1-氯-10-碘癸烷 | 57152-87-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 中文名称: 1-氯-10-碘癸烷
• 英文名称: 1-chloro-10-iododecane
• 英文别名: 1-Chlor-10-iod-decan
• CAS: 57152-87-1
• 化学式: C₁₀H₂₀ClI
• 分子量: 302.626
• InChiKey: YJMLTXCVCADMHF-UHFFFAOYSA-N

物化性质

• 沸点：
  301.7±10.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903799090

反应信息

• 作为反应物：
  描述：

  1-氯-10-碘癸烷 生成 14-Hydroxy-octadec-12-insaeure-methylester
  参考文献：
  名称：

  具有平滑肌刺激活性的脂肪酸的合成。

  摘要：

  DOI：

  10.1021/jm00325a010
• 作为产物：
  描述：

  1,10-癸二醇 在 吡啶 、 氯化亚砜 、 丙酮 、 sodium iodide 作用下， 生成 1-氯-10-碘癸烷
  参考文献：
  名称：

  A Study of n-Octadecenoic Acids. I. Synthesis of cis- and trans-7- through 12- and of 17-Octadecenoic Acids¹

  摘要：

  DOI：

  10.1021/ja01150a087

文献信息

• 1-HALOALKADIENE AND A PROCESS FOR PREPARING THE SAME AND A PROCESS FOR PREPARING (9e, 11z)-9,11-HEXADECADIENYL ACETATE
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20190322614A1

  公开（公告）日：2019-10-24

  A process to prepare (9E,11Z)-9,11-hexadecadienyl acetate with a good yield and high purity of the general formula (1): CH 3 —(CH 2 ) 3 —CH═CH—CH═CH—(CH 2 ) a —X.=The process includes a step of conducting a Wittig reaction between a haloalkenal of the general formula (2): OHC—CH═CH—(CH 2 ) a —X, and a triarylphosphonium pentylide of the general formula (3): CH 3 —(CH 2 ) 3 —CH − —P + Ar 3 , to obtain the 1-haloalkadiene, and the use of a (7E,9Z)-1-halo-7,9-tetradecadiene obtained by the process for a process of preparing (9E, 11Z)-9,11-hexadecadienyl acetate.

  一种制备（9E,11Z）-9,11-十六烯基乙酸酯的方法，具有良好产率和高纯度，通式如下（1）：CH3—(CH2)3—CH═CH—CH═CH—( )a—X。该方法包括进行维特格反应的步骤，反应物为通式（2）：OHC—CH═CH—( )a—X的卤代烯醛，与通式（3）： —( )3—CH−—P+Ar3的三芳基膦五元阴离子，以获得1-卤代烯烃，并利用该方法获得的（7E,9Z）-1-卤代-7,9-十四烯烃，用于制备（9E,11Z）-9,11-十六烯基乙酸酯的方法。
• Deiodinative fluorination of alkyl iodide with p -iodotoluene difluoride
  作者：Masanori Sawaguchi、Shoji Hara、Yutaka Nakamura、Shinichi Ayuba、Tsuyoshi Fukuhara、Norihiko Yoneda

  DOI：10.1016/s0040-4020(01)00201-0

  日期：2001.4

  Oxidative fluorination of alkyl iodides with p-iodotoluene difluoride (4) was carried out. In the presence of Et3N–4HF, the fluorination reaction of prim-alkyl iodides selectively took place at the iodine position under mild conditions to give the corresponding alkyl fluorides in good yields.

  用对碘代甲苯二氟化物（4）对烷基碘进行氧化氟化。在Et 3 N–4HF的存在下，伯烷基碘化物的氟化反应在温和条件下在碘位置上选择性发生，从而以高收率得到相应的烷基氟化物。
• Transition metal compound, polymerization-initiator system comprising the same, and process for producing polymer
  申请人：Uemura Makoto

  公开号：US20070270521A1

  公开（公告）日：2007-11-22

  A transition metal compound represented by the formula, [(CpR 1 m )(CO) 2 M 1 ][M 2 (CO) 2 (CpR 2 n )], wherein Cp is a cyclopentadienyl ring, R 1 and R 2 are independently of each other a hydrocarbyl group having 1 to 20 carbon atoms, and each of at least one R 1 and at least one R 2 is a hydrocarbyl group having 5 to 20 carbon atoms, m and n are independently of each other an integer of 1 to 5, and M 1 and M 2 are independently of each other a transition metal atom of the group 8 in the periodic table of elements; a polymerization-initiator system comprising said transition metal compound; and a process for producing a polymer in the presence of the polymerization-initiator system.

  一个由该公式表示的过渡金属化合物，[(CpR1m)(CO)2M1][M2(CO)2(CpR2n)]，其中Cp是一个环戊二烯环，R1和R2是独立的烃基团，含有1至20个碳原子，至少一个R1和至少一个R2是含有5至20个碳原子的烃基团，m和n是独立的1至5的整数，M1和M2是元素周期表中8族的过渡金属原子；包括所述过渡金属化合物的聚合物化引发剂系统；以及在聚合物化引发剂系统存在的情况下生产聚合物的过程。
• MITOCHONDRIA TARGETED CATIONIC ANTI-OXIDANT COMPOUNDS FOR PREVENTION, THERAPY OR TREATMENT OF HYPER-PROLIFERATIVE DISEASE, NEOPLASIAS AND CANCERS
  申请人：Zarling David A.

  公开号：US20110059922A1

  公开（公告）日：2011-03-10

  The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked to nitroxide or linked to hydroxylamine anti-oxidant groups.

  披露的发明包括使用含有脂溶性阳离子基团与亚硝酰基或羟胺抗氧化基团相连的药用盐来治疗癌症和相关的新生物病变，特别是前列腺癌的方法。
• Syntheses, optical properties, and bioapplications of the aggregation-induced emission of 2,3,4,5-tetraphenylcyclopenta-2,4-dienyl benzene derivatives
  作者：Franklin Anariba、Leng Leng Chng、Nur Sharalyn Abdullah、Francis E. H. Tay

  DOI：10.1039/c2jm32755d

  日期：——

  Syntheses of 2,3,4,5-tetraphenylcyclopenta-2,4-dienyl benzene derivatives tailored with seven substituents of various lengths and molecular composition were accomplished and their UV-Vis and fluorescence properties investigated. All of the novel fluorescent dyes displayed varying degrees of aggregation-induced emission (AIE) in the blue region of ∼460 nm in various organic and aqueous solvents. Interestingly, the studies revealed the novel ability of this family of molecules to show strong luminescence in both organic solvents (e.g., %Φf = 69.0% in toluene) and aqueous solutions (e.g., %Φf = 14.0% in H2O) without the need to mix organic and aqueous solvents. Furthermore, fluorescence properties as a function of temperature indicated that both aggregation-induced behavior and the initial degree of solubility played an important role in the overall observed properties of the fluorescent dyes. The importance of this family of molecules for nucleic acid detection and bioimaging applications was demonstrated via the “turn off” detection of cDNA and ss-DNA and by successful tagging and imaging of lens epithelial cells. Taken together, these findings are of great importance for they provide a platform for further rational design and synthesis of luminescent (due to aggregation-induced) and biocompatible (non-toxic) nanoparticles for a wide range of imaging and sensory applications.

  我们合成了由七个不同长度和分子组成的取代基定制的 2,3,4,5- 四苯基环戊-2,4-二烯苯衍生物，并研究了它们的紫外可见光和荧光特性。在各种有机溶剂和水溶剂中，所有新型荧光染料在 ∼460 纳米的蓝色区域都显示出不同程度的聚集诱导发射（AIE）。有趣的是，研究揭示了这一分子家族的新能力，即在有机溶剂中（如在甲苯中，%Φf = 69.0%）和水溶液中（如在 H2O 中，%Φf = 14.0%）都能显示出强烈的发光，而无需混合有机溶剂和水溶液。此外，荧光特性与温度的函数关系表明，聚合引起的行为和初始溶解度对荧光染料的整体观察特性起着重要作用。通过对 cDNA 和 ss-DNA 的 "关闭 "检测，以及对晶状体上皮细胞的成功标记和成像，证明了这一系列分子在核酸检测和生物成像应用方面的重要性。总之，这些发现非常重要，因为它们为进一步合理设计和合成发光（由于聚集诱导）和生物相容性（无毒）纳米粒子提供了一个平台，可用于广泛的成像和感官应用。