R-(Z)-12-羟基-9-十八烯酸1,2,3-丙三醇酯 | 141-08-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: R-(Z)-12-羟基-9-十八烯酸1,2,3-丙三醇酯
• 中文别名: 单蓖麻油酸甘油酯；(9Z,12R)-12-羟基-9-十八碳烯酸 2,3-二羟基丙基酯；(9Z,12R)-12-羟基-9-十八碳烯酸2,3-二羟基丙基酯；(9Z,12R)-12-羟基-9-十八碳烯酸-2,3-二羟基丙酯；甘油蓖麻醇酸酯
• 英文名称: glycerol monoricinoleate
• 英文别名: glycerol ricinoleate；1-monoricinolein；glyceryl monoricinoleate；(Ξ)-3-(D-12-hydroxy-octadec-9c-enoyloxy)-propane-1,2-diol；(Ξ)-3-(D-12-Hydroxy-octadec-9c-enoyloxy)-propan-1,2-diol；(Ξ)-O¹-((R)-Ricinoloyl)-glycerin；2,3-dihydroxypropyl (Z,12R)-12-hydroxyoctadec-9-enoate
• CAS: 141-08-2；1323-38-2
• 化学式: C₂₁H₄₀O₅
• 分子量: 372.546
• InChiKey: HDIFHQMREAYYJW-XGXNLDPDSA-N

物化性质

• 密度：
  0.99-1.01 g/cm3(Temp: 15 °C)
• LogP：
  4.713 (est)
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  R-(Z)-12-羟基-9-十八烯酸1,2,3-丙三醇酯 、 苯甲酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Stereodivergent synthesis of both (2S)- and (2R)-1-monoricinolein derivatives by lipase-catalyzed hydrolysis or transesterification directed to new ferroelectric liquid crystals

  摘要：

  The preparation of both (2S)- and (2R)-1-monoricinolein derivatives has been developed to synthesize ferroelectric liquid crystals. Lipase-catalyzed hydrolysis of 2-protected-1,3-diricinoleins provided (2S)-1-monoricinolein derivatives with high diastereoselectivities, while transesterification of 2-protected glycerols with vinyl recinoleate gave (2R)-1-monoricinolein counterparts in good yields with high diastereoselectivities. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.04.009
• 作为产物：
  描述：

  R-(Z)-12-羟基-9-十八烯酸与1,2,3-丙三醇的二酯 在 PS lipase 作用下， 以 四氢呋喃 、 phosphate buffer 为溶剂， 反应 0.67h， 以50%的产率得到R-(Z)-12-羟基-9-十八烯酸1,2,3-丙三醇酯
  参考文献：
  名称：

  Stereodivergent synthesis of both (2S)- and (2R)-1-monoricinolein derivatives by lipase-catalyzed hydrolysis or transesterification directed to new ferroelectric liquid crystals

  摘要：

  The preparation of both (2S)- and (2R)-1-monoricinolein derivatives has been developed to synthesize ferroelectric liquid crystals. Lipase-catalyzed hydrolysis of 2-protected-1,3-diricinoleins provided (2S)-1-monoricinolein derivatives with high diastereoselectivities, while transesterification of 2-protected glycerols with vinyl recinoleate gave (2R)-1-monoricinolein counterparts in good yields with high diastereoselectivities. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.04.009

文献信息

• [EN] PHENOTHIAZINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE ET LEURS UTILISATIONS
  申请人：CAMP4 THERAPEUTICS CORP

  公开号：WO2019195789A1

  公开（公告）日：2019-10-10

  The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).

  本发明提供了吩噻嗪化合物，其制备方法，包含该化合物的药物组合物，以及在治疗各种疾病或症状中使用该化合物或组合物，例如核糖体紊乱和核糖体病，例如钻石-布莱克范贫血（DBA）。
• HAIR COLORING COMPOSITIONS
  申请人：——

  公开号：US20020032933A1

  公开（公告）日：2002-03-21

  A hair coloring composition comprising: (a) from about 0.0003 moles (per 100 g of composition) to less than about 0.09 moles (per 100 g of composition) of an inorganic peroxygen oxidizing agent; and (b) an oxidative hair coloring agent; wherein the pH of each of (a) and (b) is in the range of from about 1 to about 6 and wherein the combined mixture of (a) and (b) has a pH in the range of from about 1 to about 6. The products can provide excellent hair coloring and in-use efficacy benefits including excellent initial color and good wash fastness in combination with reduced hair damage at low pH.

  一种染发组合物，包括：(a)约0.0003摩尔（每100克组合物）至约0.09摩尔（每100克组合物）的无机过氧化氧化剂；和(b)氧化性染发剂；其中(a)和(b)的pH值在约1至约6的范围内，且(a)和(b)的混合物的pH值在约1至约6的范围内。该产品可以提供出色的染发效果和使用效果，包括出色的初始颜色和良好的耐洗性，同时在低pH值下减少头发损伤。
• [EN] PHARMAACEUTICAL COMPOSITIONS COMPRISING FATTY ACID ESTERS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES ESTERS D'ACIDES GRAS
  申请人：ALKERMES PHARMA IRELAND LTD

  公开号：WO2013142198A1

  公开（公告）日：2013-09-26

  The present invention relates to an injectable, pharmaceutical composition comprising a C1-6 alkyl ester of a C10-20 fatty acid. In an embodiment, the fatty acid is ethyl oleate, isopropyl oleate, ethyl myristate, or isopropyl myristate. These compositions are useful for the delivery of anti-psychotic drugs.

  本发明涉及一种可注射的药物组合物，包括C10-20脂肪酸的C1-6烷基酯。在一种实施例中，脂肪酸为油酸乙酯、油酸异丙酯、肉豆蔻酸乙酯或肉豆蔻酸异丙酯。这些组合物适用于抗精神病药物的输送。
• [EN] PHARMACEUTICAL COMPOSITIONS COMPRISING BENZYL ALCOHOL<br/>[FR] COMPOSITIONS PHARMACEUTIQUES COMPRENANT DE L'ALCOOL BENZYLIQUE
  申请人：ALKERMES PHARMA IRELAND LTD

  公开号：WO2013142205A1

  公开（公告）日：2013-09-26

  The present invention relates to a pharmaceutical composition comprising benzyl alcohol and polyoxyethylene derivatives of sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.

  本发明涉及一种药物组合物，包括苯甲醇和羧酸山梨醇酯的聚氧乙烯衍生物，用于输送抗精神病药物。
• [EN] THERAPUETIC USES OF SELECTED PYRIMIDINE COMPOUNDS WITH ANTI-MER TYROSINE KINASE ACTIVITY<br/>[FR] UTILISATIONS THÉRAPEUTIQUES DE COMPOSÉS SÉLECTIONNÉS DE PYRIMIDINE AYANT UNE ACTIVITÉ TYROSINE KINASE ANTIMÈRE
  申请人：UNIV NORTH CAROLINA

  公开号：WO2015157127A1

  公开（公告）日：2015-10-15

  Uses of pyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK -/- tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.

  将嘧啶类化合物用作抗Mer酪氨酸激酶活性的抗感染剂、免疫刺激剂和免疫调节剂、抗癌剂（包括对MerTK -/-肿瘤和急性髓样白血病（AML）的ITD和TKD突变形式），以及作为辅助剂与化疗、放疗或其他肿瘤标准治疗联合使用。