甘草芳香豆素 | 125709-31-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 中文名称: 甘草芳香豆素
• 英文名称: licoarylcoumarin
• 英文别名: 3-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-(2-methylbut-3-en-2-yl)chromen-2-one
• CAS: 125709-31-1
• 化学式: C₂₁H₂₀O₆
• 分子量: 368.386
• InChiKey: LCRIQVFKVCYUAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甘草芳香豆素 生成 Acetic acid 3-(2,4-diacetoxy-phenyl)-8-(1,1-dimethyl-allyl)-5-methoxy-2-oxo-2H-chromen-7-yl ester
  参考文献：
  名称：

  Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.

  摘要：

  使用液滴逆流色谱法和离心分离色谱法从Si-pei甘草（一种商业甘草；中国西北地区甘草属植物的根和匍匐茎）中分离出一种抗HIV（人类免疫缺陷病毒）的酚类成分甘草素（4）以及两种新的酚类成分甘草素（5）和甘草黄酮（6），并根据化学和光谱数据确定了其结构。还从甘草中分离出山奈酚3-O-甲醚（7）和甘草黄酮（8）。研究了十种甘草酚类化合物对黄嘌呤氧化酶的抑制作用。甘草黄酮B（1）、甘草黄酮（2）、8和甘草黄酮A（19）在浓度为1.3-5.6×10<-5>M时显示出50%的抑制作用。

  DOI：

  10.1248/cpb.37.3005

文献信息

• Compositions and methods for promoting weight loss, thermogenesis, appetite suppression, lean muscle mass, increasing metabolism and boosting energy levels, and use as a dietary supplement in mammals
  申请人：——

  公开号：US20040077556A1

  公开（公告）日：2004-04-22

  The invention is both a composition and a method for promoting weight loss in mammals, for promoting thermogenesis in mammals, for increasing metabolism and boosting energy levels in mammals, promoting appetite suppression in mammals, for promoting lean muscle mass in mammals and for a diet supplement. The primary mechanism of action for the invention is that it increases norepinephrine levels, which promotes a rise in metabolism, thus leading to more calories burned and more energy expended primarily through the burning or metabolism of adipose tissue (fat) through lipolysis, without the destruction or metabolism of muscle tissue. The present invention relates to a nutritional supplement composition, and the methods for the administration thereof, comprising of (1) an effective amount of epigallocatechin gallate (EGCG), the chemical name of which has been described as ((2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate), and (2) various other substances (singly or in any combination thereof), which either (a) inhibit cyclic adenosine monophosphate (cAMP) phosphodiesterase, (b) stimulate lipolysis, (c) stimulate thermogenesis (i.e., increase metabolism) (d) and/or increase norepinephrine levels, or (e) any combination thereof. In a preferred embodiment, the basic invention is a composition, and a method for the administration thereof, comprising effective amounts of epigallocatechin gallate, caffeine, and l-tyrosine.

  本发明既是一种组合物，也是一种方法，可用于促进哺乳动物减肥、促进哺乳动物产热、提高哺乳动物的新陈代谢和能量水平、促进哺乳动物食欲抑制、促进哺乳动物瘦肌肉质量，也是一种饮食补充剂。本发明的主要作用机理是提高去甲肾上腺素水平，促进新陈代谢，从而主要通过脂肪分解燃烧或代谢脂肪组织（脂肪）来消耗更多卡路里和更多能量，而不破坏或代谢肌肉组织。 本发明涉及一种营养补充剂组合物及其施用方法，该组合物包括（1）有效量的表没食子儿茶素没食子酸酯（EGCG），其化学名称已被描述为（(2R,3R)-2-(3,4,5-三羟基苯基)-3,4-二氢-1&lsqb；2H]-苯并吡喃-3,5,7-三醇 3-(3,4,5-三羟基苯甲酸酯)，以及 (2) 其他各种物质（单独使用或任意组合使用），这些物质(a) 可抑制环磷酸腺苷（cAMP）磷酸二酯酶，(b) 可刺激脂肪分解，(c) 可刺激产热（即 "产热"）。e.,(d) 和/或增加去甲肾上腺素水平，或 (e) 以上任何组合。 在一个优选的实施方案中，本发明是一种组合物及其施用方法，其中包含有效量的表没食子儿茶素没食子酸酯、咖啡因和 l-酪氨酸。
• COMPOSITIONS AND METHODS FOR PROMOTING WEIGHT LOSS, THERMOGENESIS, APPETITE SUPPRESSION, LEAN MUSCLE MASS, INCREASING METABOLISM AND BOOSTING ENERGY LEVELS, AND USE AS A DIETARY SUPPLEMENT IN MAMMALS
  申请人：RTC Research & Development, LLC.

  公开号：EP1578401A2

  公开（公告）日：2005-09-28
• EP1578401A4
  申请人：——

  公开号：EP1578401A4

  公开（公告）日：2009-03-25
• DEVELOPMENT OF HEALTH FOOD SUPPLEMENTS AND ANTIOXIDANTS FOR CONTROLLING HYPERURICEMIA AND OXIDATIVE STRESS
  申请人：Baylor College of Medicine

  公开号：EP3809871A2

  公开（公告）日：2021-04-28
• [EN] COMPOSITIONS AND METHODS FOR PROMOTING WEIGHT LOSS, THERMOGENESIS, APPETITE SUPPRESSION, LEAN MUSCLE MASS, INCREASING METABOLISM AND BOOSTING ENERGY LEVELS, AND USE AS A DIETARY SUPPLEMENT IN MAMMALS<br/>[FR] COMPOSITIONS ET METHODES POUR FAVORISER LA PERTE DE POIDS, LA THERMOGENESE, LA DIMINUTION DE LA FAIM, UNE MASSE MUSCULAIRE MAIGRE, AUGMENTER LE METABOLISME ET AMPLIFIER LES NIVEAUX ENERGETIQUES ET UTILISATION EN TANT QUE COMPLEMENT ALIMENTAIRE CHEZ DES MAMMIFERES
  申请人：RTC RES & DEV LLC

  公开号：WO2003090673A2

  公开（公告）日：2003-11-06

  The invention is both a composition and a method for promoting weight loss in mammals, for promoting thermogenesis in mammals, for increasing metabolism and boosting energy levels in mammals, promoting appetite suppression in mammals, for promoting lean muscle mass in mammals and for a diet supplement. The primary mechanism of action for the invention is that it increases norepinephrine levels, which promotes a rise in metabolism, thus leading to more calories burned and more energy expended primarily through the burning or metabolism of adipose tissue (fat) through lipolysis, without the destruction or metabolism of muscle tissue. The present invention relates to a nutritional supplement composition, and the methods for the administration thereof, comprising of (1) an effective amount of epigallocatechin gallate (EGCG), the chemical name of which has been described as ((2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate), and (2) various other substances (singly or in any combination thereof), which either (a) inhibit cyclic adenosine monophosphate (cAMP) phosphodiesterase, (b) stimulate lipolysis, (c) stimulate thermogenesis (i.e., increase metabolism) (d) and/or increase norepinephrine levels, or (e) any combination thereof. In a preferred embodiment, the basic invention is a composition, and a method for the administration thereof, comprising effective amounts of epigallocatechin gallate, caffeine, and l-tyrosine.