4-(5,6-dihydro-11H-imidazo[2,1-b][3]-benzazepin-11-ylidene)-1-piperidineacetonitrile | 147083-09-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 4-(5,6-dihydro-11H-imidazo[2,1-b][3]-benzazepin-11-ylidene)-1-piperidineacetonitrile
• 英文别名: 2-[4-(5,6-Dihydroimidazo[2,1-b][3]benzazepin-11-ylidene)piperidin-1-yl]acetonitrile
• CAS: 147083-09-8
• 化学式: C₁₉H₂₀N₄
• 分子量: 304.395
• InChiKey: DLLNYCOSBLTSDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] IMIDAZO(2,1-B)(3)BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：WO1992022551A1

  公开（公告）日：1992-12-23

  (EN) The present invention is concerned with novel imidazo[2,1-b][3]benzazepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R1 represents hydrogen, halo, C1-4alkyl or C1-4alkyloxy; R2 represents hydrogen, halo, C1-4alkyl or C1-4alkyloxy; R3 represents hydrogen, C1-4alkyl, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, C1-4alkyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl or hydroxycarbonyl; R4 represents hydrogen, C1-4alkyl, hydroxyC1-4alkyl, phenyl or halo; R5 represents hydrogen, C1-4alkyl or halo; L represents hydrogen; C1-6alkyl; C1-6alkyl substituted with one substituent selected from the group consisting of hydroxy, halo, C1-4alkyloxy, hydroxycarbonyl, C1-4alkyloxycarbonyl, C1-4alkyloxycarbonyl-C1-4alkyloxy, hydroxycarbonylC1-4alkyloxy, C1-4alkyloxycarbonylamino, C1-4alkylaminocarbonyl, C1-4alkylaminocarbonylamino, C1-4alkylaminothiocarbonylamino, aryl, aryloxy and arylcarbonyl; C1-6alkyl substituted with both hydroxy and aryloxy; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het1 (a-1), -Alk-NH-CO-Het2 (a-2) or -Alk-Het3 (a-3); provided that 6,11-dihydro-11-(4-piperidinylidene)-5$i(H)-imidazo[2,1-b][3]benzazepine is excluded, which are useful antiallergic compounds. Compositions comprising said compounds, methods of using and processes for preparing the same.(FR) La présente invention concerne de nouvelles imidazo[2,1-b][3]benzazépines de la formule (I), les sels d'addition pharmaceutiquement acceptables et les formes stéréochimiquement isomerés de celles-ci, dans laquelle chacune des lignes pointillées représente indépendamment une liaison optionnelle; R1 représente hydrogène, halo, C1-4alkyle ou C1-4alkyloxy; R3 représente hydrogène, C1-4alkyle, éthényle substitué avec hydroxycarbonyle ou C1-4alkyloxycarbonyle, C1-4alkyle substitué avec hydroxycarbonyle ou C1-4 alkyloxycarbonyle, hydroxy-C1-4alkyle, formyle ou hydroxycarbonyle; R4 représente hydrogène, C1-4alkyle, hydroxyC1-4alkyle, phényle ou halo; R5 représente hydrogène, C1-4alkyle ou halo; L représente hydrogène; C1-6alkyle; C1-6alkyle substitué avec un substituant choisi dans le groupe comportant hydroxy, halo, C1-4alkyloxy, hydroxycarbonyle, C1-4alkyloxycarbonyle, C1-4alkyloxycarbonyle-C1-4alkyloxy, hydroxycarbonyleC1-4alkyloxycarbonylamino, C1-4alkylaminocarbonyle, C1-4alkylaminocarbonylamino, C1-4alkylaminothiocarbonylamino, aryle, aryloxy et arylcarbonyle; C1-6alkyle substitué avec hydroxy et aryloxy; C3-6alcényle; C3-6alcényle substitué avec aryle; ou bien, L représente un radical de la formule -Alk-Y-Het1 (a-1), -Alk-NH-CO-Het2 (a-2) ou -Alk-Het3 (a-3); à condition que 6,11-dihydro-11-(4-pipéridinylidène)-5-$i(H)-imidazo[2,1-b][3]benzazépine soit exclu; ils sont utilisés comme composés antiallergiques. Compositions contenant lesdits composés, méthodes d'utilisation et procédés pour leur préparation.

  本发明涉及一种新型的Imidazo[2,1-b][3]benzazepines化合物，其化学式为（I），包括其药学上可接受的加合物盐和立体化学异构体，其中每个虚线独立地表示一个可选键；R1代表氢、卤素、C1-4烷基或C1-4烷氧基；R2代表氢、卤素、C1-4烷基或C1-4烷氧基；R3代表氢、C1-4烷基、烯丙基取代的羟基羧酰基或C1-4烷氧羰基、C1-4烷基取代的羟基羧酰基或C1-4烷氧羰基、羟基C1-4烷基、甲酰基或羟基羧酰基；R4代表氢、C1-4烷基、羟基C1-4烷基、苯基或卤素；R5代表氢、C1-4烷基或卤素；L代表氢；C1-6烷基；C1-6烷基取代一个选自羟基、卤素、C1-4烷氧基、羟基羧酰基、C1-4烷氧羰基、C1-4烷氧羰基-C1-4烷氧基、羟基羧酰基C1-4烷氧基、C1-4烷氧羰基氨基、C1-4烷基氨基羰基、C1-4烷基氨基羰基氨基、C1-4烷基氨基硫代羰基氨基、芳基、芳氧基和芳基羧酰基的取代基；C1-6烷基取代羟基和芳氧基；C3-6烯基；C3-6烯基取代芳基；或L代表公式-Alk-Y-Het1（a-1）、-Alk-NH-CO-Het2（a-2）或-Alk-Het3（a-3）的基团；但不包括6,11-二氢-11-(4-哌啶基亚胺)-5$i(H)-imidazo[2,1-b][3]benzazepine，其作为抗过敏化合物。本发明还涉及包括该化合物的组合物、使用方法以及制备该化合物的方法。
• Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0518435A1

  公开（公告）日：1992-12-16

  The present invention is concerned with novel imidazo[2,1-b][3]benzazepines of formula the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R¹ represents hydrogen, halo, C₁₋₄alkyl or C₁₋₄alkyloxy; R² represents hydrogen, halo, C₁₋₄alkyl or C₁₋₄alkyloxy; R³ represents hydrogen, C₁₋₄alkyl, ethenyl substituted with hydroxycarbonyl or C₁₋₄alkyloxycarbonyl, C₁₋₄alkyl substituted with hydroxycarbonyl or C₁₋₄alkyloxycarbonyl, hydroxyC₁₋₄alkyl, formyl or hydroxycarbonyl; R⁴ represents hydrogen, C₁₋₄alkyl, hydroxyC₁₋₄alkyl, phenyl or halo; R⁵ represents hydrogen, C₁₋₄alkyl or halo; L represents hydrogen; C₁₋₆alkyl; C₁₋₆alkyl substituted with one substituent selected from the group consisting of hydroxy, halo, C₁₋₄alkyloxy, hydroxycarbonyl, C₁₋₄alkyloxycarbonyl, C₁₋₄alkyloxycarbonyl-C₁₋₄alkyloxy, hydroxycarbonylC₁₋₄alkyloxy, C₁₋₄alkyloxycarbonylamino, C₁₋₄alkylaminocarbonyl, C₁₋₄alkylaminocarbonylamino, C₁₋₄alkylaminothiocarbonylamino, aryl, aryloxy and arylcarbonyl; C₁₋₆alkyl substituted with both hydroxy and aryloxy; C₃₋₆alkenyl; C₃₋₆alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het¹ (a-1), -Alk-NH-CO-Het² (a-2) or -Alk-Het³ (a-3); provided that 6,11-dihydro-11-(4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine is ecxluded, which are useful antiallergic compounds. Compositions comprising said compounds, methods of using and processes for preparing the same.

  本发明涉及一种新型的imidazo[2,1-b][3]benzazepines化合物，其分子式为药学上可接受的加盐和立体异构体形式，其中每个虚线独立表示可选键；R¹表示氢、卤素、C₁₋₄烷基或C₁₋₄烷氧基；R²表示氢、卤素、C₁₋₄烷基或C₁₋₄烷氧基；R³表示氢、C₁₋₄烷基、烯丙基取代羟基羧酰基或C₁₋₄烷氧羰基、C₁₋₄烷基取代羟基羧酰基或C₁₋₄烷氧羰基、羟基C₁₋₄烷基、甲酰基或羟基羧酰基；R⁴表示氢、C₁₋₄烷基、羟基C₁₋₄烷基、苯基或卤素；R⁵表示氢、C₁₋₄烷基或卤素；L表示氢、C₁₋₆烷基、取代一个取代基的C₁₋₆烷基，所述取代基选自羟基、卤素、C₁₋₄烷氧基、羟基羧酰基、C₁₋₄烷氧羰基、C₁₋₄烷氧羰基-C₁₋₄烷氧基、羟基羧酰基C₁₋₄烷氧基、C₁₋₄烷氧羰基氨基、C₁₋₄烷氨基羰基、C₁₋₄烷氨基羰基氨基、C₁₋₄烷氨基硫代羰基氨基、芳基、芳氧基和芳基羧酰基；取代羟基和芳氧基的C₁₋₆烷基；C₃₋₆烯基；取代芳基的C₃₋₆烯基；或L表示式-Alk-Y-Het¹(a-1)、-Alk-NH-CO-Het²(a-2)或-Alk-Het³(a-3)的基团；但不包括6,11-二氢-11-(4-哌啶亚甲基)-5H-imidazo[2,1-b][3]benzazepine，它们是有用的抗过敏化合物。本发明还涉及包含上述化合物的组合物、使用方法和制备方法。
• IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0588858B1

  公开（公告）日：2003-09-17
• US5468743A
  申请人：——

  公开号：US5468743A

  公开（公告）日：1995-11-21