叔丁氧羰基-3,3'-亚氨基二丙胺 | 82409-04-9

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 叔丁氧羰基-3,3'-亚氨基二丙胺
• 英文名称: N1-Boc-3,3'-iminodipropylamine
• 英文别名: tert-butyl N-{3-[(3-aminopropyl)amino]propyl}carbamate；N¹-(tert-butoxycarbonyl)norspermidine；t-butyl N-[3-(3-aminopropylamino)propyl] carbamate；Tert-butyl N-[3-(3-aminopropylamino)propyl]carbamate
• CAS: 82409-04-9
• 化学式: C₁₁H₂₅N₃O₂
• 分子量: 231.338
• InChiKey: DZFPOUXCPWBUDA-UHFFFAOYSA-N

物化性质

• 密度：
  1.001 g/mL at 20 °C(lit.)
• 闪点：
  125 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R34
• 危险品运输编号：
  UN 2734 8/PG 2

反应信息

• 作为反应物：
  描述：

  叔丁氧羰基-3,3'-亚氨基二丙胺 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 141.5h， 生成 tert-butyl (3-((N-(3-((N-(3-(6-amino-9H-purin-9-yl)propyl)-2-nitrophenyl)sulfonamido)propyl)-2-nitrophenyl)sulfonamido)propyl)carbamate
  参考文献：
  名称：

  Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site

  摘要：

  DNA is continuously damaged by endogenous and exogenous factors such as oxidative stress or DNA alkylating agents. These damaged nucleobases are removed by DNA N-glycosylase and form apurinic/apyrimidinic sites (AP sites) as intermediates in the base excision repair (BER) pathway. AP sites are also representative DNA damages formed by spontaneous hydrolysis. The AP sites block DNA polymerase and a mismatch nucleobase is inserted opposite the AP sites by polymerization to cause acute toxicities and mutations. Thus, AP site specific compounds have attracted much attention for therapeutic and diagnostic purposes. In this study, we have developed nucleobase-polyamine conjugates as the AP site binding ligand by expecting that the nucleobase part would play a role in the specific recognition of the nucleobase opposite the AP site by the Watson-Crick base pair formation and that the polyamine part should contribute to the access of the ligand to the AP site by a non-specific interaction to the DNA phosphate backbone. The nucleobase conjugated with 3,3'-diaminodipropylamine (A-ligand, G-ligand, C-ligand, T-ligand and U-ligand) showed a specific stabilization of the duplex containing the AP site depending on the complementary combination with the nucleobase opposite the AP site; that is A-ligand to T, G-ligand to C, C-ligand to G, T- and U-ligand to A. The thermodynamic binding parameters clearly indicated that the specific stabilization is due to specific binding of the ligands to the complementary AP site. These results have suggested that the complementary base pairs of the Watson-Crick type are formed at the AP site. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.04.009
• 作为产物：
  描述：

  3,3'-二氨基二丙基胺 在 sodium hydroxide 作用下， 以 乙醚 、 二甲基亚砜 为溶剂， 反应 2.0h， 生成 叔丁氧羰基-3,3'-亚氨基二丙胺
  参考文献：
  名称：

  脂肪族二，三和四胺的9-ac啶基和2-甲氧基-6-氯-9-rid啶基衍生物。化学，细胞抑制活性和血吸虫活性。

  摘要：

  1,6-己二胺，1,8-辛二胺，双（3-氨基丙基）胺，N，N'-双（3-氨基丙基）哌嗪和N-乙基-1,6-己二胺的9-ac啶基衍生物以高收率制备它们的盐酸盐形式的草甘膦，并将其转化成潜在的插入双异核苷的杂双DNA。通过将上述胺与9-氯ac啶一起加热来制备相应的潜在的均双bis DNA插入试剂。检查了idine啶的化学稳定性。已经确定了它们在体外对Cloudman黑色素瘤细胞的细胞抑制活性。对于三胺和四胺的cr啶衍生物观察到最强的细胞抑制活性。发现所选的a啶和二cr啶衍生物在小鼠中对曼氏血吸虫的血吸虫杀伤作用微不足道。S.

  DOI：

  10.1021/jm00364a028

文献信息

• 脂质化合物及其组合物
  申请人：广州市锐博生物科技有限公司

  公开号：CN113185421B

  公开（公告）日：2022-01-25

  本发明涉及一种脂质化合物及其组合物，包含其的脂质纳米颗粒，及其制备方法和在药物递送中的用途。
• HEPARAN SULFATE/HEPARIN MIMETICS WITH ANTI-CHEMOKINE AND ANTI-INFLAMMATORY ACTIVITY
  申请人：California Institute of Technology

  公开号：US20150038455A1

  公开（公告）日：2015-02-05

  The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.

  本公开提供了一系列合成糖聚合物的方法和组合物。该公开还涉及一种适用于执行创新方法的试剂盒。
• Total synthesis of polyamine amide spider toxin argiotoxin-636 by a practical reductive alkylation strategy
  作者：Ian S. Blagbrough、Eduardo Moya

  DOI：10.1016/0040-4039(95)01994-s

  日期：1995.12

  Reductive alkylation is a practical strategy for a total synthesis of spider toxin argiotoxin 636, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. Central to this synthesis are a Swern oxidation and a reductive alkylation.

  还原性烷基化是蜘蛛毒素argiotoxin 636（一种多胺酰胺，它是一种选择性的谷氨酸受体拮抗剂）的全合成的实用策略，可能具有神经保护剂的潜力。该合成的关键是Swern氧化和还原性烷基化。
• TAILORED GLYCOPOLYMERS AS ANTICOAGULANT HEPARIN MIMETICS
  申请人：California Institute of Technology

  公开号：US20150038436A1

  公开（公告）日：2015-02-05

  The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.

  本公开提供了一系列合成糖聚合物的方法和组合物。该公开还涉及一种适用于实施创新方法的试剂盒。
• 9-Acridinyl and 2-methoxy-6-chloro-9-acridinyl derivatives of aliphatic di-, tri-, and tetraamines. Chemistry, cytostatic activity, and schistosomicidal activity
  作者：John B. Hansen、Eyvind Langvad、Flemming Frandsen、Ole Buchardt

  DOI：10.1021/jm00364a028

  日期：1983.10

  9-acridinyl derivatives of 1,6-hexanediamine, 1,8-octanediamine, bis(3-aminopropyl)amine, N,N'-bis(3-amino-propyl)piperazine, and N-ethyl-1,6-hexanediamine in the form of their hydrochlorides were prepared in high yields and converted into potential hetero bis DNA intercalating diacridines. The corresponding potential homo bis DNA intercalating reagents were prepared by heating the above amines with

  1,6-己二胺，1,8-辛二胺，双（3-氨基丙基）胺，N，N'-双（3-氨基丙基）哌嗪和N-乙基-1,6-己二胺的9-ac啶基衍生物以高收率制备它们的盐酸盐形式的草甘膦，并将其转化成潜在的插入双异核苷的杂双DNA。通过将上述胺与9-氯ac啶一起加热来制备相应的潜在的均双bis DNA插入试剂。检查了idine啶的化学稳定性。已经确定了它们在体外对Cloudman黑色素瘤细胞的细胞抑制活性。对于三胺和四胺的cr啶衍生物观察到最强的细胞抑制活性。发现所选的a啶和二cr啶衍生物在小鼠中对曼氏血吸虫的血吸虫杀伤作用微不足道。S.