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    —— (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H27N5O5
    (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C31H35N5O3
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-[4-(3-methylbutoxy)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-pyridin-3-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C25H24N6O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-pyridin-3-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-naphthalen-1-yl-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C30H27N5O2
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-naphthalen-1-yl-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(4-ethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O3
    (5R,6S)-5-(4-ethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-3-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H20N6O2
    (5S,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-3-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-[4-(3-methylbutoxy)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C25H31N5O3
    (5S,6R)-5-[4-(3-methylbutoxy)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(3-methoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C27H27N5O3
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(3-methoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H29N5O3
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(2-prop-2-enoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H20N6O2
    (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(3-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H24N6O4
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(3-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2,4-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O4
    (5S,6R)-5-(2,4-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(4-ethylphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H29N5O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(4-ethylphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(1H-indol-3-yl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H22N6O2
    (5S,6S)-5-(1H-indol-3-yl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-methylpiperidin-1-yl)-5-(4-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20N6O4
    (5R,6S)-2-(4-methylpiperidin-1-yl)-5-(4-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-methylpiperidin-1-yl)-5-(4-methylsulfanylphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O2S
    (5R,6S)-2-(4-methylpiperidin-1-yl)-5-(4-methylsulfanylphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(furan-2-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C17H17N5O3
    (5S,6S)-5-(furan-2-yl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18FN5O2
    (5S,6R)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H20N6O2
    (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(2,3-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O4
    (5S,6S)-5-(2,3-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(3-phenoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H25N5O3
    (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(3-phenoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C23H27N5O3
    (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-propoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(3,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C29H31N5O5
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-(3,4,5-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-[4-(dimethylamino)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H26N6O2
    (5R,6R)-5-[4-(dimethylamino)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(4-ethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O3
    (5S,6S)-5-(4-ethoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-[(1R)-cyclohex-3-en-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H29N5O2
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-5-[(1R)-cyclohex-3-en-1-yl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H20N6O2
    (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-5-(4-ethylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O2
    (5S,6S)-5-(4-ethylphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O3
    (5S,6R)-5-(3-methoxyphenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C25H24N6O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-pyridin-4-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(1H-indol-3-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C28H26N6O2
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(1H-indol-3-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C27H27N5O3
    (5S,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-(4-phenylmethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(2,3-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O4
    (5S,6R)-5-(2,3-dimethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18FN5O2
    (5R,6R)-5-(2-fluorophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-pyridin-2-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C25H24N6O2
    (5R,6S)-2-(4-benzylpiperidin-1-yl)-4,7-dioxo-5-pyridin-2-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(4-bromophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20BrN5O2
    (5R,6R)-5-(4-bromophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-5-(2,4-dichlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H19Cl2N5O2
    (5R,6R)-5-(2,4-dichlorophenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(3-bromophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H24BrN5O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(3-bromophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-phenyl-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O2
    (5R,6R)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-phenyl-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(4-methoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C27H27N5O3
    (5S,6R)-2-(4-benzylpiperidin-1-yl)-5-(4-methoxyphenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-methylpiperidin-1-yl)-5-(3-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H20N6O4
    (5S,6S)-2-(4-methylpiperidin-1-yl)-5-(3-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(3-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C19H18BrN5O2
    (5S,6R)-5-(3-bromophenyl)-4,7-dioxo-2-piperidin-1-yl-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(2-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C22H25N5O3
    (5R,6S)-5-(2-ethoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-[4-(3-methylbutoxy)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C25H31N5O3
    (5R,6S)-5-[4-(3-methylbutoxy)phenyl]-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-2-(4-methylpiperidin-1-yl)-5-[4-(2-methylpropyl)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C24H29N5O2
    (5S,6R)-2-(4-methylpiperidin-1-yl)-5-[4-(2-methylpropyl)phenyl]-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-5-(3-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C21H23N5O3
    (5R,6S)-5-(3-methoxyphenyl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6R)-5-(furan-2-yl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C18H19N5O3
    (5S,6R)-5-(furan-2-yl)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-chloro-6-fluorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H23ClFN5O2
    (5R,6R)-2-(4-benzylpiperidin-1-yl)-5-(2-chloro-6-fluorophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2-chloro-5-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C26H23ClN6O4
    (5S,6S)-2-(4-benzylpiperidin-1-yl)-5-(2-chloro-5-nitrophenyl)-4,7-dioxo-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
    —— (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-phenyl-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile —— C20H21N5O2
    (5R,6S)-2-(4-methylpiperidin-1-yl)-4,7-dioxo-5-phenyl-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile