氢溴酸肼 | 13775-80-9

• 物质功能分类: 有机原料 - 肼或胲的有机衍生物
• 分子结构分类: 无机化合物 - 均质非金属化合物 - 卤代有机物
• 中文名称: 氢溴酸肼
• 中文别名: 肼-氢溴酸盐；单氢溴化肼；肼一氢溴酸；一氢溴酸联氨
• 英文名称: hydrazine monohydrobromide
• 英文别名: hydrazinium bromide；hydrazine hydrobromide；aminoazanium;bromide
• CAS: 13775-80-9
• 化学式: Br*H₅N₂
• 分子量: 112.957
• InChiKey: DVHXJLRODLTJOD-UHFFFAOYSA-N

物化性质

• 熔点：
  87-92 °C(lit.)
• 沸点：
  190°C
• 密度：
  2.300
• 闪点：
  190°C
• 溶解度：
  3260克/升可溶
• 稳定性/保质期：
  在常温常压下，该物质是稳定的。需避免与水分、潮湿和氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  3
• 氢受体数：
  2

ADMET

毒理性

• 副作用

Dermatotoxin - 皮肤烧伤。 Skin Sensitizer - 能够诱导皮肤过敏反应的剂。 Toxic Pneumonitis - 由于吸入金属烟雾或有毒气体和蒸气引起的肺部炎症。

Dermatotoxin - Skin burns. Skin Sensitizer - An agent that can induce an allergic reaction in the skin. Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• TSCA：
  Yes
• 危险等级：
  6.1
• 危险品标志：
  T
• 安全说明：
  S26,S27,S28,S36/37/39,S45,S53
• 危险类别码：
  R42/43,R45,R23/24/25,R34,R46
• WGK Germany：
  3
• 海关编码：
  2825 10 00
• 危险品运输编号：
  UN 3262 8/PG 2
• 包装等级：
  II
• 危险类别：
  6.1
• 储存条件：
  常温密闭保存，阴凉通风干燥。

SDS

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Section I.Chemical Product and Company Identification
Chemical Name Hydrazine Monohydrobromide
Portland OR
Synonym Hydrazine, hydrobromide (1:1) (CA INDEX NAME);
Hydrazinium Monobromide
H4N2•HBr
Chemical Formula
CAS Number 13775-80-9

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Section II. Composition and Information on Ingredients
Toxicology Data
Chemical Name CAS Number Percent (%) TLV/PEL
This chemical is classified as a Not available.
Hydrazine Monohydrobromide 13775-80-9 Min. 98.0 (T)
possible carcinogen. There is
no acceptable exposure limit for
a carcinogen.
This compound is classified as
a possible mutagen. There is
no acceptable exposure limit for
a mutagen.

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Section III. Hazards Identification
Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Acute Health Effects
Corrosive to skin, eyes, and respiratory system. Liquid or spray mist may produce tissue damage, particularly in mucous
membranes of the eyes, mouth and respiratory tract. Skin contact may produce burns. Eye contact can result in corneal
damage or blindness. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by
coughing, choking, or shortness of breath. Corrosive materials may cause serious injury if ingested.
Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
CARCINOGENIC EFFECTS : Not available.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local
skin destruction, or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung
damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in
one or many human organs.

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Section IV. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact
minutes. Get medical attention.
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
Skin Contact
and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
Inhalation If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
Ingestion DO NOT INDUCE VOMITING. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing,
perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible
indication that the toxic material was ingested; the absence of such signs, however, is not conclusive.
Continued on Next Page
Hydrazine Monohydrobromide

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Section V. Fire and Explosion Data
Not available.
Flammability May be combustible at high temperature. Auto-Ignition
Flammable Limits Not available.
Flash Points Not available.
Combustion Products These products include nitrogen oxides (NOx), halogenated compounds.
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.

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Section VI. Accidental Release Measures
Toxic material. Corrosive material. This material is a skin sensitizer. Possibly carcinogenic material. Possibly mutagenic
Spill Cleanup
material. Hygroscopic material. Heat and shock sensitive material. Light sensitive material.
Instructions
Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all sources of ignition. Consult
federal, state, and/or local authorities for assistance on disposal.

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Section VII. Handling and Storage
Handling and Storage TOXIC. CORROSIVE. SENSITIZER. POSSIBLE CARCINOGEN. POSSIBLE MUTAGEN. HYGROSCOPIC. HEAT AND
SHOCK SENSITIVE. LIGHT SENSITIVE. Keep locked up.. Keep container dry. Keep away from heat. Mechanical exhaust
Information
required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. DO NOT
ingest. Do not breathe dust. Never add water to this product. Wear suitable protective clothing. If ingested, seek medical
advice immediately and show the container or the label. Treat symptomatically and supportively.
Always store away from incompatible compounds such as oxidizing agents, alkalis (bases), moisture.

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Section VIII. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Face shield. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid
Personal Protection
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
This chemical is classified as a possible carcinogen. There is no acceptable exposure limit for a carcinogen.
Exposure Limits
This compound is classified as a possible mutagen. There is no acceptable exposure limit for a mutagen.

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Section IX. Physical and Chemical Properties
Physical state @ 20°C Solid. (White crystalline powder.) Solubility Soluble in water.
Not available.
Specific Gravity
Molecular Weight 112.96 Partition Coefficient Not available.
Boiling Point Not available. Not applicable.
Vapor Pressure
Melting Point 88°C (190.4°F) Vapor Density Not available.
Not available. Not available.
Refractive Index Volatility
Critical Temperature Not available. Odor Not available.
Not available. Not available.
Viscosity Taste

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Section X. Stability and Reactivity Data
Stability

---

This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability Avoid excessive heat and light. Moisture sensitive. Hygroscopic; keep container tightly closed.
Incompatibilities Reactive with oxidizing agents, alkalis (bases), moisture.
Continued on Next Page
Hydrazine Monohydrobromide

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Section XI. Toxicological Information
RTECS Number Not available.
Eye Contact. Ingestion. Inhalation. Skin contact.
Routes of Exposure
Toxicity Data Not available.
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local
skin destruction, or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung
damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in
one or many human organs.
Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Acute Toxic Effects
Corrosive to skin, eyes, and respiratory system. Liquid or spray mist may produce tissue damage, particularly in mucous
membranes of the eyes, mouth and respiratory tract. Skin contact may produce burns. Eye contact can result in corneal
damage or blindness. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by
coughing, choking, or shortness of breath. Corrosive materials may cause serious injury if ingested.
Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

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Section XII. Ecological Information
Ecotoxicity Not available.
Not available.
Environmental Fate

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Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

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Section XIV. Transport Information
DOT CLASS 6.1: Toxic material.
DOT Classification
DOT CLASS 8: Corrosive material
PIN Number
Proper Shipping Name Toxic solid, corrosive, inorganic, n.o.s.
Packing Group (PG) II
DOT Pictograms

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Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.
(EPA)
WHMIS Classification CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
CLASS E: Corrosive solid.
(Canada)
On NDSL.
EINECS Number (EEC) 237-412-7
EEC Risk Statements R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.
R34- Causes burns.
R45- May cause cancer.
R46- May cause heritable genetic damage.
R47- May cause birth defects.
Japanese Regulatory Data ENCS No. 1-105; 1-374
Continued on Next Page

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生产方法： 将等摩尔的水合肼与氢溴酸反应，经过冷冻处理后，在乙醇中结晶，从而制得所需产物。

反应信息

• 作为反应物：
  描述：

  氢溴酸肼 、 diborane(6) 以 further solvent(s) 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Process for making boron compounds

  摘要：

  公开号：

  US03323877A1
• 作为产物：
  描述：

  hydrazonium dibromide 生成 氢溴酸肼
  参考文献：
  名称：

  Christensen, B. E.; Gilbert, C., Journal of the American Chemical Society, 1934, vol. 56, p. 1808

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-二甲氨基吡啶 在 氢溴酸肼 、 potassium tert-butylate 、 溴 、 sodium hydride 、 sodium carbonate 、 magnesium 、 1,2-二溴乙烷 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 生成 [5-(5-Amino-3-methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-dimethyl-amine
  参考文献：
  名称：

  Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

  摘要：

  We have previously shown that 3-phenylpyrazolo[1,5-a]pyrimidines exemplified by 8 were potent antagonists of the human corticotropin-releasing factor-1 receptor. A series of 3-pyridylpyrazolo[1,5-a]pyrimidines 15, 25-30, 34, and 35 containing a weakly basic pyridine ring at the 3-position of the bicyclic nucleus was designed to reduce lipophilicity from the initial leads such as 7. Here, we showed that these 3-pyridyl compounds exhibited potent antagonists at the human CRF1, receptor. Moreover, the hydrophilic and weakly basic pyridine moiety increased the water solubility of some analogues. Compound 26h exhibited good binding affinity at the human CRF1 receptor with a K-i value of 3.5 nM. As a functional antagonist, it dose-dependently inhibited CRF-stimulated cAMP production in cells expressing the CRF1 receptor [IC50 = 50 nM), and CRF-stimulated ACTH release from cultured rat pituitary cells [IC50 = 20 nM). 26h had a log P value of 4.9 and water solubility of greater than 10 mg/mL. Pharmacokinetic studies in rats showed that 26h was orally bioavailable and able to penetrate into the brain. 26h has been demonstrated in vivo efficacy in animal behavioral models that measure anxiolytic activity. These results suggest that analogues from this series were potent CRF1, receptor antagonists with proper physicochemical properties and good pharmacokinetic profiles. 26h was developed into a clinical compound and exhibited efficacy in patients with major depression.

  DOI：

  10.1021/jm040058e

文献信息

• Excited-State Distortions Determined from Structured Luminescence of Nitridorhenium(V) Complexes
  作者：Susan E. Bailey、Rebecca A. Eikey、Mahdi M. Abu-Omar、Jeffrey I. Zink

  DOI：10.1021/ic010680m

  日期：2002.4.1

  The nitridorhenium(V) complexes ReNCl(2)(PCy3)(2) (1), ReNBr(2)(PCy3)(2) (2), ReNCl(2)(PPh3)(2) (3), and ReNBr(2)(PPh3)(2) (4) produce structured emission spectra upon excitation at low temperature. The origin, E(00), occurs at 15 775, 16 375, 15 875, and 16 300 cm(-1), respectively. The vibronic peaks are regularly spaced with an average energy separation corresponding to the Re triple bond N stretching

  氮化or（V）络合物ReNCl（2）（PCy3）（2）（1），ReNBr（2）（PCy3）（2）（2），ReNCl（2）（PPh3）（2）（3）和ReNBr （2）（PPh3）（2）（4）在低温激发时产生结构发射光谱。原点E（00）分别出现在15775、16375、15875和16300 cm（-1）处。振动子峰以与Re三键N拉伸频率相对应的平均能量间隔规则地间隔开。通过拉曼光谱和红外光谱测定，氮化or的拉伸频率范围为1095至1101 cm（-1）。通过拟合发射光谱来计算激发态畸变。激发态主要来自ad（xy）（ReN非键）到d（yz）（ReN pi反键）的跃迁。激发态的-氮键长度比基态电子态的长0.08 A，
• closo-Dodecaborate (B12H12)2− salts with nitrogen based cations and their energetic properties
  作者：Muddamarri Hanumantha Rao、Krishnamurthi Muralidharan

  DOI：10.1016/j.poly.2016.03.062

  日期：2016.9

  characterization and energetic properties of closo-dodecaborate salts with nitrogen based cations. The salts were produced in good yields by metathesis reactions of Ag2(B12H12) in deionized water, with simple filtration of the reaction mixture yielding the pure products. Thermogravimetric analyses established the thermal stabilities of these compounds. The enthalpies of combustion of these salts were determined

  摘要本文描述了含氮阳离子的十二-十二碳杂酸盐的合成，表征和能量性质。通过在去离子水中进行Ag2（B12H12）的复分解反应，可以简单地过滤反应混合物，得到纯净的产物，从而以高收率生产出这些盐。热重分析确定了这些化合物的热稳定性。这些盐的燃烧焓是用恒定体积的炸弹量热计确定的；从这些值计算出每千克炸药的形成焓和放出的热量。整个研究表明，这些富含硼和氮的盐具有在高能材料科学和技术中找到应用的潜力。
• Hydroxynaphthalenedicarboxylic acid hydrazide and derivatives thereof as well as process for preparing them
  申请人：Wakamori Hiroyuki

  公开号：US20060231589A1

  公开（公告）日：2006-10-19

  The present invention provides a hydroxynaphthalenedicarboxylic acid hydrazide or a derivative thereof represented by formula (1): wherein X 1 is a group selected from the group consisting of carboxyl group, a group represented by formula (2) and a group represented by formula (3): —CO—NH-Z  (2) —CO—NHNH 2 (3) Y 1 is a group selected from the group consisting of carboxyl group, carbamoyl group, a group represented by formula (2), a group represented by formula (3) and a group represented by formula (4): —CO—O-A  (4) provided that at least one of X 1 and Y 1 is a group represented by formula (3).

  本发明提供了一种由式（1）表示的羟基萘二甲酸肼或其衍生物：其中X1是从羧基，由式（2）表示的基团和由式（3）表示的基团组成的群中选择的基团：—CO—NH-Z  （2）—CO—NHNH2（3）Y1是从羧基，氨基甲酰基基团，由式（2）表示的基团，由式（3）表示的基团和由式（4）表示的基团组成的群中选择的基团：—CO—O-A  （4）只要X1和Y1中至少有一个是由式（3）表示的基团。
• Hydroxynaphthalenedicarboxylic acid hydrazide dimer and derivatives thereof as well as process for preparing them
  申请人：Wakamori Hiroyuki

  公开号：US20060235244A1

  公开（公告）日：2006-10-19

  The present invention provides a hydroxynaphthalenedicarboxylic acid hydrazide dimer or a derivative thereof represented by formula (1): wherein X 1 and X 2 are independently selected from the group consisting of carboxyl group, a group represented by formula (2) and a group represented by formula (3): —CO—NH-Z   (2) —CO—NHNH 2 (3) Y 1 and Y 2 are independently selected from the group consisting of carboxyl group, carbamoyl group, a group represented by formula (2), a group represented by formula (3) and a group represented by formula (4): —CO—O-A   (4) provided that at least one of X 1 , X 2 , Y 1 and Y 2 is a group represented by formula (3).

  本发明提供了一种由式（1）表示的羟基萘二羧酸肼二聚物或其衍生物：其中X1和X2分别独立地选自羧基，由式（2）表示的基团和由式（3）表示的基团组成的群；—CO—NH-Z  （2）—CO—NHNH2（3）Y1和Y2分别独立地选自羧基，氨基甲酰基，由式（2）表示的基团，由式（3）表示的基团和由式（4）表示的基团组成的群；—CO—O-A  （4）前提是X1、X2、Y1和Y2中至少有一个是由式（3）表示的基团。
• HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK
  申请人：McCall John M.

  公开号：US20120277224A1

  公开（公告）日：2012-11-01

  Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

  本文介绍了新的杂环化合物和组合物，以及它们作为治疗疾病的药物的应用。还提供了抑制人类或动物主体中PAS激酶（PASK）活性的方法，用于治疗糖尿病等疾病。

表征谱图