Approximately half amount of pyrazon /fed/ ... to rabbits was excreted ... /as/ unchanged chemical and ... 2-(p-hydroxyphenyl) analog. ... Similar results were obtained with cats and dogs although ... more p-hydroxy metabolite was excreted than unchanged pyrazon. Studies with pyrazon indicated that 5-amino-4-chloro-3-oxo-(2H)-pyridazine was formed after application to beets. A second metabolite was also detected ... but was not identified.
/Pyrazon/ ... /In rats/ A total of 10 fractions (nine metabolites and one isomer) in the urine and 5 fractions in the feces were noted. The major urinary metabolites were sulfate and glucuronide conjugates and the major fecal metabolite was a p-hydroxy derivative of Pyrazon. The sulfate and glucuronide conjugates and p-hydroxy derivative of pyrazon were recognized as the biliary metabolites ...
A photochemically controlled process was involved in the degradation of pyrazon in the leaves of beets. No degradation occurs in the dark. In sugar beets and red beets, pyrazon formed N-glucosylpyrazone. In addition 5-amino-4-chloro-3(2H)-pyridazinone and a strongly hydrophilic compound were formed.
Pyrazon [5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone], also known as chloridazon, is an herbicide belonging to the pyridazinone class of pesticides. It works as an herbicide by blocking electron transport in photosystem II in green plants, thereby inhibiting photosynthesis. Pyrazon is registered for pre-plant, pre-emergence, and early post-emergence use on sugar beets and red table beets to control certain weeds. Approximately 10% of the U.S. sugar beet crop and 50% of the U.S. table beet crop are treated with pyrazon annually. Pyrazon is also registered for commercial use on ornamentals, including bulb crops and roses. The available toxicity data on pyrazon are adequate to assess the chemical's hazard potential. Pyrazon is an herbicide considered to be of low toxicity without highly specific responses in mammals. Technical pyrazon has low (category III/IV) acute toxicity via the oral, dermal, and inhalation routes of exposure. It is not an eye or skin irritant (category IV) and does not cause dermal sensitization. In longer-term studies, reduced body weight associated with reduced food consumption appears to be the most significant effect of pyrazon exposure in laboratory animals. At higher doses, conditions such as poor general appearance and some motor effects considered to be associated with poor nutrition are noted in rats. In dogs, renal distal tubule vacuolation results at higher doses. No systemic effects resulted from dermal exposure to pyrazon. In both the rat and rabbit prenatal developmental studies, pyrazon did not demonstrate any effects on the fetuses to indicate increased susceptibility. There were no effects on the reproductive performance of rats. Based on the lack of pre- and/or postnatal susceptibility resulting following exposure to pyrazon, and considering the lack of residual uncertainties for pre- and/or postnatal toxicity, no special FQPA safety factor is needed. Therefore, the special FQPA safety factor was reduced to 1X. No neurobehavioral alterations or evidence of neuropathological effects were observed in the available rat and rabbit prenatal developmental toxicity studies or the rat multi-generation reproduction study. In addition, pyrazon is not considered to be neurotoxic from other guideline studies or in open literature reports. Some clinical signs suggesting neurotoxicity were noted at very high doses in the rat, but these were attributed to the weight loss and general poor condition of the rats. Based on the weight of evidence, a developmental neurotoxicity (DNT) study is not required for pyrazon. Pyrazon may be classified as "not likely to be a carcinogen in humans" based on the lack of evidence of carcinogenicity in the rat and mouse carcinogenicity studies.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌物分类
对人类无致癌性（未列入国际癌症研究机构IARC清单）。
No indication of carcinogenicity to humans (not listed by IARC).
来源:Toxin and Toxin Target Database (T3DB)
毒理性
副作用
职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
毒理性
毒性数据
LC50 (大鼠) > 30,800 毫克/立方米/4小时
LC50 (rat) > 30,800 mg/m3/4h
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
In the presence of 10 mmol sodium thiocyanate and 0.1 mole sodium nitrite at pH 1 (similar to stomach conditions), 10 mmol pyrazon reacts to n-methyl-nitroso-aniline. When mutagenicity was tested using Escherichia coli K-12 (343/113) in an in vitro system, pyrazon was not mutagenic. The derivatives induced mutations in the presence of metabolically active liver microsomes.
The toxicokinetic data indicate that pyrazon is readily absorbed by the rat gastrointestinal tract. The major excretory route is via the urine with most being excreted in 24 hours for low doses and 48 hours for higher doses. Biliary excretion is significant but a minor route. Females may excrete Pyrazon at lower rates than males based on the 14 day repeat dose study. Tissue burden is low with up to only 3.28% remaining ... Parent compound was detected only in small amounts in the urine and feces. Minor quantitative differences related to gender were identified.
Approximately half amount of pyrazon /fed/ ... to rabbits was excreted in urine within 24 hr ... Urinary excretion products resulting from oral administration of technical pyrazon /to rabbits/ included...unchanged pyrazon and p-hydroxy metabolite ... also isopyrazon, present in technical formulation as impurity, and its p-hydroxy metabolites. Similar results were obtained with cats and dogs ...
Foliar absorption occurs but is not of major importance to herbicidal action. Translocation from treated leaves is limited. ... Root absorption is rapid and subsequent translocation to all plant parts suggests xylem transport.
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
在藜（Chenopodium album L）中，吡唑隆在叶片中积累，但被根部代谢。
In lambsquarters, (Chenopodium album L), pyrazon was accumulate in the leaves but metabolized by roots.
[EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
申请人：GILEAD APOLLO LLC
公开号：WO2017075056A1
公开（公告）日：2017-05-04
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
[EN] 3-[(HYDRAZONO)METHYL]-N-(TETRAZOL-5-YL)-BENZAMIDE AND 3-[(HYDRAZONO)METHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE DERIVATIVES AS HERBICIDES<br/>[FR] DÉRIVÉS DE 3-[(HYDRAZONO))MÉTHYL]-N-(TÉTRAZOL-5-YL)-BENZAMIDE ET DE 3-[(HYDRAZONO)MÉTHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE UTILISÉS EN TANT QU'HERBICIDES
申请人：SYNGENTA CROP PROTECTION AG
公开号：WO2021013969A1
公开（公告）日：2021-01-28
The present invention related to compounds of Formula (I): or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4, R5 and R6 are as described herein. The invention further relates to compositions comprising said compounds, to methods of controlling weeds using said compositions, and to the use of compounds of Formula (I) as a herbicide.
[EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
申请人：SYNGENTA PARTICIPATIONS AG
公开号：WO2013079350A1
公开（公告）日：2013-06-06
Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.
式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
TRIAZOLE ACC INHIBITORS AND USES THEREOF
申请人：Gilead Apollo, LLC
公开号：US20170166584A1
公开（公告）日：2017-06-15
The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
本发明提供了三唑化合物，可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及其组合物和使用方法。
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
申请人：Dow AgroSciences LLC
公开号：US20180279612A1
公开（公告）日：2018-10-04
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
