(1R,2S,5R)-2-isopropyl-5-methylcyclohex-1-yl hydroxyacetate | 117356-20-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2S,5R)-2-isopropyl-5-methylcyclohex-1-yl hydroxyacetate
• 英文别名: (-)-menthyl hydroxyacetate；glycolic acid menthyl ester；Glykolsaeure-menthylester；5-Methyl-2-(propan-2-yl)cyclohexyl 2-hydroxyacetate；(5-methyl-2-propan-2-ylcyclohexyl) 2-hydroxyacetate
• CAS: 117356-20-4
• 化学式: C₁₂H₂₂O₃
• mdl: MFCD08443445
• 分子量: 214.305
• InChiKey: FMATXKUIGQODAH-UHFFFAOYSA-N

物化性质

• 沸点：
  292.4±13.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.916
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 、 (1R,2S,5R)-2-isopropyl-5-methylcyclohex-1-yl hydroxyacetate 、 叔丁基二甲基氯硅烷 、 (-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate 、 (+)-(1S,2R)-2-Phenyl-1-cyclohexyl hydroxyacetate 、 三异丙基氯硅烷 以respectively, in 90-95% yields的产率得到(-)-trans-2-phenylcyclohexyl <(triisopropylsilyl)oxy>acetate
  参考文献：
  名称：

  Process for the production of chiral hydroxy-.beta.-lactams and

  摘要：

  羟基乙酸衍生物与带有氧保护基和手性辅助基团的亚胺反应，产生手性β-内酰胺。手性β-内酰胺水解后产生手性氨基酸类似物。

  公开号：

  US05294737A1
• 作为产物：
  描述：

  1,4-二氧杂环-2,5-己二酮 、 L-薄荷醇 生成 (1R,2S,5R)-2-isopropyl-5-methylcyclohex-1-yl hydroxyacetate
  参考文献：
  名称：

  DE136411

  摘要：

  公开号：

文献信息

• Domino Processes as a Tool for Recovering Substandard Reactions. Synthesis and Use of Nitroacetic Acid Esters and Amides
  作者：Noemi Scardovi、Andrea Casalini、Francesca Peri、Paolo Righi

  DOI：10.1021/ol0255357

  日期：2002.3.1

  [reaction: see text] Elusive nitroacetic acid esters and amides were obtained through a halogen exchange reaction of the corresponding bromoacetic acid derivatives with polymer-supported nitrite anion. The process is flawed by a side product catalyzed degradation of the products. Domino processes turned out to be a powerful tool for overcoming such drawbacks, converting a substandard reaction into

  [反应：见正文]通过相应的溴乙酸衍生物与聚合物负载的亚硝酸根阴离子的卤素交换反应，获得了难以捉摸的硝基乙酸酯和酰胺。该方法的缺点是副产物催化了产物的降解。事实证明，多米诺工艺是克服此类缺陷的有力工具，可以将次标准反应转化为有效的多组分4-羟基-4,5-二氢异恶唑的制备方法。
• TRICYCLIC CYTOPROTECTIVE COMPOUNDS
  申请人：Wulfert Ernst

  公开号：US20090259043A1

  公开（公告）日：2009-10-15

  Compounds of formula (I): [in which: X is a group of formula >CR 1 R 2 or >SO 2 ; Y is a group of formula >NH or >CR 1 R 2 ; Z is a group of formula >C═O or >CH 2 or a direct bond; R 1 is hydrogen and R 2 is hydrogen, carboxy or hydroxy; or R 1 and R 2 together represent an oxo group, a methylenedioxy group or a hydroxyimino group; R 3 is hydrogen or lower alkyl; R 4 represents two hydrogen atoms, or an oxo or hydroxyimino group; R 5 is hydrogen, lower alkyl or halogen; R 6 is hydrogen, lower alkoxy or carboxy; R 7 and R 8 are each hydrogen, lower alkyl or halogen; and pharmaceutically acceptable salts and esters thereof can be used for the treatment or prophylaxis of acute or chronic neurodegenerative diseases or conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Chorea, Multiple Sclerosis or the sequelae to acute ischaemic events such as heart attack, stroke or head injury and for protection against ischaemic damage to tissues of peripheral organs.

  式(I)的化合物：[其中：X是公式>CR1R2或>SO2的基团；Y是公式>NH或>CR1R2的基团；Z是公式>C═O或>CH2或直接键的基团；R1是氢原子，R2是氢原子，羧基或羟基；或R1和R2一起代表氧代基、甲亚基二氧基基团或羟基亚胺基团；R3是氢原子或较低的烷基；R4代表两个氢原子或氧代基或羟基亚胺基团；R5是氢原子、较低的烷基或卤素；R6是氢原子、较低的烷氧基或羧基；R7和R8均为氢原子、较低的烷基或卤素；以及其药学上可接受的盐和酯，可用于治疗或预防急性或慢性神经退行性疾病或病症，如阿尔茨海默病、帕金森病、亨廷顿舞蹈病、多发性硬化症或急性缺血事件的后遗症，如心脏病发作、中风或头部损伤，并用于保护外周器官组织免受缺血性损伤。
• Antiperspirant cosmetics comprising specific proteins from legumes of the genus Pisum and/or Phaseolus and/or Vigna and/or Macrotyloma or from cruciferous plants of the genus Brassica and including no aluminum and/or zirconium halides and/or hydroxy halides
  申请人：Henkel AG & Co. KGaA

  公开号：US10123958B2

  公开（公告）日：2018-11-13

  The present invention relates to an antiperspirant cosmetic agent including at least one specific protein from legumes of the genus Pisum and/or Phaseolus and/or Vigna and/or Macrotyloma or from cruciferous plants of the genus Brassica and including no aluminum and/or zirconium halides and/or hydroxyhalides. The present invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) are effectively influenced, thus resulting in a significant reduction in axillary sweat even in the absence of antiperspirant aluminum salts.

  本发明涉及一种止汗化妆品剂，其中包括至少一种来自豆科植物（Pisum 和/或 Phaseolus 和/或 Vigna 和/或 Macrotyloma）或十字花科植物（Brassica）的特定蛋白质，并且不包括铝和/或卤化锆和/或羟基卤化物。本发明进一步涉及一种特定蛋白质的使用和一种减少人体出汗的非治疗方法。添加或使用所述至少一种特定蛋白质可确保汗腺受到有效影响，从而即使在没有止汗剂铝盐的情况下也能显著减少腋汗。
• Antiperspirants having increased effectiveness
  申请人：Henkel AG & Co. KGaA

  公开号：US10238594B2

  公开（公告）日：2019-03-26

  The present disclosure relates to antiperspirant cosmetic agents, in the case of which the total amount of antiperspirant compounds can be clearly reduced without the antiperspirant effect of said agents or the storage stability of said agents being impaired, comprising—in each case with respect to the total weight of the antiperspirant cosmetic agent—a) 1 to 30 wt % of at least one antiperspirant compound, b) 0.1 to 10 wt % of salicylic acid, c) at least one compound of formula (I), in which n represents 0 or 1, X represents —H, Na+, K+, or NH4+, R1 is selected from —H, —COOX, or —(CH2)—COOX, R2 is selected from —H, C1-10 alkyl, or COOX, R3 is selected from —(CH2)—COOX, —(CH2)2-N[(CH2)—COOX]2, —CH(R1)—COOX, —(CH2)2-NH[CH(COOX)(CH2COOX)], —CH(R4)—C(R5)(R6)—COOX, R4 is selected from —H, C1-10 alkyl, or COOX, and R5 and R6 are, independently of each other, —H, —OH, or C1-10 alkyl.

  本公开涉及止汗剂化妆品制剂，其中止汗剂化合物的总量可明显减少，而不会损害所述制剂的止汗效果或所述制剂的贮存稳定性，包括--在每种情况下相对于止汗剂化妆品制剂的总重量--a) 1 至 30 wt % 的至少一种止汗剂化合物，b) 0.1 至 10 wt % 的水杨酸，c) 至少一种式 (I) 化合物，其中 n 代表 0 或 1，X 代表 -H、Na+、K+ 或 NH4+，R1 选自 -H、-COOX 或 -(CH2)-COOX，R2 选自 -H、C1-10 烷基或 COOX、R3 选自-( )-COOX、-( )2-N[( )-COOX]2、-CH(R1)-COOX、-( )2-NH[CH(COOX)( COOX)]、-CH(R4)-C(R5)(R6)-COOX，R4 选自-H、C1-10 烷基或 COOX，R5 和 R6 相互独立地为-H、-OH 或 C1-10 烷基。
• Cosmetic antiperspirants with alkylsuphonic acids
  申请人：Henkel AG & Co. KGaA

  公开号：US10357446B2

  公开（公告）日：2019-07-23

  The present invention concerns a cosmetic antiperspirant composition comprising at least one substance selected from the group consisting of cosmetic oils which are liquid at 20° C. and 1,013 hPa, odorants and waxes, at least one antiperspirant aluminum salt in a total amount of 1 to 80 wt %, based on the total weight of the cosmetic antiperspirant composition, and at least one compound of the formula (S-I), in which X+ is H+, Li+, Na+, K+, NH4+, ½ Mg2+, ½ Ca2+, ½ Mn2+, ½ Zn2+, ⅓ Al3+, ¼ Zr4+ or at least one antiperspirant aluminum salt and R1 is a linear or branched, saturated or unsaturated alkyl group having 1 to 10 carbon atoms, the addition of the at least one compound of the formula (S-I) resulting in effective activation of the at least one antiperspirant aluminum salt, in eminent stabilization of this activated state and in outstanding sweat diminution.

  本发明涉及一种化妆品止汗剂组合物，该组合物包含至少一种选自化妆品油（在 20° C.和 1,013 hPa 下呈液态的化妆品油、气味剂和蜡，至少一种止汗剂铝盐，其总量为 1 至 80 wt %（基于化妆品止汗剂组合物的总重量），以及至少一种式 (S-I) 的化合物，其中 X+ 是 H+、Li+、Na+、K+、NH4+、½ Mg2+、½ Ca2+、½ Mn2+、½ Zn2+、⅓ Al3+、¼ Zr4+ 或至少一种止汗剂铝盐，且 R1 是具有 1 至 10 个碳原子的直链或支链、饱和或不饱和烷基，加入至少一种式（S-I）化合物可有效活化至少一种止汗剂铝盐，显著稳定这种活化状态，并明显减少出汗。