licopyranocoumarin | 117038-80-9

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡喃类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: licopyranocoumarin
• 英文别名: [125I]-Licopyranocoumarin；7-(2,4-dihydroxyphenyl)-2-(hydroxymethyl)-5-methoxy-2-methyl-3,4-dihydropyrano[3,2-g]chromen-8-one
• CAS: 117038-80-9
• 化学式: C₂₁H₂₀O₇
• 分子量: 384.386
• InChiKey: MOBCUWLJOZHPQL-UHFFFAOYSA-N

物化性质

• 沸点：
  675.3±55.0 °C(Predicted)
• 密度：
  1.397±0.06 g/cm3(Predicted)
• 物理描述：
  Solid
• 熔点：
  137°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  licopyranocoumarin 生成 Acetic acid 5-acetoxy-2-(8-acetoxymethyl-5-methoxy-8-methyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-3-yl)-phenyl ester
  参考文献：
  名称：

  HATANO, TSUTOMU;YASUHARA, TAEKO;MIYAMOTO, KANJI;OKUDA, TAKUO, CHEM. AND PHARM. BULL., 36,(1988) N 6, C. 2286-2288

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.
  作者：Tsutomu HATANO、Taeko YASUHARA、Toshiyuki FUKUDA、Tadataka NORO、Takuo OKUDA

  DOI：10.1248/cpb.37.3005

  日期：——

  An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data. Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice. The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licohalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3-5.6×10<-5>M.

  使用液滴逆流色谱法和离心分离色谱法从Si-pei甘草（一种商业甘草；中国西北地区甘草属植物的根和匍匐茎）中分离出一种抗HIV（人类免疫缺陷病毒）的酚类成分甘草素（4）以及两种新的酚类成分甘草素（5）和甘草黄酮（6），并根据化学和光谱数据确定了其结构。还从甘草中分离出山奈酚3-O-甲醚（7）和甘草黄酮（8）。研究了十种甘草酚类化合物对黄嘌呤氧化酶的抑制作用。甘草黄酮B（1）、甘草黄酮（2）、8和甘草黄酮A（19）在浓度为1.3-5.6×10<-5>M时显示出50%的抑制作用。
• Anti-HIV composition and method for treating HIV infection with an anti-HIV agent containing crude drug
  申请人：Showa Shell Sekiyu Kabushiki Kaisha

  公开号：EP0753305A1

  公开（公告）日：1997-01-15

  In order to resolve problems that occur when single administration of a dideoxynucleotide such as AZT, ddI or the like is carried out, this invention provides a number of anti-HIV agents which are effective in treating the onset of HIV and have fewer side effects. Particularly, it provides an anti-HIV composition which includes an active agent in a therapeutically effective amount and a pharmaceutically acceptable carrier, wherein the active agent is at least one crude drug selected from the group consisting of Alpinia officinarum Hance, Geum japonicum Thunb., Paeonia suffruticosa Andrews, Phellodendron amurence Ruprecht, Punica granatum L., Rhus javanica L., Syzygium aromaticum (L.) Merr. et Perry, Terminalia arjuna Wight et Arn., and Terminalia chebula Retzus. It also provides a method for treating HIV infection, including orally administering to a subject in need thereof a therapeutically effective amount of an anti-HIV agent containing as an active agent at least one crude drug is selected from the group consisting of Alpinia officinarum Hance, Geum japonicum Thunb., Paeonia suffruticosa Andrews, Phellodendron amurence Ruprecht, Punica granatum L., Rhus javanica L., Syzygium aromaticum (L.) Merr. et Perry, Terminalia arjuna Wight et Arn., and Terminalia chebula Retzus.

  为了解决单次服用双脱氧核苷酸（如 AZT、ddI 或类似物）时出现的问题，本发明提供了一些抗艾滋病毒制剂，这些制剂能有效治疗艾滋病毒的发病，而且副作用较小。特别是，本发明提供了一种抗 HIV 组合物，它包括治疗有效量的活性剂和药学上可接受的载体，其中活性剂是至少一种选自以下组别的粗制药物：Alpinia officinarum Hance、Geum japonicum Thunb、Paeonia suffruticosa Andrews、Phellodendron amurence Ruprecht、Punica granatum L.、Rhus javanica L.、Syzygium aromaticum (L.) Merr. et Perry、Terminalia arjuna Wight et Arn.和 Terminalia chebula Retzus。它还提供了一种治疗 HIV 感染的方法，包括向有需要的受试者口服治疗有效量的抗 HIV 制剂，该制剂含有至少一种粗制药物，这些粗制药物选自以下组：Alpinia officinarum Hance、Geum japonicum Thunb、Paeonia suffruticosa Andrews、Phellodendron amurence Ruprecht、Punica granatum L.、Rhus javanica L.、Syzygium aromaticum (L.) Merr. et Perry、Terminalia arjuna Wight et Arn.和 Terminalia chebula Retzus。
• Anti-human immunodeficiency virus phenolics from licorice.
  作者：Tsutomu Hatano、Taeko Yasuhara、Kanji Miyamoto、Takuo Okuda

  DOI：10.1248/cpb.36.2286

  日期：——

  Five phenolics isolated from licorice inhibited the cytopathic activity of a human immmunodeficiency virus. One of these a coumarin derivative named licopyranocoumarin, isolated from Xi-bei licorice, had structure 5, based on the chemical and spectroscopic evidence.
• Use of crude plant extract for the preparation of a medicament for treating HIV infection
  申请人：Showa Shell Sekiyu Kabushiki Kaisha

  公开号：EP0753305B1

  公开（公告）日：2000-08-30