1,1,2,2-四乙氧基乙烷 | 3975-14-2

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1,2,2-四乙氧基乙烷
• 英文名称: 1,1,2,2-tetraethoxyethane
• 英文别名: tetraethyl ethane-1,1,2,2-tetracarboxylate；1,1,2,2-tetraethoxy-ethane；glyoxal bis-(diethyl acetal)；glyoxal-bis-diethylacetal；1,1,2,2-Tetraaethoxy-aethan；Glyoxal-bis-diaethylacetal
• CAS: 3975-14-2
• 化学式: C₁₀H₂₂O₄
• mdl: MFCD00043956
• 分子量: 206.282
• InChiKey: OKFWKSARFIIDBK-UHFFFAOYSA-N

物化性质

• 沸点：
  195-196 °C(Press: 753 Torr)
• 密度：
  0.938±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

SDS

Name:	1 1 2 2-Tetraethoxyethane 99+% Material Safety Data Sheet
Synonym:	None Known
CAS:	3975-14-2

Section 1 - Chemical Product MSDS Name:1 1 2 2-Tetraethoxyethane 99+% Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
3975-14-2	1,1,2,2-Tetraethoxyethane	99+%	223-606-9

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 3975-14-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: clear, colorless
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H22O4
Molecular Weight: 206.28

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 3975-14-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1,1,2,2-Tetraethoxyethane - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 3975-14-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 3975-14-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 3975-14-2 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1,1,2,2-四乙氧基乙烷 在 五氯化磷 作用下， 生成 1,2-二乙氧基-1,2-二氯乙烷
  参考文献：
  名称：

  Fiesselmann; Hoerndler, Chemische Berichte, 1954, vol. 87, p. 906,910

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-二氯-1,1-二乙氧基乙烷 在 sodium ethanolate 作用下， 生成 1,1,2,2-四乙氧基乙烷
  参考文献：
  名称：

  McElvain; Walters, Journal of the American Chemical Society, 1942, vol. 64, p. 1964

  摘要：

  DOI：

文献信息

• Preparation of diacetals of glyoxal
  申请人：——

  公开号：US20030069451A1

  公开（公告）日：2003-04-10

  A process is described for preparing diacetals of glyoxal by reacting from 40 to 75% by weight aqueous glyoxal with monohydric alcohols in the presence of an acid catalyst, which comprises leaving a liquid mixture which, at the beginning of the reaction, comprises alcohol and glyoxal in a molar ratio of at least 15:1 and also water in a concentration of not more than 8% by weight in contact with the acid catalyst until concentration in the reaction mixture of the diacetal formed reaches at least 70% of the equilibrium concentration without more than 5% by weight of the alcohol used having already been distilled off.

  描述了一种制备乙二醛二缩醛的过程，通过在酸催化剂存在下，将含有40至75%重量的水合乙二醛与一元醇反应，该过程包括将液体混合物在反应开始时，醇和乙二醛的摩尔比至少为15:1，同时水的浓度不超过8%重量，与酸催化剂接触，直到形成的二缩醛在反应混合物中的浓度达到至少达到平衡浓度的70%，而已蒸馏的醇不超过已使用醇的5%重量。
• Dissymetrisation de la molecule de glyoxal
  作者：A. Stambouli、R. Amouroux、F. Chastrette、M. Chastrette、G. Mattioda、A. Blanc

  DOI：10.1016/0022-328x(86)80467-3

  日期：1986.6

  Various organometallic compounds are treated with 1-acetoxy-1,2,2-triethoxyethane (1) an asymmetric derivative of glyoxal. Two kinds of reactions are observed depending on the nature of the organometallic reagents. Organolithium compounds give exclusively addition to the ester carbonyl group, while organocuprate derivatives lead to substitution of the acetoxy group. With Grignard reagents both reactions

  各种有机金属化合物用乙二醛的不对称衍生物1-乙酰氧基-1,2,2-三乙氧基乙烷（1）处理。根据有机金属试剂的性质，观察到两种反应。有机锂化合物仅加成酯羰基，而有机铜酸酯衍生物导致乙酰氧基的取代。使用格氏试剂，都会发生两个反应，加成和取代产物的比例取决于溶剂和烷基。讨论了路易斯酸的作用。
• Process for preparing styrene derivatives
  申请人：Saltigo GmbH

  公开号：US20130324745A1

  公开（公告）日：2013-12-05

  A process is provided which allows the synthesis of a large number of styrene derivatives with formation of C—C bonds, with use being possible of economically advantageous substrates, readily available carbon nucleophiles, and both inexpensive and environmentally unproblematic catalyst systems, permitting reaction under mild conditions and a high compatibility with functional groups on the reactants involved.

  提供了一种过程，允许合成大量苯乙烯衍生物，形成C—C键，可以使用经济优势的底物、易得的碳亲核试剂以及廉价且环境友好的催化系统，从而在温和条件下进行反应，并具有与参与反应的反应物上的功能基团高度兼容性。
• Glyoxal derivatives and method for making the same
  申请人：Loyola University of Chicago

  公开号：US05191127A1

  公开（公告）日：1993-03-02

  This invention provides glyoxal derivatives and a method for making these derivatives. A particularly useful derivative, 1-chloro-1,2,2-trialkoxyethane, and a facile method for making these alpha-halo ethers are provided. The alpha-halo ethers are valuable intermediates in the manufacture of a variety of commercial compounds.

  本发明提供了甘醛衍生物及其制备方法。特别有用的衍生物为1-氯-1,2,2-三烷氧基乙烷，提供了一种简便的制备这些α-卤基醚的方法。α-卤基醚是制造各种商业化合物的有价值的中间体。
• Process for continuously preparing acetals of alpha, beta-dicarbonyl compounds
  申请人：DEGUSSA AG

  公开号：US20040186304A1

  公开（公告）日：2004-09-23

  The present invention relates to a process for preparing acetals of &agr;,&bgr;-dicarbonyl compounds of the general formula (R″O) 2 CRCR′(OR″) 2 which are obtained by continuous reaction of &agr;,&bgr;-dicarbonyl compounds R—CO—CO—R′ with alcohols R″OH or HO—X—OH in countercurrent.

  本发明涉及一种制备一般式为(R″O)2CRCR′(OR″)2的α，β-二羰基化合物缩醛的方法，该方法通过将α，β-二羰基化合物R—CO—CO—R′与醇R″OH或HO—X—OH在逆流条件下进行连续反应而获得。