延胡索乙素N氧化物 | 57906-85-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 中文名称: 延胡索乙素N氧化物
• 中文别名: 延胡索乙素 N氧化物
• 英文名称: corynoxidine
• 英文别名: (7S,13aS)-2,3,9,10-tetramethoxy-7-oxido-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium
• CAS: 57906-85-1
• 化学式: C₂₁H₂₅NO₅
• 分子量: 371.433
• InChiKey: QYEMUDHNCZHUKC-JTSKRJEESA-N

物化性质

• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  5

制备方法与用途

生物活性

(-)-Corynoxidine 分离自延胡索 Corydalis speciosa，是一种乙酰胆碱酯酶 acetylcholinesterase 抑制剂，IC50 值为 89.0 μM。 (-)-Corynoxidine 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌菌株有不同程度的抗菌活性。

靶点

IC50: 89.0 μM (acetylcholinesterase)

文献信息

• COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND ITS PRODUCTION PROCESS
  申请人：Eleonor SPRL

  公开号：EP3672575A1

  公开（公告）日：2020-07-01
• COMPOSITION FOR TREATMENT OF HAIR LOSS AND REGROWTH STIMULATION
  申请人：Nina Elya Ltd.

  公开号：US20180098933A1

  公开（公告）日：2018-04-12

  This invention is directed to a composition for treating and preventing hair loss in male and female, for regrowth stimulation of hair in male and female, for replenishing the previously colored hair in male and female, and for stimulation of healthy and strong finger nail growth, wherein the composition is a nutrition supplement.
• [EN] A COMPOSITION FOR TREATMENT OF HAIR LOSS AND REGROWTH STIMULATION<br/>[FR] COMPOSITION POUR LE TRAITEMENT DE LA CHUTE DES CHEVEUX ET LA STIMULATION DE LA REPOUSSE
  申请人：NINA ELYA LTD

  公开号：WO2016199147A1

  公开（公告）日：2016-12-15

  This invention is directed to a composition for treating and preventing hair loss in male and female, for regrowth stimulation of hair in male and female, for replenishing the previously colored hair in male and female, and for stimulation of healthy and strong finger nail growth, wherein the composition is a nutrition supplement.
• [EN] COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND ITS PRODUCTION PROCESS<br/>[FR] COMPOSITION COMPRENANT AU MOINS UN ALCALOÏDE DE TYPE PROTOBERBÉRINE ET SON PROCÉDÉ DE PRODUCTION
  申请人：ELEONOR SPRL

  公开号：WO2019038430A1

  公开（公告）日：2019-02-28

  Composition comprising at least one protoberberine alkaloid and its production process This invention concerns a composition in the form of an extrudate containing at least one protoberberine alkaloid as active substance together with at least one polymer, said protoberberine alkaloid consisting of at least a first amorphous phase and possibly a second crystalline phase. This invention also concerns the process for producing such a composition and its use.
• [EN] COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERINE ALKALOID AND METHOD FOR MANUFACTURING SAME<br/>[FR] COMPOSITION COMPRENANT AU MOINS UN ALCALOÏDE DE PROTOBERBÉRINE ET SON PROCÉDÉ DE FABRICATION
  申请人：ELEONOR SPRL

  公开号：WO2021209623A1

  公开（公告）日：2021-10-21

  La présente invention porte sur une composition sous forme d'un extrudat thermoformé comprenant au moins un alcaloïde de protoberbérine et au moins un polymère d'origine naturelle et/ou synthétique choisi dans le groupe constitué des protéines d'origine naturelle et/ou synthétique, des acides aminés, des peptides et des polypeptides d'origine naturelle et/ou synthétique, des lipides d'origine naturelle et/ou synthétique, des dextrines d'origine naturelle et/ou synthétique, des alginates d'origine naturelle et/ou synthétique, des oligosaccharides d'origine naturelle et/ou synthétique, des cyclodextrines d'origine naturelle et/ou synthétique, des hyaluronates d'origine naturelle et/ou synthétique, des carraghénanes d'origine naturelle et/ou synthétique, de leurs dérivés et de leurs mélanges.