1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them
申请人：Peglion Jean-Louis
公开号：US20090069296A1
公开（公告）日：2009-03-12
Compounds of formula (I):
wherein:
R
1
represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl,
R
2
, R
3
, R
4
and R
5
each represent a hydrogen atom or a hydroxy, methyl, —OSO
2
R
10
, —OCOR
10
or optionally substituted alkoxy group, or R
2
and R
3
, or R
3
and R
4
, or R
4
and R
5
together form a group —O—(CH
2
)
q
—O—, —O—CH═CH—O— or —O—CH═CH—,
R
6
, R
7
, R
8
and R
9
each represent a hydrogen atom or an alkoxy group, or R
6
and R
7
, or R
7
and R
8
, or R
8
and R
9
together form a group —O—(CH
2
)
q
—O—-,
R
10
represents a group selected from linear or branched C
1
-C
6
alkoxy, NR
11
R′
11
and optionally substituted alkyl,
R
11
and R′
11
each represent a hydrogen atom or an alkyl group, or R
11
and R′
1
together with the nitrogen atom carrying them form an optionally substituted, monocyclic or bicyclic, nitrogen-containing heterocycle,
X represents O, NH or CH
2
,
m and p each represent 0 or 1,
n and q each represent 1 or 2,
in racemic form or in the form of optical isomers,and also addition salts thereof with a pharmaceutically acceptable acid.
Medicinal products containing the same which are useful in treating various pathologies.
式（I）的化合物：
其中：
R1代表氢原子或从环烷基、苄基和可选择地取代的烷基中选择的基团，
R2、R3、R4和R5分别代表氢原子或羟基、甲基、—OSO2R10、—OCOR10或可选择地取代的烷氧基，或R2和R3，或R3和R4，或R4和R5一起形成一个基团—O—（
CH2）q—O—，—O—CH═CH—O—或—O—CH═CH—，
R6、R7、R8和R9分别代表氢原子或烷氧基，或R6和R7，或R7和R8，或R8和R9一起形成一个基团—O—（ ）q—O—-，
R10代表从线性或支链C1-C6烷氧基、NR11R′11和可选择地取代的烷基中选择的基团，
R11和R′11分别代表氢原子或烷基基团，或R11和R′1与携带它们的氮原子一起形成一个可选择地取代的、单环或双环、含氮杂环，
X代表O、NH或 ，
m和p各自代表0或1，
n和q各自代表1或2，
以外消旋形式或光学异构体形式，以及其与药学上可接受的酸的加合盐。
含有这些化合物的药物，对治疗各种病理有用。
