3-十二烷氧基丙胺 | 7617-74-5

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-十二烷氧基丙胺
• 中文别名: 3-月桂氧基丙胺；3-十二烷氧基丙胺(LOPA)；3-(十二烷氧基)丙氨；劳立沙明；十二烷氧基丙胺
• 英文名称: 3-(dodecyloxy)-1-propylamine
• 英文别名: 3-dodecyloxy-1-propanamine；3-lauryloxypropylamine；3-dodecyloxypropylamine；dodecyloxypropylamine；3-lauloxypropylamine；3-dodecyloxy-propylamine；Laurixamine；3-dodecoxypropan-1-amine
• CAS: 7617-74-5
• 化学式: C₁₅H₃₃NO
• mdl: MFCD00025621
• 分子量: 243.433
• InChiKey: ZRJOUVOXPWNFOF-UHFFFAOYSA-N

物化性质

• 熔点：
  13 °C
• 沸点：
  315 °C
• 密度：
  0.845
• 闪点：
  165 °C
• 稳定性/保质期：
  如果按照规格进行使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  17
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  8
• 危险品标志：
  C
• 安全说明：
  S26,S37/39,S45
• 危险类别码：
  R22,R34
• 危险品运输编号：
  2735
• 海关编码：
  2922199090
• 包装等级：
  II
• 危险类别：
  8

SDS

Name:	3-Lauryloxypropyl-1-amine 98% Material Safety Data Sheet
Synonym:	3-n-Dodecyloxy-1-aminopropane; 1-Propanamine, 3-(dodecyloxy)-; 3-Dodecyloxypropanamin
CAS:	7617-74-5

Section 1 - Chemical Product MSDS Name:3-Lauryloxypropyl-1-amine 98% Material Safety Data Sheet
Synonym:3-n-Dodecyloxy-1-aminopropane; 1-Propanamine, 3-(dodecyloxy)-; 3-Dodecyloxypropanamin

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7617-74-5	3-Lauryloxypropyl-1-amine	98	231-528-1

Hazard Symbols: C
Risk Phrases: 22 34

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed. Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause central nervous system depression. May cause systemic effects.
Inhalation:
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract. Exposure produces central nervous system depression. Aspiration may lead to pulmonary edema.
May cause systemic effects.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
This material is lighter than water and insoluble in water. The fire could easily be spread by the use of water in an area where the water cannot be contained. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes.
Storage:
Store in a tightly closed container. Corrosives area. Store in a cool, dry area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7617-74-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Clear liquid
Color: clear, colorless
Odor: None reported.
pH: Not available.
Vapor Pressure: <1 mbar @ 20 C
Viscosity: 6.9 MPA 20.00 deg C
Boiling Point: 315 deg C @ 760.00mm Hg
Freezing/Melting Point: 13 deg C
Autoignition Temperature: 270 deg C ( 518.00 deg F)
Flash Point: 165 deg C ( 329.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: <0.1 g/l (20 c)
Specific Gravity/Density: .8450g/cm3
Molecular Formula: C15H33ON
Molecular Weight: 243.43

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat.
Incompatibilities with Other Materials:
No information found..
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7617-74-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
3-Lauryloxypropyl-1-amine - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE LIQUID, BASIC, ORGANIC, N.O.S*
Hazard Class: 8
UN Number: 3267
Packing Group: III
IMO
Shipping Name: CORROSIVE LIQUID, BASIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3267
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE LIQUID, BASIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3267
Packing group: III

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 22 Harmful if swallowed.
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
WGK (Water Danger/Protection)
CAS# 7617-74-5: 2
Canada
CAS# 7617-74-5 is listed on Canada's NDSL List.
CAS# 7617-74-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7617-74-5 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-十二烷氧基丙胺 在 氯化亚砜 、 三乙胺 作用下， 以 氯仿 为溶剂， 以52%的产率得到5-t-butyl-4-chloromethyl-2-{4-(3-dodecyloxypropyl)carbamoyl-2-nitrophenyl}-4-isoxazolin-3-one
  参考文献：
  名称：

  2-aryl-4-halomethyl-4-isoxazolin-3-one derivatives

  摘要：

  公式（I）的2-芳基-4-卤甲基-4-异噁唑啉-3-1衍生物，可作为银卤化物感光材料中阳性工作化合物的中间体。其中，R.sup.1代表取代或未取代的含有1至6个碳原子的烷基或含有6至24个碳原子的取代或未取代芳基；R.sup.2、R.sup.3和R.sup.4相同或不同，每个最多有20个碳原子，且每个代表氢、取代或未取代的烷氧基、取代或未取代的芳氧基、取代或未取代的酰基、取代或未取代的烷氧羰基、取代或未取代的芳氧羰基、卤素、硝基、取代或未取代的氨基甲酰基、取代或未取代的磺胺基、取代或未取代的磺酰基、氰基、三氟甲基或羧基，但R.sup.2和R.sup.3中至少一个为氰基、取代或未取代的磺酰基、三氟甲基或硝基；X代表氟、氯、溴或碘。

  公开号：

  US05071994A1
• 作为产物：
  描述：

  3-(十二烷氧基)丙腈 在 Raney type Ni-Mo-Al catalyst R-239 氢气 作用下， 以 水 为溶剂， 150.0 ℃ 、1.0 MPa 条件下， 生成 3-十二烷氧基丙胺
  参考文献：
  名称：

  Process for production of ether amine

  摘要：

  公开号：

  EP1219597B1

文献信息

• Xylene-diamines as antiviral agents
  申请人：Pfizer Inc.

  公开号：US04034040A1

  公开（公告）日：1977-07-05

  Compounds of the formula ##STR1## or a non-toxic acid addition salt thereof wherein R.sub.1 is alkyl of from 1 to 20 carbon atoms; R.sub.2 is alkyl of from 12 to 20 carbon atoms; R.sub.3 is selected from the group consisting of hydrogen and hydroxyalkyl of from 2 to 8 carbon atoms; and R.sub.4 is selected from the group consisting of hydrogen, alkyl of from 1 to 8 carbon atoms and hydroxyalkyl of from 2 to 8 carbon atoms, said compounds are useful for combating viral infections in vertebrate animals.

  式##STR1##的化合物或其非毒性酸盐，其中R.sub.1是由1至20个碳原子组成的烷基；R.sub.2是由12至20个碳原子组成的烷基；R.sub.3选自由2至8个碳原子的氢和羟基烷基组成的群；R.sub.4选自由1至8个碳原子的氢、烷基和由2至8个碳原子组成的羟基烷基，这些化合物对于对抗脊椎动物的病毒感染是有用的。
• Release sustaining composition and sustained release preparation
  申请人：Hayakawa Kazuhisa

  公开号：US20050147676A1

  公开（公告）日：2005-07-07

  A release sustaining composition comprising a polyalkylene polyol derivative comprising repeating units U-1 derived from a water-soluble polyalkylene polyol and a polyisocyanate and repeating units U-2 derived from a dihydroxy compound and a polyisocyanate in a molar ratio of U-1/U-2 between 0.5/0.5 and 0.99/0.01 and optionally a water-soluble cellulose ether is combined with an active ingredient to make a sustained release preparation.

  一种持续释放组合物，包括由可溶于水的聚烯烃聚醚和聚异氰酸酯衍生的重复单元U-1以及由二羟基化合物和聚异氰酸酯衍生的重复单元U-2，在U-1/U-2的摩尔比在0.5/0.5至0.99/0.01之间，可选地与可溶于水的纤维素醚结合，用于制备持续释放制剂。
• Über die Darstellung und Eigenschaften von α-Amino-phosphonigsäuren
  作者：N. Kreutzkamp、C. Schimpfky、K. Storck

  DOI：10.1002/ardp.19673001010

  日期：——

  Durch Umsetzung von unterphosphoriger Säure mit primären Aminen und Carbonylverbindungen oder durch Anlagerung der Säure an Azomethine wurden α‐Amino‐phosphonigsäuren dargestellt. Eigenschaften und Umwandlungsmöglichkeiten werden diskutiert.

  次磷酸与伯胺和羰基化合物反应，或将次磷酸加入偶氮甲碱，生成α-氨基-亚膦酸。讨论了属性和转换的可能性。
• N,N'-dialkyl derivatives of polyhydroxyalkyl alkylenediamines
  申请人：Ford Edward Michael

  公开号：US20060013780A1

  公开（公告）日：2006-01-19

  Surfactant compositions containing compounds according to structure (I), and methods of making them, are disclosed. The compounds provide reduced dynamic and equilibrium surface tension, good solubility, moderate foaming, and good cleaning performance. The methods for making them involve reaction of N-(polyhydroxyalkyl)-alkylamines with dinitriles, dialdehydes, or acetals or hemiacetals of dialdehydes in the presence of hydrogen and a transition metal catalyst. In structure (I), x is an integer from about 1 to 12, R 1 and R 2 are independently C3-C30 linear alkyl, cyclic alkyl, branched alkyl, alkenyl, aryl, alkylaryl, alkoxyalkyl, and dialkylaminoalkyl; and R 3 and R 4 are independently hydrogen or a pyranosyl group such as α-D-glucopyranosyl, β-D-glucopyranosyl, or β-D-galactopyranosyl.

  含有结构（I）中化合物的表面活性剂组合物以及制备它们的方法已被披露。这些化合物提供了降低的动态和平衡表面张力、良好的溶解性、适度的起泡性能和良好的清洁性能。制备它们的方法涉及N-(多羟基烷基)-烷基胺与二腈、二醛或二醛的缩醛或半缩醛在氢气和过渡金属催化剂存在下的反应。在结构（I）中，x是约1到12之间的整数，R1和R2独立地为C3-C30线性烷基、环烷基、支链烷基、烯烃、芳基、烷基芳基、烷氧基烷基和二烷基氨基烷基；R3和R4独立地为氢或吡喃基团，如α-D-葡萄糖吡喃基、β-D-葡萄糖吡喃基或β-D-半乳糖吡喃基。
• Processs for preparing triazine compounds
  申请人：Nagase Hisato

  公开号：US20060281919A1

  公开（公告）日：2006-12-14

  A process for preparing a triazine compound represented by formula (1) including reacting a 2,4,6-trichlorotriazine, in the presence of a base, with a compound represented by the formula (2) in an organic solvent containing water and an aromatic hydrocarbon is provided.

  本发明提供了一种制备由式（1）所表示的三嗪化合物的过程，包括在含水和芳香族碳氢化合物的有机溶剂中，在碱的存在下，将2,4,6-三氯三嗪与式（2）所表示的化合物反应。