4',7-diallyloxy-5-hydroxygenistein

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 4',7-diallyloxy-5-hydroxygenistein
• 英文别名: 5-hydroxy-7-prop-2-enoxy-3-(4-prop-2-enoxyphenyl)chromen-4-one
• 化学式: C₂₁H₁₈O₅
• 分子量: 350.371
• InChiKey: ZYIRKGFBHLSXRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  染料木素 、 3-溴丙烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以77.5%的产率得到4',7-diallyloxy-5-hydroxygenistein
  参考文献：
  名称：

  Synthesis and cytotoxic activity of genistein derivatives

  摘要：

  A series of genistein derivatives was prepared and tested in vitro against leukocythemia (HL-60), colorectal adenocarcinoma (HT-29), and human gastric adenocarcinoma (SGC-7901) cell lines. Among these derivatives, 4',5-di-n-octoxy-7-gem-difluoromethylenegenistein, 9f, had the strongest activity against HL-60, HT-29, and SGC-7901 cells.

  DOI：

  10.1007/s00044-009-9271-z

文献信息

• ISOFLAVONES FOR TREATING MUCOPOLYSACCHARIDOSES
  申请人：GRYNKIEWICZ Grzegorz

  公开号：US20120190642A1

  公开（公告）日：2012-07-26

  A method of treatment of mucopolysaccharidosis, the method including administering to a patient in the need of such treatment—a therapeutically effective amount of a natural isoflavone of formula (I), a derivative thereof, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition including a pharmaceutically acceptable excipient; and a natural isoflavone of formula (I), a derivative thereof, or a pharmaceutically acceptable salt thereof, the natural isoflavone, the derivative thereof, or the pharmaceutically acceptable salt thereof being in a therapeutically effective amount for the treatment of mucopolysaccharidosis.
• US8178609B2
  申请人：——

  公开号：US8178609B2

  公开（公告）日：2012-05-15
• US8623910B2
  申请人：——

  公开号：US8623910B2

  公开（公告）日：2014-01-07