(E,E,E,E)-6,10,14,18,22-pentamethyltricosa-5,9,13,17,21-pentaen-1-yne | 257885-50-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E,E,E,E)-6,10,14,18,22-pentamethyltricosa-5,9,13,17,21-pentaen-1-yne
• 英文别名: (all-E)-2,6,10,14,18-pentamethyl-2,6,10,14,18-tricosapentaen-22-yne；(5E,9E,13E,17E)-6,10,14,18,22-pentamethyltricosa-5,9,13,17,21-pentaen-1-yne
• CAS: 257885-50-0
• 化学式: C₂₈H₄₄
• 分子量: 380.657
• InChiKey: LDLNZOJTPGIQTC-XLZCZPQRSA-N

物化性质

• 沸点：
  471.7±24.0 °C(Predicted)
• 密度：
  0.862±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  28
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (E,E,E,E)-6,10,14,18,22-pentamethyltricosa-5,9,13,17,21-pentaen-1-yne 在 二氯二茂锆 、 叔丁基锂 作用下， 以 乙醚 、 1,2-二氯乙烷 、 正戊烷 为溶剂， 反应 8.25h， 生成 (all-E)-6,10,14,18,22,26,30,34,38-nonamethyl-1-trimethylsilyl-5,9,13,17,21,25,29,33,37-nonacontanonaen-1-yne
  参考文献：
  名称：

  A Novel, Highly Selective, and General Methodology for the Synthesis of 1,5-Diene-Containing Oligoisoprenoids of All Possible Geometrical Combinations Exemplified by an Iterative and Convergent Synthesis of Coenzyme Q₁₀

  摘要：

  GRAPHICSA truly general, versatile, and highly regio- and stereoselective methodology for the synthesis of terpenoids containing 1,5-diene units of E and/or Z geometry critically involves Pd-catalyzed homoallyl- and homopropargyl-alkenyl coupling and Zr-catalyzed carboalumination of alkynes. By using this methodology, coenzyme Q(10), (E,Z,E)-geranylgeranoll, and other natural or unnatural compounds have been synthesized efficiently.

  DOI：

  10.1021/ol010263d
• 作为产物：
  描述：

  (5E,9E)-12-iodo-6,10-dimethyl-1-trimethylsilyl-5,9-dodecadien-1-yne 在 氢氧化钾 、 水 、 叔丁基锂 作用下， 以 甲醇 、 乙醚 、 正戊烷 为溶剂， 反应 3.0h， 生成 (E,E,E,E)-6,10,14,18,22-pentamethyltricosa-5,9,13,17,21-pentaen-1-yne
  参考文献：
  名称：

  A Novel, Highly Selective, and General Methodology for the Synthesis of 1,5-Diene-Containing Oligoisoprenoids of All Possible Geometrical Combinations Exemplified by an Iterative and Convergent Synthesis of Coenzyme Q₁₀

  摘要：

  GRAPHICSA truly general, versatile, and highly regio- and stereoselective methodology for the synthesis of terpenoids containing 1,5-diene units of E and/or Z geometry critically involves Pd-catalyzed homoallyl- and homopropargyl-alkenyl coupling and Zr-catalyzed carboalumination of alkynes. By using this methodology, coenzyme Q(10), (E,Z,E)-geranylgeranoll, and other natural or unnatural compounds have been synthesized efficiently.

  DOI：

  10.1021/ol010263d

文献信息

• A Convergent Approach to Coenzyme Q
  作者：Bruce H. Lipshutz、Gerd Bulow、Fernando Fernandez-Lazaro、Sung-Kyu Kim、Richard Lowe、Paul Mollard、Kirk L. Stevens

  DOI：10.1021/ja992164p

  日期：1999.12.1

  Syntheses of coenzyme Q(3-8) are described, as well as related systems such as plastoquinone-5. Preparation of thr higher homologues of the ubiquinones relies on two new conjunctive reagents, or "linchpins", each of which ultimately corresponds to two or three prenyl units. These allow for attachment of a polyprenyl halide at one end, followed by a Ni(0)-catalyzed cross-coupling at the other terminus with a chloromethylated p-quinone.