二十四烷二酸 | 2450-31-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 二十四烷二酸
• 英文名称: 1,24-tetracosanedi acid
• 英文别名: Tetracosandisaeure；tetracosanedioic acid；Docosan-dicarbonsaeure-(ω,ω')；Dokosan-1,22-dicarbonsaeure
• CAS: 2450-31-9
• 化学式: C₂₄H₄₆O₄
• 分子量: 398.627
• InChiKey: QXGVRGZJILVMDF-UHFFFAOYSA-N

物化性质

• 熔点：
  126.9-127.1 °C
• 沸点：
  549.4±23.0 °C(Predicted)
• 密度：
  0.962±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO（轻微、加热、超声处理）、甲醇（轻微、加热、超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  28
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2917190090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

SDS

Name:	Tetracosanedioic acid 99%(gc) Material Safety Data Sheet
Synonym:
CAS:	2450-31-9

Section 1 - Chemical Product MSDS Name:Tetracosanedioic acid 99%(gc) Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
2450-31-9	Tetracosanedioic acid, 99%(gc)	99	unlisted

Hazard Symbols: Not available.
Risk Phrases:

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Appearance: off-white.
Not available.
Target Organs: None.
Potential Health Effects
The toxicological properties of this material have not been investigated. Use appropriate procedures to prevent opportunities for direct contact with the skin or eyes and to prevent inhalation.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits +--------------------+-------------------+-------------------+-----------------+ | Chemical Name | ACGIH | NIOSH |OSHA - Final PELs| |--------------------|-------------------|-------------------|-----------------| | Tetracosanedioic ac|none listed |none listed |none listed | | id, 99%(gc) | | | | +--------------------+-------------------+-------------------+-----------------+ OSHA Vacated PELs: Tetracosanedioic acid, 99%(gc): No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment Eyes: Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Not available.
Appearance: off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 270 deg C
Freezing/Melting Point: 124.00 - 127.00 deg C
Autoignition Temperature: Not available.
Flash Point: > 110 deg C (> 230.00 deg F)
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.
Decomposition Temperature:
Solubility:
Specific Gravity/Density:
Molecular Formula: C24H46O4
Molecular Weight: 398.63

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Not available.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 2450-31-9 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Tetracosanedioic acid, 99%(gc) - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Chemical waste generators must determine whether a discarded chemical is classif as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Part Additionally, waste generators must consult state and local hazardous waste regu ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

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Section 14 - TRANSPORT INFORMATION

CDG/CPL
Not classified as hazardous for supply.
Canadian TDG
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 2450-31-9: No information available.
United Kingdom Occupational Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
WHMIS: Not available.
CAS# 2450-31-9 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 2450-31-9 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  二十四烷二酸 在 lithium aluminium tetrahydride 、 硫酸 、 氢溴酸 作用下， 反应 14.0h， 生成 1,24-二溴二十四烷
  参考文献：
  名称：

  Schill, Gottfried; Beckmann, Wolfgang; Vetter, Walter, Chemische Berichte, 1980, vol. 113, # 3, p. 941 - 954

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 24-acetoxytetracosanoate 在 chromium(VI) oxide 、 lithium aluminium tetrahydride 、 乙醚 、 溶剂黄146 作用下， 生成 二十四烷二酸
  参考文献：
  名称：

  Murray; Schoenfeld, Australian Journal of Chemistry, 1955, vol. 8, p. 437,439

  摘要：

  DOI：

文献信息

• CURING AGENTS FOR EPOXY RESINS
  申请人：Dershem Stephen M

  公开号：US20130012620A1

  公开（公告）日：2013-01-10

  The present invention relates to curatives for epoxy resins, and compositions (e.g. adhesives) containing such resins cured using the same methods of preparation and uses therefor. More specifically, the present invention relates to hybrid curatives for epoxy resins comprising both aromatic amine, phenol and/or phenyl ester moieties. A further aspect of the current invention relates to new imidazole catalysts that possess a combination of excellent cure latency as well as low cure temperature onset.

  本发明涉及环氧树脂的硬化剂，以及含有经相同制备方法固化的这种树脂的组合物（例如胶粘剂）及其用途。更具体地，本发明涉及用于环氧树脂的混合硬化剂，包括芳香胺、酚和/或苯酯基团。本发明的另一个方面涉及具有优异固化潜伏期和低固化温度起始点的新咪唑催化剂。
• Colorant compounds
  申请人：Banning H. Jeffrey

  公开号：US20060020141A1

  公开（公告）日：2006-01-26

  Compounds of the formula wherein M is either (1) a metal ion having a positive charge of +y wherein y is an integer which is at least 2, said metal ion being capable of forming a compound with at least two chromogen moieties, or (2) a metal-containing moiety capable of forming a compound with at least two chromogen moieties, z is an integer representing the number of chromogen moieties associated with the metal and is at least 2, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , a, b, c, d, Y, and z are as defined herein, Q − is a COO − group or a SO 3 — group, A is an organic anion, and CA is either a hydrogen atom or a cation associated with all but one of the Q − groups.

  式中的化合物，其中M是一个带有正电荷+y的金属离子，其中y是至少为2的整数，该金属离子能够与至少两个色团基团形成化合物，或者M是一个含金属基团的基团，能够与至少两个色团基团形成化合物，z是表示与金属相关的色团基团数量的整数，至少为2，R1、R2、R3、R4、R5、R6、R7、a、b、c、d、Y和z的定义如上所述，Q-是一个COO-基团或SO3-基团，A是一个有机阴离子，CA是一个氢原子或与除一个Q-基团之外的所有Q-基团相关联的阳离子。
• [EN] NOVEL PEPTIDE HORMONE ANALOGUES<br/>[FR] NOUVEAUX ANALOGUES D'HORMONE PEPTIDIQUE
  申请人：IP2IPO INNOVATIONS LTD

  公开号：WO2020249966A1

  公开（公告）日：2020-12-17

  The invention provides novel compounds which are peptide hormone analogues, and which are useful in treating disorders such as diabetes and obesity. The compounds of the general sequence recited in the specification possess a tailored profile with regards to potency properties at the glucagon and GLP-1 receptors. With regard to in vivo properties, administration of example peptides of the invention have been shown, in animal models, to result in increased weight loss. Preferred compounds achieve this without reducing food intake significantly..

  这项发明提供了一种新型的化合物，这些化合物是肽激素类似物，可用于治疗糖尿病和肥胖等疾病。根据说明书所述的一般序列的化合物具有针对胰高血糖素和GLP-1受体的效能特性。就体内特性而言，实施该发明的示例肽的给药在动物模型中已被证明会导致体重减轻。优选的化合物可以在不显著减少食物摄入的情况下实现这一点。
• Structural Analysis and Inclusion Mechanism of Native and Permethylated α-Cyclodextrin-Based Rotaxanes Containing Alkylene Axles
  作者：Yosuke Akae、Yasuhito Koyama、Hiromitsu Sogawa、Yoshihiro Hayashi、Susumu Kawauchi、Shigeki Kuwata、Toshikazu Takata

  DOI：10.1002/chem.201504882

  日期：2016.4.4

  The number of PMeCDs on the pseudorotaxane is flexible and mainly depends on the axle length. Peracetylated α‐CD (PAcCD)‐based rotaxanes are synthesized through O‐acetylation of the α‐CD‐based rotaxanes without any decomposition of the rotaxanated structures. The structures of PMeCD‐based [3]‐ and [4]rotaxanes, and the molecular dynamics calculations on [3]pseudorotaxanes, indicate that the tail face

  天然α-环糊精（α-CD）和全甲基化α-CD（PMeCD）的轮烷具有各种亚烷基短链作为轴，可以通过尿素封端法合成。天然α-CD倾向于形成[3]-或[5]假轮烷，而不是[2]-或[4]假轮烷，这表明偶联的CD充当单个片段。轴长为C18和C24的假轮烷的封端反应不会发生，因为轴末端被密集堆叠的CD覆盖。假轮烷上的PMeCD的数量是灵活的，并且主要取决于轴长。基于过乙酰化的α-CD（PAcCD）的轮烷是通过基于α-CD的轮烷的O-乙酰化而合成的，而轮烷的结构没有任何分解。基于PMeCD的[3]和[4]轮烷的结构，以及[3]假轮烷的分子动力学计算，表示PMeCD的尾面有规律地指向轮轴总站。根据获得的结果，可以得出结论，含有短亚烷基链的轮烷中CD的方向和数量取决于1）CD之间的相互作用，2）亚烷基轴的长度以及3）烷基之间的相互作用。 CD的轴端和尾端。
• Über einige höhere normale α,ω-Dicarbonsäuren
  作者：Hs. H. Günthard、S. D. Heinemann、V. Prelog

  DOI：10.1002/hlca.19530360528

  日期：——

  Ausgehend von Δ10,11-Undecensäure-methylester wurde ein Verfahren zur Herstellung von Eicosandisäure-(1,20) (C20), Tetracosandisäure-(1,24) (C24) und Hexacosandisäure-(1,26) (C26) ausgearbeitet.

  从Δ起始10,11 -undecenoic酸甲酯，为二十烷二酸（1.20）的制备方法（C 20），四烷酸（1.24）（C 24）和hexacosanedioic酸（1.26）（C 26）计算出。