申请人:——
公开号:US20040138301A1
公开(公告)日:2004-07-15
This invention relates to chemical uncouplers with a broader safety window making the use of them in treating obesity and, consequently, in the treatment of obesity related diseases and conditions such as atherosclerosis, hypertension, diabetes, especially type 2 diabetes (NIDDM (non-insulin dependent diabetes mellitus)), impaired glucose tolerance, dyslipidemia, coronary heart disease, gallbladder disease, osteoarthritis and various types of cancer such as endometrial, breast, prostate and colon cancers and the risk for premature death as well as other conditions, such as diseases and disorders, which conditions are improved by an increase in mitochondrial respiration, more attractive.
这项发明涉及一种化学解偶联剂,它具有更宽的安全窗口,使其在治疗肥胖症以及因此引发的相关疾病和状况,如动脉硬化、高血压、糖尿病(尤其是2型糖尿病(非胰岛素依赖型糖尿病))、葡萄糖耐量受损、血脂异常、冠心病、胆结石病、骨关节炎以及子宫内膜、乳房、前列腺和结肠等各种癌症以及过早死亡的风险等方面更具吸引力。此外,还包括其他通过增加线粒体呼吸得到改善的条件、疾病和紊乱。