7-Hydroxy-3-[4-(2-methyloxyphenyloxyacethy)phenyl]-4H-benzopyran-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-Hydroxy-3-[4-(2-methyloxyphenyloxyacethy)phenyl]-4H-benzopyran-4-one
• 英文别名: 7 - hydroxy-3 - [4 - (4 - methoxybenzene oxygen acetyl amino) phenyl] - 4H - benzopyran-4 - one；N-[4-(7-hydroxy-4-oxochromen-3-yl)phenyl]-2-(2-methoxyphenoxy)acetamide
• 化学式: C₂₄H₁₉NO₆
• 分子量: 417.418
• InChiKey: BJIJVVOTAGZMIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-Hydroxy-3-[4-(2-methyloxyphenyloxyacethy)phenyl]-4H-benzopyran-4-one 、 乙酰氯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以84.4%的产率得到7-acetoxy-3-[4-(2-methoxybenzeneoxyacetylamino)phenyl]-4H-benzopyran-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities

  摘要：

  A series of isoflavone amides were designed with isoflavone in place of the scaffold of 2-arylbenzoxazole as cholesterol ester transfer protein (CETP) inhibitors. Twelve new compounds were synthesized, and their inhibitory activities of CETP and preadipocyte proliferation were assayed. The hypolipidemic potency of the most effective compound HY-2c was further tested in vivo by hamster. The results indicate that HY-2c exhibited favorable antihyperlipidemic and preadipocyte antiproliferative activities. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.06.032
• 作为产物：
  描述：

  2-甲氧基苯氧乙酸 在 吡啶 、 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 7-Hydroxy-3-[4-(2-methyloxyphenyloxyacethy)phenyl]-4H-benzopyran-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities

  摘要：

  A series of isoflavone amides were designed with isoflavone in place of the scaffold of 2-arylbenzoxazole as cholesterol ester transfer protein (CETP) inhibitors. Twelve new compounds were synthesized, and their inhibitory activities of CETP and preadipocyte proliferation were assayed. The hypolipidemic potency of the most effective compound HY-2c was further tested in vivo by hamster. The results indicate that HY-2c exhibited favorable antihyperlipidemic and preadipocyte antiproliferative activities. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.06.032

文献信息

• Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities
  作者：Wenbin Wang、Yi He、Pei Xu、Qidong You、Hong Xiao、Hua Xiang

  DOI：10.1016/j.bmc.2015.06.032

  日期：2015.8

  A series of isoflavone amides were designed with isoflavone in place of the scaffold of 2-arylbenzoxazole as cholesterol ester transfer protein (CETP) inhibitors. Twelve new compounds were synthesized, and their inhibitory activities of CETP and preadipocyte proliferation were assayed. The hypolipidemic potency of the most effective compound HY-2c was further tested in vivo by hamster. The results indicate that HY-2c exhibited favorable antihyperlipidemic and preadipocyte antiproliferative activities. (C) 2015 Elsevier Ltd. All rights reserved.