4-methyl-3-phenyl-6-(4-phenylbenzofuro[3,2-b]pyridin-2-yl)coumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 4-methyl-3-phenyl-6-(4-phenylbenzofuro[3,2-b]pyridin-2-yl)coumarin
• 英文别名: 4-Methyl-3-phenyl-6-(4-phenylbenzofuro[3,2-b]pyridin-2-yl)chromen-2-one；4-methyl-3-phenyl-6-(4-phenyl-[1]benzofuro[3,2-b]pyridin-2-yl)chromen-2-one
• 化学式: C₃₃H₂₁NO₃
• 分子量: 479.535
• InChiKey: BOAMDLWCQLFECF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2'-羟基查耳酮 在 吡啶 、 mercury(II) diacetate 、 ammonium acetate 、 溶剂黄146 作用下， 反应 12.25h， 生成 4-methyl-3-phenyl-6-(4-phenylbenzofuro[3,2-b]pyridin-2-yl)coumarin
  参考文献：
  名称：

  Modified Pyridine-Substituted Coumarins: A New Class of Antimicrobial and Antitubercular Agents

  摘要：

  Some new biologically potent coumarin derivatives 7a-f, 8a-f, and 9a-f bearing modified pyridine moieties (indeno[1,2-b]pyridine, 4-azaphenanthrene and benzofuro [3,2-b]pyridine) at the sixth position were designed and synthesized. All the synthesized compounds were assayed for their antimicrobial efficiency against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Candida albicans, and Aspergillus niger. Most of the compounds showed appreciable antimicrobial activity against the tested strains. Compounds 8b, 8c, 9b, 9d, and 9f emerged as most proficient members of the series. The antitubercular activity for all the synthesized compounds was performed against Mycobacterium tuberculosis H37R(v). Compounds 8f, 9b, and 9f exhibited promising antitubercular activity. Consequently, synthesized derivatives were found to be worthy of further investigation.

  DOI：

  10.1080/00397911.2014.963875

文献信息

• Modified Pyridine-Substituted Coumarins: A New Class of Antimicrobial and Antitubercular Agents
  作者：Rakesh R. Giri、Hemali B. Lad、Varun G. Bhila、Chirag V. Patel、D. I. Brahmbhatt

  DOI：10.1080/00397911.2014.963875

  日期：2015.2

  Some new biologically potent coumarin derivatives 7a-f, 8a-f, and 9a-f bearing modified pyridine moieties (indeno[1,2-b]pyridine, 4-azaphenanthrene and benzofuro [3,2-b]pyridine) at the sixth position were designed and synthesized. All the synthesized compounds were assayed for their antimicrobial efficiency against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Candida albicans, and Aspergillus niger. Most of the compounds showed appreciable antimicrobial activity against the tested strains. Compounds 8b, 8c, 9b, 9d, and 9f emerged as most proficient members of the series. The antitubercular activity for all the synthesized compounds was performed against Mycobacterium tuberculosis H37R(v). Compounds 8f, 9b, and 9f exhibited promising antitubercular activity. Consequently, synthesized derivatives were found to be worthy of further investigation.