番石榴酸 | 469-65-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 番石榴酸
• 英文名称: Piscidic acid
• 英文别名: 2,3-dihydroxy-2-[(4-hydroxyphenyl)methyl]butanedioic acid
• CAS: 469-65-8
• 化学式: C₁₁H₁₂O₇
• 分子量: 256.21
• InChiKey: TUODPMGCCJSJRH-UHFFFAOYSA-N

物化性质

• 沸点：
  359.45°C (rough estimate)
• 密度：
  1.4423 (rough estimate)
• LogP：
  -0.174 (est)
• 物理描述：
  Solid
• 熔点：
  186-187°C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  dimethyl (4R,5S)-2,2-dimethyl-4-[(4-phenylmethoxyphenyl)methyl]-1,3-dioxolane-4,5-dicarboxylate 、 溶剂黄146 、 盐酸 、 水 生成 番石榴酸
  参考文献：
  名称：

  NIE, XINYONG;WANG, QIAN;LI, YULIN;PAN, XINFU, CHEM. J. CHIN. UNIV., 8,(1987) N 7, 620-622

  摘要：

  DOI：

文献信息

• Bioavailability and improved delivery of alkaline pharmaceutical drugs
  申请人：——

  公开号：US20040214215A1

  公开（公告）日：2004-10-28

  Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an alkaline pharmaceutical drug and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.

  本发明实施例涉及一种组合物、制备该组合物的过程以及使用该组合物。该组合物包括碱性药物和至少一种选择自羟酸、多羟酸、相关酸、内酯或其组合物的分子复合物。该组合物提供了改善的生物利用度和将药物输送至皮肤组织的改善输送。
• Bioavailability and Improved Delivery of Alkaline Pharmaceutical Drugs
  申请人：Yu J. Ruey

  公开号：US20080032937A1

  公开（公告）日：2008-02-07

  Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an alkaline pharmaceutical drug and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.

  本发明实施例涉及一种组合物、制备该组合物的方法以及使用该组合物。该组合物包括碱性药物和至少选自羟酸、多羟基酸、相关酸、内酯或其组合物之一形成的分子复合物。该组合物提供了改善的生物利用度和将药物输送到皮肤组织中的改善途径。
• Urea composition
  申请人：——

  公开号：US20040033963A1

  公开（公告）日：2004-02-19

  The invention is directed to compositions, methods of making the compositions, and methods of treating cosmetic and dermatological disorders with a composition that includes a molecular complex between urea and a functional substance that has at least one hydroxyl group and one carboxyl group either as a free acid, a salt, an amide or a lactone. The compositions are stable when compared to conventional urea-containing compositions, and provide controlled-release of the urea.

  本发明涉及组合物、组合物的制造方法以及用组合物治疗化妆品和皮肤病的方法，该组合物包括尿素与一种功能物质之间的分子络合物，该功能物质具有至少一个羟基和一个羧基，可以是游离酸、盐、酰胺或内酯。与传统的含尿素组合物相比，这种组合物非常稳定，并能控制尿素的释放。
• Topical treatment of dermatological disorders associated with reactive or dilated blood vessels
  申请人：——

  公开号：US20040220259A1

  公开（公告）日：2004-11-04

  The invention provides a method of topically treating a dermatological disorder. The method includes topically applying a therapeutically effective amount of a cosmetic or dermatological composition to an affected area of the skin. The composition includes at least one compound that is (i) a polyhydroxy-aldonic acid, (ii) a polyhydroxy-aldonic lactone, (iii) a polyhydroxy-alduronic acid, (iv) a polyhydroxy-alduronic lactone, (v) a polyhydroxy-aldaric acid; (vi) a polyhydroxy-aldaric lactone, and (vii) an organic acid lactone having two or more hydroxyl or ketohydroxyl groups. The dermatological disorder treated is one associated with reactive or dilated blood vessels. Also included in the invention are methods of treating dermatological disorders associated with reactive blood vessels that include topical application of a therapeutically effective amount of a composition. The composition includes at least one compound selected from a compound represented by formula (I): 1 by formula (II): 2 and by formula (III) 3 and a lactone derived from an organic acid having two or more hydroxyl or ketohydroxyl groups.

  本发明提供了一种局部治疗皮肤病的方法。该方法包括将治疗有效量的化妆品或皮肤病组合物局部应用于皮肤的受影响区域。该组合物包括至少一种化合物，它们是(i)多羟基-光气酸，(ii)多羟基-光气内酯，(iii)多羟基-光气酸，(iv)多羟基-光气内酯，(v)多羟基-光气酸；(vi)多羟基-光气内酯，和(vii)具有两个或两个以上羟基或酮羟基的有机酸内酯。治疗的皮肤病是与反应性或扩张性血管有关的疾病。 本发明还包括治疗与反应性血管有关的皮肤病的方法，其中包括局部施用治疗有效量的组合物。该组合物包括至少一种选自式 (I) 所代表化合物的化合物： 1 由式 (II) 表示的化合物： 2 和式 (III) 3 和由具有两个或两个以上羟基或酮羟基的有机酸衍生的内酯。
• Enlargement of mucocutaneous or cutaneous organs and sites with topical compositions
  申请人：Yu J. Ruey

  公开号：US20050171194A1

  公开（公告）日：2005-08-04

  Compositions comprising a hydroxycarboxylic acid, N-acyl-aldosamine, N-acylamino acid or related compound on topical application are beneficial to plump and pout lips, enhance and firm eyelids, enlarge and augment breasts, elongate and expand penis. Because of antioxidant property, certain hydroxycarboxylic acids, N-acyl-aldosamines, N-acylamino acids and related compounds also are useful for topical administration to prevent occurrence of breast cancer or other forms of tumors and cancers.

  由羟基羧酸、N-酰基-醛糖胺、N-酰基氨基酸或相关化合物组成的组合物在局部使用时有利于丰满嘴唇、增强和紧实眼睑、增大和隆起乳房、拉长和扩张阴茎。由于具有抗氧化性，某些羟基羧酸、N-酰基醛胺和 N-酰基氨基酸及相关化合物还可用于局部用药，以预防乳腺癌或其他形式的肿瘤和癌症的发生。