靛红-5-磺酸钠 | 80789-74-8

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 靛红-5-磺酸钠
• CAS: 80789-74-8
• 化学式: C8H5NNaO5S
• 分子量: 250.19
• InChiKey: UTPGIWQYDDBRPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.31
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090

文献信息

• Pharmaceutically active sulfanilide derivatives
  申请人：——

  公开号：US20040072816A1

  公开（公告）日：2004-04-15

  The present invention relates to sulfanilide derivatives of formula (I), in which R 1 and R 2 are optionally substituted aryl and heteroaryl groups and the other variables are as defined in the claims, for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such sulfanilide derivatives. Said derivatives are useful in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. In particular, the present invention is related to sulfanilide derivatives displaying a substantial modulatory, in particular antagonistic activity, of the oxytocin and/or vasopressin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin and/or vasopressin, including preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. The present invention is furthermore related to novel sulfanilide derivatives as well as to methods of their preparation.

  本发明涉及式(I)的磺胺基苯酰胺衍生物，其中R1和R2是可选择取代的芳基和杂环芳基基团，其他变量如权利要求中所定义，用作药用活性化合物，以及含有这种磺胺基苯酰胺衍生物的药物配方。所述衍生物在治疗和/或预防早产、早产、痛经、抗利尿素分泌不当、充血性心力衰竭、动脉高血压、肝硬化、肾病综合征和眼压增高方面具有用途。具体而言，本发明涉及显示对催产素和/或抗利尿素受体具有显著调节作用，特别是拮抗活性的磺胺基苯酰胺衍生物。更具体地说，所述化合物在治疗和/或预防由催产素和/或抗利尿素介导的疾病状态方面具有用途，包括早产、早产、痛经、抗利尿素分泌不当、充血性心力衰竭、动脉高血压、肝硬化、肾病综合征和眼压增高。本发明还涉及新型磺胺基苯酰胺衍生物以及其制备方法。
• [EN] THIOSEMICARBAZONES WITH MDR1 - INVERSE ACTIVITY<br/>[FR] THIOSEMICARBAZONES À ACTIVITÉ ANTI-MDR1
  申请人：US HEALTH

  公开号：WO2012033601A1

  公开（公告）日：2012-03-15

  Disclosed herein are drug compounds that have MDR-inverse activity and thus are effective against multidrug-resistant cells. Exemplary compounds disclosed herein have the structure;Formula (I). Examples of the disclosed compounds have been found to have, inter alia, efficacy in directly treating multidrug resistant cells, rendering multidrug resistant cells susceptible to other chemotherapeutics and in some instances reversing multidrug resistance.

  本文披露了具有MDR逆转活性的药物化合物，因此对多药耐药细胞有效。本文披露的示例化合物具有下列结构；公式（I）。已发现披露的化合物的示例具有直接治疗多药耐药细胞的功效，使多药耐药细胞对其他化疗药物敏感，并在某些情况下逆转多药耐药。
• [EN] BLACK PIGMENT DISPERSION<br/>[FR] DISPERSION DE PIGMENT NOIR
  申请人：BASF SE

  公开号：WO2010081756A1

  公开（公告）日：2010-07-22

  Described is a pigment dispersion which is useful for electrophoretic displays comprising α) a bis-oxodihydro-indolylene-benzodifuranone colourant of the Formula (I) wherein the substituents are defined as in claim 1, β) a specific polymeric dispersant, and γ) a solvent which is suitable for dispersions used in electrophoretic displays. Also described are novel colourants and dispersants.

  描述了一种用于电泳显示的颜料分散剂，包括α）公式（I）中的双氧二氢吲哚基苯并二呋喃酮颜料，其中取代基的定义如权利要求1所述，β）特定的聚合物分散剂，和γ）适用于电泳显示中使用的分散剂的溶剂。还描述了新颖的颜料和分散剂。
• [EN] PHARMACEUTICALLY ACTIVE SULFANILIDE DERIVATIVES<br/>[FR] DERIVES DE SULFANILIDE ACTIFS DU POINT DE VUE PHARMACEUTIQUE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2002032864A1

  公开（公告）日：2002-04-25

  The present invention relates to sulfanilide derivatives of formula (I), in which R?1 and R2¿ are optionally substituted aryl and heteroaryl groups and the other variables are as defined in the claims, for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such sulfanilide derivatives. Said derivatives are useful in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. In particular, the present invention is related to sulfanilide derivatives displaying a substantial modulatory, in particular antagonistic activity, of the oxytocin and/or vasopressin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin and/or vasopressin, including preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. The present invention is furthermore related to novel sulfanilide derivatives as well as to methods of their preparation.

  本发明涉及公式（I）的磺胺基苯酰亚胺衍生物，其中R1和R2是可选取代的芳基和杂环芳基基团，其他变量如权利要求所定义，用作药物活性化合物，以及含有这种磺胺基苯酰亚胺衍生物的药物配方。所述衍生物在治疗和/或预防早产、早产、痛经、抗利尿激素不当分泌、充血性心力衰竭、动脉高血压、肝硬化、肾病综合征和眼压增高方面有用。特别是，本发明涉及显示 oxytocin 和/或 vasopressin 受体的实质性调节活性，特别是拮抗活性的磺胺基苯酰亚胺衍生物。更好地，这些化合物在治疗和/或预防由 oxytocin 和/或 vasopressin 介导的疾病状态方面有用，包括早产、早产、痛经、抗利尿激素不当分泌、充血性心力衰竭、动脉高血压、肝硬化、肾病综合征和眼压增高。本发明还涉及新的磺胺基苯酰亚胺衍生物以及它们的制备方法。
• Infra red absorbing compounds and their use in photoimageable elements
  申请人：——

  公开号：US20040180285A1

  公开（公告）日：2004-09-16

  Infrared absorbing compounds in which the anion is selected from the group consisting of 5-isatinsulfonate, 10-camphorsulfonate, and 4,5-dihydroxy-1,3-benzenedisulfonate are disclosed. Negative-working imageable elements containing these compounds have improved dot stability.

  本发明揭示了阴离子选自5-异吲哚磺酸盐、10-樟脑磺酸盐和4,5-二羟基-1,3-苯二磺酸盐等组成的红外吸收化合物。包含这些化合物的负向感光元件具有改善的点稳定性。