An Economical and Practical Synthesis of<i>rac</i>-(<i>Z</i>)-β-Santalol: Application of a Scriabine-Inspired Reaction to Alkenes Results in the One-Step Preparation of a Key Intermediate
作者:Anthony A. Birkbeck、Xavier Marquet、Pascal Millet、Hervé Pamingle
DOI:10.1002/ejoc.201403219
日期:2014.12
An economical and practicalsynthesis of rac-(Z)-β-santalol was accomplished. The key coupling step is based on a Scriabine-inspiredreaction of a dienyl diacetate substrate and an alkene. The total synthesis was achieved in five steps (longest linear sequence) in 19 % overall yield from cyclopentadiene.