6-chloro-3-(3,4-dimethoxyphenyl)-4-methyl-2H-chromen-2-one | 720674-87-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 6-chloro-3-(3,4-dimethoxyphenyl)-4-methyl-2H-chromen-2-one
• 英文别名: 6-chloro-3-(3,4-dimethoxyphenyl)-4-methylchromen-2-one
• CAS: 720674-87-3
• 化学式: C₁₈H₁₅ClO₄
• mdl: MFCD02660637
• 分子量: 330.768
• InChiKey: LHOZADRUULOPRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-chloro-3-(3,4-dimethoxyphenyl)-4-methyl-2H-chromen-2-one 在 三溴化硼 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 4.0h， 以88%的产率得到6-chloro-3-(3,4-dihydroxyphenyl)-4-methyl-2H-chromen-2-one
  参考文献：
  名称：

  A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity

  摘要：

  A series of coumarin analogues bearing a substituted phenyl ring on position 3 were synthesized via a novel methodology, through an intermolecular condensation reaction of 2-hydroxyacetophenones and 2-hydroxybenzaldehyde, with imidazolyl phenylacetic acid active intermediates. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). Moreover, the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.022
• 作为产物：
  描述：

  2-羟基-5-氯苯乙酮 、 2-(3,4-Dimethoxyphenyl)-1-imidazol-1-ylethanone 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 生成 6-chloro-3-(3,4-dimethoxyphenyl)-4-methyl-2H-chromen-2-one
  参考文献：
  名称：

  A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity

  摘要：

  A series of coumarin analogues bearing a substituted phenyl ring on position 3 were synthesized via a novel methodology, through an intermolecular condensation reaction of 2-hydroxyacetophenones and 2-hydroxybenzaldehyde, with imidazolyl phenylacetic acid active intermediates. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). Moreover, the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.022

文献信息

• Structural modifications of coumarin derivatives: Determination of antioxidant and lipoxygenase (LOX) inhibitory activity
  作者：Marina Roussaki、Konstantinos Zelianaios、Eleni Kavetsou、Stylianos Hamilakis、Dimitra Hadjipavlou-Litina、Christos Kontogiorgis、Thalia Liargkova、Anastasia Detsi

  DOI：10.1016/j.bmc.2014.10.008

  日期：2014.12

  In the present project, a series of coumarin analogues, were synthesised and evaluated for their antioxidant and soybean lipoxygenase inhibitory activity. A variety of structural modifications on the coumarin scaffold revealed interesting structure-activity relationships concerning the different biological assays. Prenyloxy-coumarins 9 and 10 displayed the best combined inhibition of lipid peroxidation and soybean lipoxygenase. Thiocoumarins 11 and 14 were identified as potent lipoxygenase inhibitors whereas hydrazone analogues 15 and 16 were efficient DPPH radical scavengers. (C) 2014 Elsevier Ltd. All rights reserved.
• A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity
  作者：Marina Roussaki、Christos A. Kontogiorgis、Dimitra Hadjipavlou-Litina、Stylianos Hamilakis、Anastasia Detsi

  DOI：10.1016/j.bmcl.2010.05.022

  日期：2010.7

  A series of coumarin analogues bearing a substituted phenyl ring on position 3 were synthesized via a novel methodology, through an intermolecular condensation reaction of 2-hydroxyacetophenones and 2-hydroxybenzaldehyde, with imidazolyl phenylacetic acid active intermediates. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). Moreover, the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity. (c) 2010 Elsevier Ltd. All rights reserved.