4-氨基甲苯-2-磺酸 | 118-88-7

• 物质功能分类: 有机原料 - 氨基化合物 - 磺酸类氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基甲苯-2-磺酸
• 中文别名: 5-氨基-2-甲基苯磺酸；2-甲基-5-氨基苯磺酸；异4B酸；对甲苯胺-3-磺酸
• 英文名称: 4-amino-toluene-2-sulfonic acid
• 英文别名: 5-amino-2-methylbenzenesulfonic acid
• CAS: 118-88-7
• 化学式: C₇H₉NO₃S
• mdl: MFCD00007911
• 分子量: 187.219
• InChiKey: BRKFTWHPLMMNHF-UHFFFAOYSA-N

物化性质

• 熔点：
  200°C
• 沸点：
  500°C (rough estimate)
• 密度：
  1.3553 (rough estimate)
• 溶解度：
  可溶于酸性水溶液（轻微、加热、超声处理）、碱水溶液（轻微、超声处理）
• 解离常数：
  0-0 at 23℃
• 物理描述：
  DryPowder
• 稳定性/保质期：
  避免与氧化物和水分接触。

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• TSCA：
  Yes
• 危险等级：
  8
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R20/21/22
• 危险品运输编号：
  2585
• 海关编码：
  2921430090
• 包装等级：
  III
• 危险类别：
  8
• 储存条件：
  密封于阴凉、干燥处保存。确保工作间具有良好的通风设施。存储地点应远离氧化剂、火源和水源。

SDS

Name:	4-Aminotoluene-2-sulfonic acid 97% Material Safety Data Sheet
Synonym:
CAS:	118-88-7

Section 1 - Chemical Product MSDS Name:4-Aminotoluene-2-sulfonic acid 97% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
118-88-7	4-Aminotoluene-2-sulfonic acid	97	204-282-8

Hazard Symbols: C
Risk Phrases: 34

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.Hygroscopic (absorbs moisture from the air).Corrosive.
Potential Health Effects
Eye:
Causes eye irritation. Causes severe eye burns. Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns.
Inhalation:
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. Causes chemical burns to the respiratory tract.
Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Use with adequate ventilation. Use only in a chemical fume hood. Discard contaminated shoes.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store in a tightly closed container. Corrosives area. Store protected from moisture.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 118-88-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin. Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: weak odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: > 200 deg C
Autoignition Temperature: > 500 deg C (> 932.00 deg F)
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble in water
Specific Gravity/Density:
Molecular Formula:
Molecular Weight: 187.22

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Nitrogen oxides, sulfur dioxide, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 118-88-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-Aminotoluene-2-sulfonic acid - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: ARYLSULPHONIC ACIDS, SOLID
Hazard Class: 8
UN Number: 2583
Packing Group: II
IMO
Shipping Name: ARYLSULPHONIC ACIDS, SOLID
Hazard Class: 8
UN Number: 2583
Packing Group: II
RID/ADR
Shipping Name: ARYLSULPHONIC ACIDS, SOLID
Hazard Class: 8
UN Number: 2583
Packing group: II

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 25 Avoid contact with eyes.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 118-88-7: 2
Canada
CAS# 118-88-7 is listed on Canada's NDSL List.
CAS# 118-88-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 118-88-7 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途：主要用作合成颜料红57#的添加剂以及蓝色相调节剂。

反应信息

• 作为反应物：
  描述：

  4-氨基甲苯-2-磺酸 生成 苯磺酸,5-氯-2-甲基-
  参考文献：
  名称：

  Jenssen, Justus Liebigs Annalen der Chemie, 1874, vol. 172, p. 235

  摘要：

  DOI：
• 作为产物：
  描述：

  4-硝基甲苯-2-磺酸 在 iron(II,III) oxide 、 四丁基溴化铵 、 铁粉 、 iron(II) chloride 、 ammonium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 反应 1.5h， 以98.75%的产率得到4-氨基甲苯-2-磺酸
  参考文献：
  名称：

  一种还原硝基芳香族取代物制备氨基芳香族取代物的方法

  摘要：

  本发明涉及氨基芳香族取代物合成技术领域，具体公开一种还原硝基芳香族取代物制备氨基芳香族取代物的方法。该方法包括以下步骤，将水、催化剂加入到第一反应器中，并将所述反应器升温，加入还原铁剂，调节pH，同时将硝基芳香族取代物加入到第一反应器中，保温反应，得反应料液；调节反应料液的pH，保温反应，加入稳定剂，得到含有氨基芳香族取代物的第一溶液和铁黑粗品；调节第一溶液的pH，固液分离，得到氨基芳香族取代物。本发明提供的生产工艺方法简单，可连续化生产，具有较高的操作安全性以及较高的选择性，反应时间短，收率高达90％以上，产品质量好，含量达到98％以上。

  公开号：

  CN109761860A
• 作为试剂：
  描述：

  聚合甲醛 、 alkaline earth salt of/the/ methylsulfuric acid 在 4-氨基甲苯-2-磺酸 作用下， 生成 2-benzylamino-5-formyl-benzenesulfonic acid
  参考文献：
  名称：

  DE477634

  摘要：

  公开号：

文献信息

• Phenyl sulfonamide endothelin antagonists
  申请人：Bristol-Myers Squibb Co.

  公开号：US05514696A1

  公开（公告）日：1996-05-07

  Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R.sup.1, R.sup.2 and R.sup.3 are each independently (a) hydrogen, except that R.sup.1 is other than hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) --C(O)H or --C(O)R.sup.6 ; (h) --CO.sub.2 H or --CO.sub.2 R.sup.6 ; (i) --SH, --S(O).sub.n R.sup.6, --S(O).sub.m --OH, --S(O).sub.m --OR.sup.6, --O--S(O).sub.m --R.sup.6, --O--S(O).sub.m OH or --O--S(O).sub.m --OR.sup.6 ; (j) --Z.sup.4 --NR.sup.7 R.sup.8 ; or (k) --Z.sup.4 --N(R.sup.11 --Z.sup.5 --NR.sup.9 R.sup.10 ; and the remaining symbols are as defined in the specification.

  式##STR1##的化合物抑制内皮素的活性。符号的定义如下：R.sup.1，R.sup.2和R.sup.3分别独立地是(a) 氢，除了R.sup.1不是氢；(b) 烷基，烯基，炔基，烷氧基，环烷基，环烷基烷基，环烯基，环烯基烷基，芳基，芳氧基，芳基烷基或芳基烷氧基，其中任何一个可能被Z.sup.1，Z.sup.2和Z.sup.3取代；(c) 卤素；(d) 羟基；(e) 氰基；(f) 硝基；(g) --C(O)H或--C(O)R.sup.6；(h) --CO.sub.2 H或--CO.sub.2 R.sup.6；(i) --SH，--S(O).sub.n R.sup.6，--S(O).sub.m --OH，--S(O).sub.m --OR.sup.6，--O--S(O).sub.m --R.sup.6，--O--S(O).sub.m --OH或--O--S(O).sub.m --OR.sup.6；(j) --Z.sup.4 --NR.sup.7 R.sup.8；或(k) --Z.sup.4 --N(R.sup.11 --Z.sup.5 --NR.sup.9 R.sup.10；其余符号如规范中定义。
• [EN] SUBSTITUTED PYRROLOPYRIMIDINES<br/>[FR] PYRROLOPYRIMIDINES SUBSTITUÉES
  申请人：BAYER PHARMA AG

  公开号：WO2013174743A1

  公开（公告）日：2013-11-28

  The present invention relates to substituted pyrrolopyrimidine compounds general formula I : in which A, X, R1, R2, m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式I的取代吡咯吡嘧啶化合物，其中A、X、R1、R2、m和n如本文所述和定义，以制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和配方，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是治疗或预防高增殖和/或血管生成障碍的疾病，作为唯一药剂或与其他活性成分组合使用。
• 종이를 백색화하기 위한 광증백제
  申请人：Archroma IP GmbH 아르크로마 아이피 게엠베하(520140586020)

  公开号：KR20200102995A

  公开（公告）日：2020-09-01

  본 발명은 종이, 보드, 직물 및 부직포의 백색화 및 증백을 위한 광증백제, 상기 광증백제의 제조 방법, 제지 공정에서의 상기 증백제의 용도, 및 종이를 백색화하는 방법에 관한 것이다.

  本发明涉及用于白化和增白纸张、板材、纺织品和非织造布的光增白剂，该光增白剂的制备方法，增白剂在造纸工艺中的应用，以及用于白化纸张的方法。
• Process for the preparation of aminobenzenesulfonic acids
  申请人：Ciba-Geigy Corporation

  公开号：US05189206A1

  公开（公告）日：1993-02-23

  There is disclosed a process for the preparation of compounds of formula ##STR1## wherein the symbols are as defined in claim 1, which process comprises dissolving a compound of formula ##STR2## in sulfuric acid, adding this solution to oleum and reacting the mixture in the temperature range from 10.degree. to 80.degree. C. until a sulfo group has been completely introduced, and, in an optional further step, subjecting the reaction mixture to further reaction in the temperature range from 100.degree. to 200.degree. C. to introduce a second sulfo group. The compounds of formula (1) obtainable by this process are useful intermediates for the synthesis of dyes and are particularly suitable diazo components for the synthesis of azo dyes.

  本发明公开了一种制备式为##STR1##的化合物的方法，其中符号如权利要求1所定义，该方法包括将式为##STR2##的化合物溶解于硫酸中，将该溶液加入油酸中并在10℃到80℃的温度范围内反应，直到完全引入磺酰基，并在可选的进一步步骤中，在100℃到200℃的温度范围内将反应混合物进一步反应以引入第二个磺酰基。通过该方法获得的式（1）的化合物是合成染料的有用中间体，特别适用于合成偶氮染料的重要偶氮基团。
• Liberation, Feminism, and Development Communication
  作者：H. Leslie Steeves

  DOI：10.1111/j.1468-2885.2001.tb00250.x

  日期：2001.11

  This essay notes the relative neglect of considerations of both liberation and gender in the scholarship and practice of development communication. Liberation perspectives on development, grounded in religion and spirituality, argue for individual and collective empowerment, and therefore appear to offer consistency with feminist thought. In practice, it is unclear to what extent women are included or empowered in applications of liberation theology to development communication. This paper argues that the theory and practice of development communication would be strengthened by drawing on insights from both feminism and liberation theology.

  本文指出在发展传播的学术和实践中相对忽视了对解放和性别的考虑。以宗教和灵性为基础的解放发展观主张个人和集体赋权，因此似乎与女权主义思想保持一致。在实践中，尚不清楚妇女在多大程度上被纳入或赋权于解放神学在发展传播中的应用。本文认为，通过借鉴女权主义和解放神学的见解，发展传播的理论和实践将得到加强。