An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones
作者:Soumendranath Mukhopadhyay、Subhas Chandra Pan
DOI:10.1039/c8ob01399c
日期:——
The first organocatalytic asymmetric Mannichreaction employing 3,4-dihydro-2-quinolones has been developed for the synthesis of biologically important 3,3-disubstituted-dihydro-2-quinolones. N-Boc imine precursor amidosulfones as well as pre-formed N-Boc imine were used for this purpose. Cyclohexyldiamine derived bifunctional amino-thiourea catalysts were employed to provide the products in high enantio-