4-(diethylamino)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H28N6O2
    (5S,6R)-5-[4-(diethylamino)phenyl]-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile