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    —— ethyl (6S)-6-(4-tert-butylphenyl)-4-[[(3S)-4-(2-methoxyacetyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C27H40N4O5
    ethyl (6S)-6-(4-tert-butylphenyl)-4-[[(3S)-4-(2-methoxyacetyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (2Z)-2-[3-[[5-(4-chlorophenyl)-1,3-oxazol-2-yl]methyl]-4-oxo-1,3-thiazolidin-2-ylidene]acetate —— C17H15ClN2O4S
    ethyl (2Z)-2-[3-[[5-(4-chlorophenyl)-1,3-oxazol-2-yl]methyl]-4-oxo-1,3-thiazolidin-2-ylidene]acetate
    —— ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-6-(4-chlorophenyl)-3-ethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C26H38ClN5O4
    ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-6-(4-chlorophenyl)-3-ethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-6-(2,4-dimethylphenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C27H41N5O4
    ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-6-(2,4-dimethylphenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— (E)-2-cyano-N-(4-ethylphenyl)-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]prop-2-enamide —— C23H21FN4O
    (E)-2-cyano-N-(4-ethylphenyl)-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]prop-2-enamide
    —— ethyl (4S)-6-[(4-cyclopropyl-5-indol-3-ylidene-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-4-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C22H24N6O3S
    ethyl (4S)-6-[(4-cyclopropyl-5-indol-3-ylidene-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-4-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (6S)-4-[[(3S)-4-(2-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(2,3-dichlorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C27H29Cl3N4O4
    ethyl (6S)-4-[[(3S)-4-(2-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(2,3-dichlorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— (E)-2-(1,3-benzothiazol-2-yl)-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]prop-2-enenitrile —— C21H15FN4S
    (E)-2-(1,3-benzothiazol-2-yl)-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]prop-2-enenitrile
    —— (E)-2-cyano-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]-N-(4-methylphenyl)prop-2-enamide —— C22H19FN4O
    (E)-2-cyano-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]-N-(4-methylphenyl)prop-2-enamide
    —— ethyl (6R)-4-[[(3S)-4-(cyclobutanecarbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-6-(3-phenoxyphenyl)-1,6-dihydropyrimidine-5-carboxylate —— C31H38N4O5
    ethyl (6R)-4-[[(3S)-4-(cyclobutanecarbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-6-(3-phenoxyphenyl)-1,6-dihydropyrimidine-5-carboxylate
    —— (E)-2-cyano-3-[4-(cyanomethoxy)phenyl]-N-(3,4-dimethylphenyl)prop-2-enamide —— C20H17N3O2
    (E)-2-cyano-3-[4-(cyanomethoxy)phenyl]-N-(3,4-dimethylphenyl)prop-2-enamide
    —— ethyl (6R)-4-[[(3S)-4-benzoyl-3-methylpiperazin-1-yl]methyl]-6-(4-chlorophenyl)-3-ethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C28H33ClN4O4
    ethyl (6R)-4-[[(3S)-4-benzoyl-3-methylpiperazin-1-yl]methyl]-6-(4-chlorophenyl)-3-ethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6S)-6-(2,3-dichlorophenyl)-3-ethyl-4-[[(3S)-3-methyl-4-[4-(trifluoromethyl)benzoyl]piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C29H31Cl2F3N4O4
    ethyl (6S)-6-(2,3-dichlorophenyl)-3-ethyl-4-[[(3S)-3-methyl-4-[4-(trifluoromethyl)benzoyl]piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-3-methyl-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-6-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate —— C25H34F3N5O4
    ethyl (6R)-3-methyl-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-6-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-6-(4-tert-butylphenyl)-4-[[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C30H44N4O4
    ethyl (6R)-6-(4-tert-butylphenyl)-4-[[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(4-fluorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(3-fluorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C27H30F2N4O4
    ethyl (6R)-4-[[(3S)-4-(4-fluorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(3-fluorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— (E)-2-cyano-3-[4-(cyanomethoxy)phenyl]-N-cyclohexylprop-2-enamide —— C18H19N3O2
    (E)-2-cyano-3-[4-(cyanomethoxy)phenyl]-N-cyclohexylprop-2-enamide
    —— ethyl (6R)-4-[[(3S)-4-(4-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate —— C28H33ClN4O4
    ethyl (6R)-4-[[(3S)-4-(4-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-benzoyl-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-6-(4-propan-2-ylphenyl)-1,6-dihydropyrimidine-5-carboxylate —— C30H38N4O4
    ethyl (6R)-4-[[(3S)-4-benzoyl-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-6-(4-propan-2-ylphenyl)-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(2-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(3-fluorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C27H30ClFN4O4
    ethyl (6R)-4-[[(3S)-4-(2-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(3-fluorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(4-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-[4-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate —— C29H32ClF3N4O4
    ethyl (6R)-4-[[(3S)-4-(4-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-[4-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate
    —— (E)-2-cyano-N-(furan-2-ylmethyl)-3-[1-(2-methylphenyl)-3-phenylpyrazol-4-yl]prop-2-enamide —— C25H20N4O2
    (E)-2-cyano-N-(furan-2-ylmethyl)-3-[1-(2-methylphenyl)-3-phenylpyrazol-4-yl]prop-2-enamide
    —— ethyl (6S)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-6-(2-fluorophenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C26H38FN5O4
    ethyl (6S)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-6-(2-fluorophenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-6-(2,5-dimethylphenyl)-4-[[(3S)-4-(4-methoxybenzoyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C30H38N4O5
    ethyl (6R)-6-(2,5-dimethylphenyl)-4-[[(3S)-4-(4-methoxybenzoyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl 2,4-dimethyl-5-[(Z)-(4-oxo-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1H-pyrrole-3-carboxylate —— C16H18N2O3S2
    ethyl 2,4-dimethyl-5-[(Z)-(4-oxo-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1H-pyrrole-3-carboxylate
    —— ethyl (6S)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-6-(2-fluorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C25H36FN5O4
    ethyl (6S)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-6-(2-fluorophenyl)-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— (E)-2-cyano-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]-N-[(1S,2S)-2-methylcyclohexyl]prop-2-enamide —— C22H25FN4O
    (E)-2-cyano-3-[1-(4-fluorophenyl)-3,5-dimethylpyrazol-4-yl]-N-[(1S,2S)-2-methylcyclohexyl]prop-2-enamide
    —— (E)-3-(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-2-cyano-N-(2-methylphenyl)prop-2-enamide —— C20H17ClN2O3
    (E)-3-(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-2-cyano-N-(2-methylphenyl)prop-2-enamide
    —— ethyl (6R)-6-(4-tert-butylphenyl)-4-[[(3S)-4-(furan-2-carbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C29H38N4O5
    ethyl (6R)-6-(4-tert-butylphenyl)-4-[[(3S)-4-(furan-2-carbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-3-ethyl-4-[[(3S)-4-(furan-2-carbonyl)-3-methylpiperazin-1-yl]methyl]-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate —— C26H32N4O5
    ethyl (6R)-3-ethyl-4-[[(3S)-4-(furan-2-carbonyl)-3-methylpiperazin-1-yl]methyl]-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6S)-6-(2,4-dichlorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C24H33Cl2N5O4
    ethyl (6S)-6-(2,4-dichlorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— (E)-2-cyano-N-(2-methylphenyl)-3-quinoxalin-2-ylprop-2-enamide —— C19H14N4O
    (E)-2-cyano-N-(2-methylphenyl)-3-quinoxalin-2-ylprop-2-enamide
    —— (E)-N-butyl-3-(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-2-cyanoprop-2-enamide —— C17H19ClN2O3
    (E)-N-butyl-3-(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-2-cyanoprop-2-enamide
    —— ethyl (6R)-6-(3-fluorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(phenylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C27H32FN5O4
    ethyl (6R)-6-(3-fluorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(phenylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl 5-[(E)-2-cyano-3-[[(1S,2R)-2-methylcyclohexyl]amino]-3-oxoprop-1-enyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C20H27N3O3
    ethyl 5-[(E)-2-cyano-3-[[(1S,2R)-2-methylcyclohexyl]amino]-3-oxoprop-1-enyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— ethyl (6R)-3-ethyl-4-[[(3S)-3-methyl-4-(4-methylbenzoyl)piperazin-1-yl]methyl]-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate —— C29H36N4O4
    ethyl (6R)-3-ethyl-4-[[(3S)-3-methyl-4-(4-methylbenzoyl)piperazin-1-yl]methyl]-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (3S)-1-[(3R)-1-(3-chloro-4-methylphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-3-carboxylate —— C20H25ClN2O4
    ethyl (3S)-1-[(3R)-1-(3-chloro-4-methylphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-3-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(4-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-6-(3-methylphenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C29H35ClN4O4
    ethyl (6R)-4-[[(3S)-4-(4-chlorobenzoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-6-(3-methylphenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-3-methyl-6-(2-methylphenyl)-4-[[(3S)-3-methyl-4-(phenylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C28H35N5O4
    ethyl (6R)-3-methyl-6-(2-methylphenyl)-4-[[(3S)-3-methyl-4-(phenylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-6-(3-fluorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C24H34FN5O4
    ethyl (6R)-6-(3-fluorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-[4-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate —— C27H38F3N5O4
    ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-[4-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-6-(3-methylphenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C26H39N5O4
    ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-6-(3-methylphenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-3-methyl-6-(2-methylphenyl)-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C25H37N5O4
    ethyl (6R)-3-methyl-6-(2-methylphenyl)-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-3-ethyl-4-[[(3S)-4-(4-fluorobenzoyl)-3-methylpiperazin-1-yl]methyl]-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate —— C28H33FN4O4
    ethyl (6R)-3-ethyl-4-[[(3S)-4-(4-fluorobenzoyl)-3-methylpiperazin-1-yl]methyl]-2-oxo-6-phenyl-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(1,3-benzodioxole-5-carbonyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-[4-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate —— C30H33F3N4O6
    ethyl (6R)-4-[[(3S)-4-(1,3-benzodioxole-5-carbonyl)-3-methylpiperazin-1-yl]methyl]-3-ethyl-2-oxo-6-[4-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-6-(4-chlorophenyl)-4-[[(3S)-4-(furan-2-carbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C25H29ClN4O5
    ethyl (6R)-6-(4-chlorophenyl)-4-[[(3S)-4-(furan-2-carbonyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-3-ethyl-4-[[(3S)-4-(3-fluorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(3-methylphenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C29H35FN4O4
    ethyl (6R)-3-ethyl-4-[[(3S)-4-(3-fluorobenzoyl)-3-methylpiperazin-1-yl]methyl]-6-(3-methylphenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-6-(4-chlorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(3-methylbutanoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C25H35ClN4O4
    ethyl (6R)-6-(4-chlorophenyl)-3-methyl-4-[[(3S)-3-methyl-4-(3-methylbutanoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-3-methyl-6-(3-methylphenyl)-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate —— C25H37N5O4
    ethyl (6R)-3-methyl-6-(3-methylphenyl)-4-[[(3S)-3-methyl-4-(propan-2-ylcarbamoyl)piperazin-1-yl]methyl]-2-oxo-1,6-dihydropyrimidine-5-carboxylate
    —— ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-6-(3-phenoxyphenyl)-1,6-dihydropyrimidine-5-carboxylate —— C31H41N5O5
    ethyl (6R)-4-[[(3S)-4-(tert-butylcarbamoyl)-3-methylpiperazin-1-yl]methyl]-3-methyl-2-oxo-6-(3-phenoxyphenyl)-1,6-dihydropyrimidine-5-carboxylate