(1-壬基)三苯基溴化磷 | 60902-45-6

• 物质功能分类: 有机原料
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (1-壬基)三苯基溴化磷
• 中文别名: 壬基三苯膦酰氯
• 英文名称: nonyltriphenylphosphonium bromide
• 英文别名: (1-nonyl)triphenylphosphonium bromide；(n-nonyl)triphenylphosphonium bromide；nonyl(triphenyl)phosphanium;bromide
• CAS: 60902-45-6
• 化学式: Br*C₂₇H₃₄P
• 分子量: 469.445
• InChiKey: NJXRQGKTLWXMID-UHFFFAOYSA-M

物化性质

• 熔点：
  65-68 °C
• 稳定性/保质期：
  避免接触氧化物和水。

计算性质

• 辛醇/水分配系数(LogP)：
  3.74
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 危险类别码：
  R36/37/38
• 海关编码：
  2931900090
• 安全说明：
  S26,S36

SDS

Name:	n-Nonyltriphenylphosphonium bromide Material Safety Data Sheet
Synonym:
CAS:	60902-45-6

Section 1 - Chemical Product MSDS Name:n-Nonyltriphenylphosphonium bromide Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
60902-45-6	n-Nonyltriphenylphosphonium bromide		262-521-1

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 60902-45-6: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 63 - 65 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C27H34BrP
Molecular Weight: 469.44

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of phosphorus, carbon dioxide, hydrogen bromide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 60902-45-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
n-Nonyltriphenylphosphonium bromide - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 60902-45-6: No information available.
Canada
CAS# 60902-45-6 is listed on Canada's NDSL List.
CAS# 60902-45-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 60902-45-6 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (1-壬基)三苯基溴化磷 在 palladium on activated charcoal 甲醇 、 正丁基锂 、 草酰氯 、 氢气 、 magnesium 、 二甲基亚砜 、 三乙胺 作用下， 以 乙酸乙酯 、 甲苯 为溶剂， -70.0~25.0 ℃ 、101.33 kPa 条件下， 反应 14.5h， 生成 methyl (5S)-5-hydroxyhexadecanoate
  参考文献：
  名称：

  Kang, Suk-Ku; Kim, Sung-Gyu; Park, Dong-Chul, Journal of the Chemical Society. Perkin transactions I, 1993, # 1, p. 9 - 10

  摘要：

  DOI：
• 作为产物：
  描述：

  1-溴壬烷 、 三苯基膦 反应 2.5h， 生成 (1-壬基)三苯基溴化磷
  参考文献：
  名称：

  天然存在的非丙酮产乙酸原的拟态研究：非THF类似物导致对人类肿瘤细胞的显着选择性细胞毒性。

  摘要：

  开发了一类天然存在的非丙酮产乙酸原素的结构简化的类似物，其中一些非THF类似物对肿瘤细胞系显示出显着的细胞毒性，并且在人肿瘤细胞和正常细胞之间具有良好的选择性。由于去除了天然模板上带有THF环的手性中心，合成路线大大缩短。这种简化还提供了通过组合策略对这些模拟物进行并行综合的途径。Chiron方法通过容易获得的手性结构单元6a和/或6b（由L-抗坏血酸或D-甘露醇依次制得，而丁烯内酯中的一个由手性构成）引入了其余的立体异构中心（位于醚键的α位）。片段取自L-乳酸盐。所有四个非对映异构体非THF类似物2a-2d对HCT-8细胞系均表现出显着活性，并且在针对HT-29细胞系进行测试时发现了更好的分化。还发现，丁烯内酯和乙二醇亚基均在针对肿瘤细胞系的细胞毒性中起重要作用，而丁烯内酯部分上的10-取代的羟基和甲基的绝对构型对其活性不太重要。

  DOI：

  10.1002/chem.200390021

文献信息

• Total synthesis of leopolic acid A, a natural 2,3-pyrrolidinedione with antimicrobial activity
  作者：Atul A Dhavan、Rahul D Kaduskar、Loana Musso、Leonardo Scaglioni、Piera Anna Martino、Sabrina Dallavalle

  DOI：10.3762/bjoc.12.159

  日期：——

  The first total synthesis of leopolic acid A, a fungal metabolite with a rare 2,3-pyrrolidinedione nucleus linked to an ureido dipeptide, was designed and carried out. Crucial steps for the strategy include a Dieckmann cyclization to obtain the 2,3-pyrrolidinedione ring and a Wittig olefination to install the polymethylene chain. An oxazolidinone-containing leopolic acid A analogue was also synthesized

  设计并进行了Leopolic acid A（一种具有稀有的2,3-吡咯烷二酮核与脲基二肽连接的真菌代谢物）的首次全合成。该策略的关键步骤包括Dieckmann环化以获得2,3-吡咯烷二酮环和Wittig烯化以安装聚亚甲基链。还合成了含恶唑烷酮的leopolic acid A类似物。两种化合物显示的抗菌活性表明它们可以被认为是未来开发的有希望的候选者。
• Catalytic asymmetric epoxidation
  申请人：——

  公开号：US06348608B1

  公开（公告）日：2002-02-19

  A compound and method for producing an enantiomerically enriched epoxide from an olefin using a chiral ketone and an oxidizing agent is disclosed.

  一种化合物及其生产方法被披露，该方法使用手性酮和氧化剂从烯烃生产具有对映体富集的环氧乙烷。
• Total Synthesis of (+)-Batzelladine A and (−)-Batzelladine D via [4 + 2]-Annulation of Vinyl Carbodiimides with <i>N</i>-Alkyl Imines
  作者：Michael A. Arnold、Kenneth A. Day、Sergio G. Durón、David Y. Gin

  DOI：10.1021/ja063860+

  日期：2006.10.1

  this strategy, together with additional key steps such as long-range directed hydrogenation and diastereoselective intramolecular iodo-amination, led to highly convergent total syntheses of (-)-batzelladine D and (+)-batzelladine A with excellent stereocontrol.

  已经开发出乙烯基碳二亚胺与手性 N-烷基亚胺的非对映选择性 [4 + 2]-环化，以获取 batzelladine 生物碱的立体化学丰富的多环胍核。该策略的应用，连同其他关键步骤，如远程定向氢化和非对映选择性分子内碘胺化，导致 (-)-batzelladine D 和 (+)-batzelladine A 的高度收敛全合成具有出色的立体控制。
• Simple salts of abundant metals (Fe, Bi, and Ti) supported on montmorillonite as efficient and recyclable catalysts for regioselective intramolecular and intermolecular hydroalkoxylation reactions of double bonds and tandem processes
  作者：Irene Notar Francesco、Bastien Cacciuttolo、Oana Pascu、Cyril Aymonier、Mathieu Pucheault、Sylvain Antoniotti

  DOI：10.1039/c5ra25176a

  日期：——

  conditions has been studied using two types of solid catalysts, namely montmorillonite (MMT) doped with metal cations and metal nanoparticles supported on oxides. In the case of intramolecular reactions, 38–99% yields of cyclic ethers have been obtained using Fe-MMT and Bi-MMT both in CH3NO2 and dimethyl carbonate (DMC) compared with other supported metal salts or metal nanoparticles. In the case of more challenging

  已经使用两种类型的固体催化剂，即掺杂有金属阳离子的蒙脱石（MMT）和负载在氧化物上的金属纳米颗粒，研究了烯烃的催化加氢烷氧基化反应从均相转化为非均相条件的过程。在分子内反应的情况下，在CH 3 NO 2中使用Fe-MMT和Bi-MMT均可获得38-99％的环状醚收率碳酸二甲酯（DMC）与其他负载型金属盐或金属纳米粒子相比。在更具挑战性的分子间反应的情况下，使用金属掺杂的MMT（例如Fe-，Bi-和Ti-MMT）也可以获得高达72％的转化率和高达54％的产率。在本文中，我们详细介绍了被识别为真正异质催化过程的底物范围和限制，适用于两类反应和串联过程，它们在流动中的移位以及有关活性物质的一些机理见解。作为一般趋势，观察到三取代的双键在分子内和分子间反应中均能获得最佳结果。在Fe-MMT和Bi-MMT的情况下，均相催化剂成功转移到非均相催化剂上，在Bi-MMT的情况下，甚至可以提高催化活性。
• ピリジン化合物を用いる有害生物防除方法
  申请人：住友化学株式会社

  公开号：JP2019131611A

  公开（公告）日：2019-08-08

  【課題】有害生物の防除方法を提供すること。【解決手段】式（Ｉ）［式中、Ｒ1及びＲ2は、同一又は相異なり、Ｃ１−Ｃ１５鎖式炭化水素基等を表し、Ｒ3は、（Ｃ１−Ｃ３アルコキシ）Ｃ１−Ｃ３アルキル基等を表し、Ｒ4は、Ｃ１−Ｃ２アルキル基等を表し、Ｒ5は、Ｃ１−Ｃ４鎖式炭化水素基等を表し、Ｌ1は、単結合等を表し、Ｌ2は、単結合等を表し、ｎは、０又は１を表す。］で示される化合物は有害生物を防除することができる。【選択図】なし

  【课题】提供有害生物防除方法。【解决手段】式（Ｉ）（其中，R1和R2相同或不同，表示C1-C15链式烷基等；R3表示（C1-C3环氧）C1-C3烷基等；R4表示C1-C2烷基等；R5表示C1-C4链式烷基等；L1表示单键等；L2表示单键等；n表示0或1。）所示的化合物能够防除有害生物。【选择图】无