3β-{2-[2-(2-aminoethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid | 1356007-62-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-{2-[2-(2-aminoethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid
• CAS: 1356007-62-9
• 化学式: C₃₆H₅₉NO₆
• 分子量: 601.868
• InChiKey: CLMWYCHJHUCSJJ-IGXJBCQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.78
• 重原子数：
  43.0
• 可旋转键数：
  9.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  108.08
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  3β-{2-[2-(2-aminoethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid 在 吡啶 、 tin(II) chloride dihdyrate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 25.5h， 生成 3β-{2-[2-(2-{4-[4-(5-{(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid
  参考文献：
  名称：

  Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid

  摘要：

  To explore the molecular mechanisms of oleanolic acid, two novel photoaffinity probes were synthesized based on the structure-activity relationship reported previously. Their potency were evaluated in an enzyme inhibition assay against rabbit muscle glycogen phosphorylase a (RMGPa), a known target protein of oleanolic acid. The inhibitory activity of probe 2 was only about two-fold less potent than the mother compound oleanolic acid. The photoaffinity labeling experiments were also performed and two proteins were specifically tagged by probe 2. The results suggest that the synthesized probes could be used as powerful tools to isolate and identify the target proteins of oleanolic acid. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.123
• 作为产物：
  描述：

  [2-(2-dibenzylaminoethoxy)ethoxy]acetic acid 在 氯化亚砜 、 palladium 10% on activated carbon 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 29.0h， 生成 3β-{2-[2-(2-aminoethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid
  参考文献：
  名称：

  Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid

  摘要：

  To explore the molecular mechanisms of oleanolic acid, two novel photoaffinity probes were synthesized based on the structure-activity relationship reported previously. Their potency were evaluated in an enzyme inhibition assay against rabbit muscle glycogen phosphorylase a (RMGPa), a known target protein of oleanolic acid. The inhibitory activity of probe 2 was only about two-fold less potent than the mother compound oleanolic acid. The photoaffinity labeling experiments were also performed and two proteins were specifically tagged by probe 2. The results suggest that the synthesized probes could be used as powerful tools to isolate and identify the target proteins of oleanolic acid. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.123