2-羟基-2-甲基丙酸铵 | 2539-76-6

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-羟基-2-甲基丙酸铵
• 英文名称: ammonium 2-hydroxy-2-methylpropanoate
• 英文别名: Azane;2-hydroxy-2-methylpropanoic acid
• CAS: 2539-76-6
• 化学式: C₄H₇O₃*H₄N
• 分子量: 121.136
• InChiKey: KCIBQYJUQYVPAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.12
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2923900090

反应信息

• 作为反应物：
  描述：

  2-羟基-2-甲基丙酸铵 以 水 、 4-甲基-2-戊酮 为溶剂， 生成 2-甲基-2-羟基丙酸
  参考文献：
  名称：

  Reactive Extraction of Free Organic Acids from the Ammonium Salts Thereof

  摘要：

  该发明涉及一种将有机酸铵盐转化为特定游离有机酸的过程，其中将铵盐的水溶液与有机萃取剂接触，并在水溶液和萃取剂处于液态的温度和压力下解离盐，并引入脱氨介质或夹带气体，以从水溶液中去除NH3并将形成的至少一部分游离有机酸转移到有机萃取剂中。该发明描述了一种改进的释放有机酸的过程，尤其是从铵盐中释放和去除氨并同时用适当的萃取剂从水相中萃取释放的酸，优选为羧酸、磺酸或膦酸，特别是α-羟基羧酸或β-羟基羧酸。这个过程对应于反应性萃取。通过使用脱氨介质或夹带气体（例如氮气、空气、蒸汽或惰性气体，例如氩气），可以显著改善从水溶液中的有机酸铵盐溶液中反应性萃取有机酸的过程。释放的氨由连续气流从水溶液中去除，并可以回馈到生产过程中。游离酸可以通过蒸馏、精馏、结晶、再萃取、色谱、吸附或膜过程等过程从萃取剂中获得。

  公开号：

  US20100210871A1
• 作为产物：
  描述：

  2-甲基-2-羟基丙酸 在 氨 作用下， 以 水 为溶剂， 生成 2-羟基-2-甲基丙酸铵
  参考文献：
  名称：

  Reactive Extraction of Free Organic Acids from the Ammonium Salts Thereof

  摘要：

  该发明涉及一种将有机酸铵盐转化为特定游离有机酸的过程，其中将铵盐的水溶液与有机萃取剂接触，并在水溶液和萃取剂处于液态的温度和压力下解离盐，并引入脱氨介质或夹带气体，以从水溶液中去除NH3并将形成的至少一部分游离有机酸转移到有机萃取剂中。该发明描述了一种改进的释放有机酸的过程，尤其是从铵盐中释放和去除氨并同时用适当的萃取剂从水相中萃取释放的酸，优选为羧酸、磺酸或膦酸，特别是α-羟基羧酸或β-羟基羧酸。这个过程对应于反应性萃取。通过使用脱氨介质或夹带气体（例如氮气、空气、蒸汽或惰性气体，例如氩气），可以显著改善从水溶液中的有机酸铵盐溶液中反应性萃取有机酸的过程。释放的氨由连续气流从水溶液中去除，并可以回馈到生产过程中。游离酸可以通过蒸馏、精馏、结晶、再萃取、色谱、吸附或膜过程等过程从萃取剂中获得。

  公开号：

  US20100210871A1

文献信息

• THERMAL SALT SPLITTING OF AMMONIUM CARBOXYLATES
  申请人：Haas Thomas

  公开号：US20110118504A1

  公开（公告）日：2011-05-19

  The present invention relates to a process for preparing hydroxycarboxylic acids, preferably α- and β-hydroxycarboxylic acids, from ammonium carboxylates of the general formula in which R 1 , R 2 and R 3 are each independently H, OH, (C 1 -C 6 )-alkyl optionally substituted by a hydroxyl group, (C 1 -C 6 )-alkenyl optionally substituted by a hydroxyl group, (C 1 -C 6 )-alkoxy optionally substituted by a hydroxyl group, (C 1 -C 6 ) -alkylthio-(C 1 -C 6 )-alkyl optionally substituted by a hydroxyl group, (C 6 -C 10 )-aryl optionally substituted by a hydroxyl group, (C 7 -C 12 )-aralkyl optionally substituted by a hydroxyl group, (C 3 -C 5 )-heteroaryl optionally substituted by a hydroxyl group, with the proviso that at least one hydroxyl group is present in at least one R 1 , R 2 and R 3 radical, preferably R 1 ═H, CH 3 , CH 2 CH 3 , C 6 H 5 , (CH 2 ) 2 SCH 3 and R 2 ═H, CH 3 and R 3 ═OH, equally preferably R 1 ═CH 2 OH, CHOHCH 3 and R 2 ═R 3 ═H, CH 3 , more preferably R 1 ═R 2 ═CH 3 and R 3 ═OH, equally more preferably R 1 ═CH 2 OH, R 2 ═CH 3 and R 3 ═H, comprising the following step: heating an aqueous starting solution comprising the ammonium carboxylate to form, by thermal decomposition of the ammonium carboxylate, the hydroxycarboxylic acid and ammonia, and simultaneously to remove at least a portion of the free water and of the ammonia formed from the solution and thus to obtain a product fraction comprising the hydroxycarboxylic acid, characterized in that the content of the ammonium salt in the starting solution is less than 60% by weight, the thermal decomposition of the ammonium salt and the removal of the free water and of the ammonia formed are effected in one process step, the conversion of the ammonium salt being more than 20 mol %, preferably more than 30 mol %, more preferably more than 50 mol %, especially preferably more than 75 mol %, very especially preferably more than 90 mol % and especially more than 95 mol %, and no ether, alcohol or hydrocarbon is used as an entraining agent.

  本发明涉及一种从一般式的铵羧酸盐制备羟基羧酸，优选为α-和β-羟基羧酸的过程，其中该一般式中，R1、R2和R3各自独立地为H、OH、(C1-C6)烷基，该烷基可选地被羟基取代，(C1-C6)烯基，该烯基可选地被羟基取代，(C1-C6)烷氧基，该烷氧基可选地被羟基取代，(C1-C6)烷硫基-(C1-C6)烷基，该烷基可选地被羟基取代，(C6-C10)芳基，该芳基可选地被羟基取代，(C7-C12)芳基烷基，该芳基烷基可选地被羟基取代，(C3-C5)杂环芳基，该杂环芳基可选地被羟基取代，但至少在R1、R2和R3中的一个基团中存在一个羟基，优选为R1═H、CH3、CH2CH3、C6H5、(CH2)2SCH3和R2═H、CH3以及R3═OH，同样优选为R1═CH2OH、CHOHCH3且R2═R3═H、CH3，更优选为R1═R2═CH3且R3═OH，同样更优选为R1═CH2OH、R2═CH3且R3═H。该过程包括以下步骤：加热含铵羧酸盐的水溶液，通过铵羧酸盐的热分解形成羟基羧酸和氨，并同时从溶液中去除至少一部分游离水和形成的氨，从而得到包含羟基羧酸的产品组分。其特点在于，起始溶液中铵盐的含量小于60%重量，铵盐的热分解和游离水和形成的氨的去除在一个过程步骤中完成，铵盐的转化率大于20摩尔％，优选大于30摩尔％，更优选大于50摩尔％，特别优选大于75摩尔％，非常特别优选大于90摩尔％，尤其是大于95摩尔％，且不使用醚、醇或烃作为夹带剂。
• Harnung, S. E.; Larsen, E.; Pedersen, E. J., Acta Chemica Scandinavica, 1993, vol. 47, # 7, p. 674 - 682
  作者：Harnung, S. E.、Larsen, E.、Pedersen, E. J.

  DOI：——

  日期：——
• Salov, V. N.; Zil'berman, E. N.; Starkov, A. A., Journal of applied chemistry of the USSR, 1982, vol. 55, # 7, p. 1487 - 1490
  作者：Salov, V. N.、Zil'berman, E. N.、Starkov, A. A.

  DOI：——

  日期：——
• Reactive Extraction of Free Organic Acids from the Ammonium Salts Thereof
  申请人：Kobler Christoph

  公开号：US20100210871A1

  公开（公告）日：2010-08-19

  The invention relates to a process for converting ammonium salts of organic acids to the particular free organic acid, wherein an aqueous solution of the ammonium salt is contacted with an organic extractant and the salt is dissociated at temperatures and pressures at which the aqueous solution and the extractant are in the liquid state, and a stripping medium or entraining gas is introduced in order to remove NH 3 from the aqueous solution and transfer at least a portion of the free organic acid formed to the organic extractant. The invention described here thus provides an improved process for releasing an organic acid, preferably a carboxylic, sulphonic or phosphonic acid, especially an alpha-hydroxycarboxylic acid or beta-hydroxycarboxylic acid, from the ammonium salt thereof by release and removal of ammonia and simultaneous extraction of the acid released with a suitable extractant from the aqueous phase. This process corresponds to a reactive extraction. The reactive extraction of an organic acid from the aqueous ammonium salt solution thereof can be improved significantly by the use of a stripping medium or entraining gas, for example nitrogen, air, steam or inert gases, for example argon. The ammonia released is removed from the aqueous solution by the continuous gas stream and can be fed back into a production process. The free acid can be obtained from the extractant by a process such as distillation, rectification, crystallization, re-extraction, chromatography, adsorption, or by a membrane process.

  该发明涉及一种将有机酸铵盐转化为特定游离有机酸的过程，其中将铵盐的水溶液与有机萃取剂接触，并在水溶液和萃取剂处于液态的温度和压力下解离盐，并引入脱氨介质或夹带气体，以从水溶液中去除NH3并将形成的至少一部分游离有机酸转移到有机萃取剂中。该发明描述了一种改进的释放有机酸的过程，尤其是从铵盐中释放和去除氨并同时用适当的萃取剂从水相中萃取释放的酸，优选为羧酸、磺酸或膦酸，特别是α-羟基羧酸或β-羟基羧酸。这个过程对应于反应性萃取。通过使用脱氨介质或夹带气体（例如氮气、空气、蒸汽或惰性气体，例如氩气），可以显著改善从水溶液中的有机酸铵盐溶液中反应性萃取有机酸的过程。释放的氨由连续气流从水溶液中去除，并可以回馈到生产过程中。游离酸可以通过蒸馏、精馏、结晶、再萃取、色谱、吸附或膜过程等过程从萃取剂中获得。