methyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate | 1333225-31-2

分子结构分类

有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮

中文名称

——

中文别名

——

英文名称

methyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate

英文别名

Methyl 5-bromo-2-(4-fluorophenyl)-1-benzofuran-3-carboxylate

methyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate化学式

CAS

1333225-31-2

化学式

C₁₆H₁₀BrFO₃

mdl

——

分子量

349.156

InChiKey

GSBFPXKKYLRXDI-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

熔点：

146.7 °C
沸点：

449.2±45.0 °C(predicted)
密度：

1.518±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

辛醇/水分配系数(LogP)：

4.6
重原子数：

21
可旋转键数：

3
环数：

3.0
sp3杂化的碳原子比例：

0.06
拓扑面积：

39.4
氢给体数：

0
氢受体数：

4

上下游信息

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	methyl 6-amino-5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate	1333225-33-4	C₁₆H₁₁BrFNO₃	364.171
——	methyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate	1333225-32-3	C₁₆H₉BrFNO₅	394.154
——	methyl 5-bromo-2-(4-fluorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylate	1333225-34-5	C₁₇H₁₃BrFNO₅S	442.262
——	5-bromo-2-(4-fluoro-phenyl)-6-methanesulfonylamino-benzofuran-3-carboxylic acid	1333244-32-8	C₁₆H₁₁BrFNO₅S	428.235
——	methyl 5-bromo-2-(4-fluorophenyl)-6-(phenylsulfonamido)benzofuran-3-carboxylate	1333244-36-2	C₂₂H₁₅BrFNO₅S	504.333
——	methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)benzofuran-3-carboxylate	1333225-35-6	C₁₈H₁₅BrFNO₅S	456.289
——	5-bromo-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)-1-benzofuran-3-carboxylic acid	1333225-19-6	C₁₇H₁₃BrFNO₅S	442.262
——	methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate	1333244-37-3	C₂₃H₁₇BrFNO₅S	518.36
——	5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid	1333244-38-4	C₂₂H₁₅BrFNO₅S	504.333
——	5-bromo-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide	1333244-33-9	C₁₇H₁₄BrFN₂O₄S	441.278
——	5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333225-20-9	C₁₈H₁₆BrFN₂O₄S	455.304
——	5-bromo-2-(4-fluorophenyl)-6-(N-(3-hydroxypropyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide	1333244-34-0	C₂₀H₂₀BrFN₂O₅S	499.358
——	5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-(2-morpholinoethyl)methylsulfonamido)benzofuran-3-carboxamide	1333244-35-1	C₂₃H₂₅BrFN₃O₅S	554.437
——	5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide	1333244-39-5	C₂₃H₁₈BrFN₂O₄S	517.375
——	2-(4-fluorophenyl)-5-(4-hydroxyphenyl)-N-methyl-6-(methyl(methylsulfonyl)amino)-1-benzofuran-3-carboxamide	1333224-46-6	C₂₄H₂₁FN₂O₅S	468.506
——	2-(4-fluorophenyl)-5-(3-formylphenyl)-N-methyl-6-(methyl(methylsulfonyl)amino)-1-benzofuran-3-carboxamide	1333225-36-7	C₂₅H₂₁FN₂O₅S	480.517
——	5-(3-aminophenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333244-28-2	C₂₄H₂₂FN₃O₄S	467.521
——	2-(4-fluorophenyl)-5-(3-(isoquinolin-6-yl)phenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333243-80-3	C₃₃H₂₆FN₃O₄S	579.652
——	2-(4-fluorophenyl)-5-(3-iodophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333244-29-3	C₂₄H₂₀FIN₂O₄S	578.403
——	(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)boronic acid	1621705-60-9	C₁₈H₁₈BFN₂O₆S	420.226
——	2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-nitrophenyl)benzofuran-3-carboxamide	1333244-27-1	C₂₄H₂₀FN₃O₆S	497.504
——	2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzofuran-3-carboxamide	1333244-30-6	C₃₀H₃₂BFN₂O₆S	578.469
——	5-(3-(benzo[b]thiophen-2-yl)phenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333243-55-2	C₃₂H₂₅FN₂O₄S₂	584.692
——	5-(3-(3H-imidazo[4,5-b]pyridin-2-yl)phenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333243-02-9	C₃₀H₂₄FN₅O₄S	569.616
——	2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)benzofuran-3-carboxamide	1333241-35-2	C₃₀H₂₃FN₄O₅S	570.601
——	2-(4-fluorophenyl)-6-(N-(3-hydroxypropyl)methylsulfonamido)-N-methyl-5-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)benzofuran-3-carboxamide	1333244-00-0	C₃₂H₂₇FN₄O₆S	614.654
——	5-[3-(1,1-dioxo-2,3-dihydro-1-benzothiophen-2-yl)phenyl]-2-(4-fluorophenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide	1333243-79-0	C₃₂H₂₇FN₂O₆S₂	618.707
——	2-(4-fluorophenyl)-N-methyl-6-(N-(2-morpholinoethyl)methylsulfonamido)-5-(3-(oxazolo[4,5-b]pyridine-2-yl)phenyl)benzofuran-3-carboxamide	1333244-13-5	C₃₅H₃₂FN₅O₆S	669.733
——	5-(3-(benzo[d]thiazol-2-yl)phenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-1-benzofuran-3-carboxamide	1333224-64-8	C₃₁H₂₄FN₃O₄S₂	585.68
——	5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide	1333241-64-7	C₃₂H₂₅F₂N₃O₆S	617.63
——	5-(3-(4-cyanobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide	1333244-21-5	C₃₃H₂₅FN₄O₆S	624.649
——	5-(3-(6-cyanobenzo[d]thiazol-2-yl)phenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333242-91-3	C₃₂H₂₃FN₄O₄S₂	610.689
——	2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)-5-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)benzofuran-3-carboxamide	1333244-16-8	C₃₅H₂₅FN₄O₅S	632.672
——	5-[3-(1,1-dioxo-1-benzothiophen-2-yl)phenyl]-2-(4-fluorophenyl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide	1333243-78-9	C₃₂H₂₅FN₂O₆S₂	616.691
——	5-(3-(6-(aminomethyl)benzo[d]thiazol-2-yl)phenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide	1333243-00-7	C₃₂H₂₇FN₄O₄S₂	614.721
——	MK-8876	1426960-33-9	C₃₂H₂₄F₂N₄O₅S	614.629

反应信息

作为反应物：

描述：

methyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 吡啶、 ammonium hydroxide 、