1,3-bis(di(4-methoxyphenyl)phosphino)propane | 111216-21-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,3-bis(di(4-methoxyphenyl)phosphino)propane
• 英文别名: Phosphine, 1,3-propanediylbis[bis(4-methoxyphenyl)-；3-bis(4-methoxyphenyl)phosphanylpropyl-bis(4-methoxyphenyl)phosphane
• CAS: 111216-21-8
• 化学式: C₃₁H₃₄O₄P₂
• 分子量: 532.556
• InChiKey: NITFBBJDNBZGRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-bis(di(4-methoxyphenyl)phosphino)propane 在 copper(l) iodide 、 二乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.5h， 生成
  参考文献：
  名称：

  Building Blocks for Molecular Polygons Based on Platinum Vertices and Polyynediyl Edges

  摘要：

  (for 5a) a luminescent diplatinum byproduct with trans Pt((C≡C)2SiMe3)2 units. 5a and 6b hydrolyze in the presence of F– to 3a,b (92–93%). Reaction of 2a and 3a (HNEt2/cat. CuI) affords the Pt4C16 polygon ([(CH2(CH2P(p-C6H4OMe)2)2)Pt(C≡C)2]4 as an H2NEt2+ Cl– adduct (66%). The 13C{1H} NMR spectra of 3a–d, 5a, and 6a,b,d feature complex AMXX′ (CPtPP′) spin systems, and simulations allow J values to be

  DOI：

  10.1021/acs.organomet.2c00573
• 作为产物：
  描述：

  bis(4-methoxyphenyl)phosphine oxide 在 甲基二乙氧基硅烷 、 双(对硝基苯基)磷酸酯 、 sodium hydride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 51.5h， 生成 1,3-bis(di(4-methoxyphenyl)phosphino)propane
  参考文献：
  名称：

  铑催化2-（氮杂环丁烷-3-亚烷基）乙酸盐和类似物的CC键断裂/偶联†

  摘要：

  通过“共轭加成/β-C裂解/质子化”策略研究了2-（氮杂环丁烷-3-亚烷基）乙酸酯与铑配合物催化的芳基硼酸的CC键裂解/偶联。

  DOI：

  10.1039/c9cc06446j
• 作为试剂：
  描述：

  二氧化碳 、 4-乙酰苯硼酸新戊二醇酯 在 [Rh(OH)(cod)]2 1,3-bis(di(4-methoxyphenyl)phosphino)propane 、 cesium fluoride 作用下， 以 1,4-二氧六环 为溶剂， 以74%的产率得到4-乙酰基苯甲酸
  参考文献：
  名称：

  Rhodium(I)-Catalyzed Carboxylation of Aryl- and Alkenylboronic Esters with CO₂

  摘要：

  When the esters of arylboronic acids with 2,2-dimethylpropan-1,3-diol were treated with a catalytic amount of [Rh(OH)(cod)]2 in the presence of 1,3-bis(diphenylphosphino)propane and CsF in dioxane at 60 degrees C under carbon dioxide atmosphere, the benzoic acid derivatives were obtained in good yields. Reactions of alkenylboronic esters also proceeded under similar conditions to give alpha,beta-unsaturated carboxylic acids. As these boronic esters are now easily available through coupling or direct borylation reactions, this method would be a useful method for the preparation of various functionalized aryl- and alkenyl-carboxylic acids.

  DOI：

  10.1021/ja061232m

文献信息

• Synthesis of Arylacetaldehydes by Iridium‐Catalyzed Arylation of Vinylene Carbonate with Arylboronic Acids
  作者：Zhe Wang、Fei Xue、Tamio Hayashi

  DOI：10.1002/anie.201906148

  日期：2019.8.5

  synthesis of arylacetaldehydes by carbon–carbon bond formation between formylmethyl and aryl groups has been realized by the reaction of vinylene carbonate with arylboronic acids in the presence of an iridium/bisphosphine catalyst and a catalytic amount of tetrahydroxydiboron.

  在铱/双膦催化剂和催化量的四羟基二硼存在下，碳酸亚乙烯酯与芳基硼酸的反应已实现了通过甲酰甲基与芳基之间的碳-碳键形成一步合成芳基乙醛。
• Developing Ru-Catalysts for Asymmetric Transfer Hydrogenation of Acyclic Imines
  作者：Dongxu He、Chen Xu、Xiangyou Xing

  DOI：10.1021/acs.orglett.2c03385

  日期：2022.11.18

  Asymmetric transfer hydrogenation (ATH) of acyclic imines has been rarely reported by using Ru-based catalysts. In this manuscript, employing Ru-catalysts with minimal stereogenicity in combination with formic acid/triethylamine as the hydrogen donor enables a highly efficient ATH of N-diphenylphosphinyl acyclic imines. These substrates that include various aryl alkyl and heteroaryl alkyl substituted imines

  使用 Ru 基催化剂很少报道无环亚胺的不对称转移氢化 (ATH)。在这份手稿中，使用具有最小立体异构性的 Ru 催化剂与甲酸/三乙胺作为氢供体相结合，可以实现N-二苯基膦基无环亚胺的高效 ATH 。这些包含各种芳基烷基和杂芳基烷基取代亚胺的底物都与该催化体系相容，并以优异的对映体过量 (ee's) 和产率获得相应的还原胺。
• Novel catalyst compositions and process for copolymerizing ethene and carbon monoxide
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0222454A2

  公开（公告）日：1987-05-20

  Novel catalyst compositions for copolymerizing ethene and carbon monoxide, characterized in that they comprise: a) a compound of a Group VIII metal chosen from palladium, cobalt and nickel, b) an anion of an acid with a pKa of less than 6, and c) a bidentate ligand of the general formula R¹R²-M-R-M-R³R⁴, wherein M represents phosphorus, arsenic or antimony, R is a bivalent organic bridging group containing two or three carbon atoms in the bridge and R¹, R², R³ and R⁴ represent hydro­carbon groups which may or may not be substituted with polar groups, on the understanding that at least one hydrogen atom in at least one of the groups R¹, R², R³ and R⁴ is substituted with a polar substituent.

  用于乙烯和一氧化碳共聚的新型催化剂组合物，其特征在于它们包括 a) 选自钯、钴和镍的第八族金属化合物、 b) pKa 小于 6 的酸阴离子，以及 c) 通式为 R¹R²-M-R-M-R³R⁴的双叉配体，其中 M 代表磷、砷或锑，R 是桥中含有两个或三个碳原子的二价有机桥基，R¹、R²、R³ 和 R⁴ 代表烃基，这些烃基可以被极性基团取代，也可以不被极性基团取代，前提是 R¹、R²、R³ 和 R⁴ 中至少有一个基团中的至少一个氢原子被极性取代基取代。
• Process for the preparation of polymers
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0246683A2

  公开（公告）日：1987-11-25

  Process for the preparation of polymers, characterized in that a mixture of carbon monoxide and one or more olefini­cally unsaturated organic compounds is polymerized by using a catalyst composition based upon a) a palladium compound, b) a bidentate ligand of the general formula R¹R²-M-R-M-R³R⁴ wherein M represents phosphorus, arsenic or antimony, R¹, R², R³ and R⁴ represent hydrocarbyl groups which may or may not be substituted with polar groups and R represents a bivalent organic bridging group containing at least two carbon atoms in the bridge, and c) a halide of tin or germanium, on the understanding that the presence of this halide is not compulsory when the composition contains a palladium halide.

  制备聚合物的工艺，其特征在于一氧化碳和一种或多种烯烃不饱和有机化合物的混合物通过使用基于以下成分的催化剂组合物进行聚合反应 a) 钯化合物 b) 通式为 R¹R²-M-R-M-R³R⁴ 的双齿配体，其中 M 代表磷、砷或锑，R¹、R²、R³ 和 R⁴ 代表可能被或不被极性基团取代的烃基，R 代表在桥中至少含有两个碳原子的二价有机桥基，以及 c) 锡或锗的卤化物，但在组合物中含有钯卤化物时，这种卤化物的存在不是强制性 的。
• Catalyst compositions and process for preparing olefin/CO copolymers
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0254343A1

  公开（公告）日：1988-01-27

  1. Novel catalyst compositions characterized in that they are based upon: a) a palladium compound, b) a quaternary phosphonium salt of an acid with a pKa of less than 2, with the proviso that the acid is not a hydrohalogenic acid or a mixture of such a salt and acid, and c) either a phosphorus bidentate ligand of the general formula R¹R²-P-R-P-R³R⁴, wherein R¹, R², R³ and R⁴ are hydrocarbyl groups which may or may not be substituted with polar groups and R represents a bivalent organic bridging group containing at least two carbon atoms in the bridge, or a nitrogen bidentate ligand of the general formula wherein X and Y are similar or dissimilar bridging groups, each containing three or four atoms in the bridge at least two of which are carbon atoms.

  1.新型催化剂组合物，其特征在于： a) 钯化合物、 b) 一种 pKa 小于 2 的酸的季鏻盐，但该酸不是氢卤酸或这种盐和酸的混合物，以及 c) 通式为 R¹R²-P-R-P-R³R⁴的磷双叉配体，其中 R¹、R²、R³ 和 R⁴ 为可能被或可能不被极性基团取代的烃基，R 代表桥中至少含有两个碳原子的二价有机桥基，或通式为氮双叉配体。 其中 X 和 Y 是相似或不相似的桥基，每个桥基含有三个或四个原子，其中至少两个是碳原子。