4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline | 347161-74-4

分子结构分类

有机化合物 - 有机氧化合物

中文名称

——

中文别名

——

英文名称

4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline

英文别名

3-fluoro-4-(6,7-dimethoxyquinolin-4-yloxy)aniline；4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluorophenylamine；4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-aniline；4-((6,7-dimethoxyquinoline-4-yl)oxy)-3-fluoroaniline；4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorobenzenamine；4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoroaniline

4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline化学式

CAS

347161-74-4

化学式

C₁₇H₁₅FN₂O₃

mdl

——

分子量

314.316

InChiKey

SIDZXXQYQLBOHZ-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

3.1
重原子数：

23
可旋转键数：

4
环数：

3.0
sp3杂化的碳原子比例：

0.12
拓扑面积：

66.6
氢给体数：

1
氢受体数：

6

SDS

SDS：4d37fad2585f90ce4770ea3670a49c5c

查看

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
4-(2-氟-4-硝基苯氧基)-6,7-二甲氧基喹啉	4-(2-fluoro-4-nitrophenoxy)-6,7-dimethoxyquinoline	516526-44-6	C₁₇H₁₃FN₂O₅	344.299
4-(2-氟-4-硝基苯氧基)-6-甲氧基-7-(苄氧基)喹啉	7-benzyloxy-4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinoline	479690-03-4	C₂₃H₁₇FN₂O₅	420.397
4-氯 -6,7-二甲氧基喹啉	6,7-dimethoxy-4-chloroquinoline	35654-56-9	C₁₁H₁₀ClNO₂	223.659
4-羟基-6,7-二甲氧基喹啉	6,7-dimethoxyquinoline-4-ol	13425-93-9	C₁₁H₁₁NO₃	205.213

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluoro-N-methylaniline	1000850-86-1	C₁₈H₁₇FN₂O₃	328.343
——	4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl isothiocyanate	911389-80-5	C₁₈H₁₃FN₂O₃S	356.377
——	4-(4-azido-2-fluoro-phenoxy)-6,7-dimethoxy-quinoline	1198110-04-1	C₁₇H₁₃FN₄O₃	340.314
——	4-(2-fluoro-4-isocyanato-phenoxy)-6,7-dimethoxy-quinoline	1033263-79-4	C₁₈H₁₃FN₂O₄	340.311
——	1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(4-fluorophenyl)-[(11)C]-urea	1198110-06-3	C₂₄H₁₉F₂N₃O₄	450.418
——	1-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)urea	1033263-75-0	C₂₄H₁₉F₂N₃O₄	451.429
——	phenyl N-4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenylcarbamate	911389-82-7	C₂₄H₁₉FN₂O₅	434.424
——	1-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(2-fluorophenyl)urea	1033263-76-1	C₂₄H₁₉F₂N₃O₄	451.429
——	4-(6,7-dimethoxyquinolin-4-yloxy)-N-(1-ethoxy-2,2,2-trifluoroethyl)-3-fluoroaniline	1000850-92-9	C₂₁H₂₀F₄N₂O₄	440.394
——	4-nitrophenyl 4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenylcarbamate	1000850-83-8	C₂₄H₁₈FN₃O₇	479.421
——	N-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-N'-phenethyl-oxalamide	——	C₂₇H₂₄FN₃O₅	489.503
——	N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-4,4,4-trifluoro-3-(phenylamino)butanamide	1000850-69-0	C₂₇H₂₃F₄N₃O₄	529.491
——	3-N'-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-N-(4-fluorophenyl)oxetane-3,3-dicarboxamide	1426312-40-4	C₂₈H₂₃F₂N₃O₆	535.504
——	N-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-N'-[2-(4-fluorophenyl)acetyl]thiourea	——	C₂₆H₂₁F₂N₃O₄S	509.533
——	N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N'-[(1S)-1-(4-fluorophenyl)ethyl]urea	——	C₂₆H₂₃F₂N₃O₄	479.483
——	N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N'-(3-methyl-5-isoxazolyl)urea	475108-21-5	C₂₂H₁₉FN₄O₅	438.415
——	N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N'-[1-(1,3-thiazol-2-yl)ethyl]urea	——	C₂₃H₂₁FN₄O₄S	468.509
——	1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)amino)-1-oxopropan-2-yl 2-naphthoate	——	C₃₁H₂₅FN₂O₆	540.548
——	N-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-2-trifluoromethylbenzenesulfonamide	1192298-98-8	C₂₄H₁₈F₄N₂O₅S	522.477
——	N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-methyl-2-oxo-1-phenylpyrrolidine-3-carboxamide	1361572-94-2	C₂₉H₂₆FN₃O₅	515.541
——	1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)amino)-3,3-dimethyl-1-oxobutan-2-yl 3-fluorobenzoate	——	C₃₀H₂₈F₂N₂O₆	550.559
——	1-benzyl-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-2-oxopyrrolidine-3-carboxamide	1361572-97-5	C₂₉H₂₆FN₃O₅	515.541
——	6-(6,7-dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-ylamine	——	C₁₈H₁₄FN₃O₃S	371.392
——	3-benzyl-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-2-oxopyrrolidine-1-carboxamide	1361573-13-8	C₂₉H₂₆FN₃O₅	515.541
——	N-(4-((6,7-dimethoxynaphthalen-1-yl)oxy)-3-fluorophenyl)-3-fluoro-2-oxo-1-phenylpyrrolidine-3-carboxamide	1361572-95-3	C₂₈H₂₃F₂N₃O₅	519.505
——	5-{[4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl]amino}-3-(4-fluorophenyl)- 1,6-naphthyridin-4(1H)-one	——	C₃₁H₂₂F₂N₄O₄	552.537
——	N-[6-(6,7-dimethoxy-quinolin-4-yloxy)-5-fluoro-benzothiazol-2-yl]-2-phenyl-acetamide	——	C₂₆H₂₀FN₃O₄S	489.527
——	N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-(2-(dimethylamino)ethyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamide	1361030-62-7	C₃₁H₂₉F₂N₅O₄	573.599
——	5-bromo-N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide	——	C₂₉H₂₁BrFN₃O₅	590.405
——	N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluorophenyl)pyrazole-3-carboxamide	1361030-42-3	C₂₉H₂₄F₂N₄O₅	546.53
——	N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamide	1612842-55-3	C₂₉H₂₀F₂IN₃O₅	655.396

反应信息

作为反应物：

描述：

4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺作用下，以 N,N-二甲基甲酰胺为溶剂，反应 0.25h，以74%的产率得到N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

参考文献：