Methanesulfonic acid (1R,2R,5S,6R)-5-azido-2,6-dimethyl-cyclooctyl ester | 874292-46-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Methanesulfonic acid (1R,2R,5S,6R)-5-azido-2,6-dimethyl-cyclooctyl ester
• CAS: 874292-46-3
• 化学式: C₁₁H₂₁N₃O₃S
• 分子量: 275.372
• InChiKey: ZJSQFWVRWLBMPW-CHWFTXMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.86
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  92.13
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  Methanesulfonic acid (1R,2R,5S,6R)-5-azido-2,6-dimethyl-cyclooctyl ester 在 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 (1S,2R,5S,6R)-2,6-Dimethyl-9-aza-bicyclo[3.3.1]nonane
  参考文献：
  名称：

  C2-Symmetric nitroxides and their potential as enantioselective oxidants

  摘要：

  The synthesis and evaluation of four C-2-symmetric nitroxides are presented. The nitroxides were evaluated for their ability to mediate the oxidation of several alcohols and found to have good catalytic activity. One enantioenriched nitroxide was found to kinetically resolve selected secondary alcohols with very modest selectivities. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.09.016
• 作为产物：
  描述：

  Methanesulfonic acid (1R,2R,5R,6R)-5-hydroxy-2,6-dimethyl-cyclooctyl ester 在 sodium azide 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 生成 Methanesulfonic acid (1R,2R,5S,6R)-5-azido-2,6-dimethyl-cyclooctyl ester
  参考文献：
  名称：

  C2-Symmetric nitroxides and their potential as enantioselective oxidants

  摘要：

  The synthesis and evaluation of four C-2-symmetric nitroxides are presented. The nitroxides were evaluated for their ability to mediate the oxidation of several alcohols and found to have good catalytic activity. One enantioenriched nitroxide was found to kinetically resolve selected secondary alcohols with very modest selectivities. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.09.016