3β-acetoxy-oleana-11,13(18)-diene | 2118-75-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-acetoxy-oleana-11,13(18)-diene
• 英文别名: oleana-11,13(18)-dien-3β-yl acetate；[(3S,4aR,6aR,6bS,8aR,14aR,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-yl] acetate
• CAS: 2118-75-4
• 化学式: C₃₂H₅₀O₂
• 分子量: 466.748
• InChiKey: HDOAIBGODBKXKL-LNFVHJCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  34
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3β-acetoxy-oleana-11,13(18)-diene 在 溶剂黄146 、 铂 作用下， 生成 乙酸-delta-香树精酯
  参考文献：
  名称：

  Zur Kenntnis der Triterpene。（62.米特隆）。环糊精β-糊精中的Einführungvon Doppelbindungen和Carbonylgruppen

  摘要：

  DOI：

  10.1002/hlca.194102401149
• 作为产物：
  描述：

  3β-Acetoxy-11β-hydroxy-olean-12-en 在 盐酸 、 溶剂黄146 作用下， 生成 3β-acetoxy-oleana-11,13(18)-diene
  参考文献：
  名称：

  Allan et al., Journal of the Chemical Society, 1954, p. 1546,1554

  摘要：

  DOI：

文献信息

• Triterpene dienols and other constituents from the bark of Phyllanthus flexuosus
  作者：Reiko Tanaka、Shunyo Matsunaga

  DOI：10.1016/0031-9422(88)80141-9

  日期：1988.1

  Abstract Besides four known triterpenes and bergenin, ent-3β-hydroxykaur-16-ene and two oleanadienols were isolated from the stem bark of Phyllanthus flexuosus. The bark also contained n-alkanes, n-alkanols and phytosterols.

  摘要 除了4种已知的三萜类化合物和bergenin外，从Phyllanthus flexuosus的茎皮中还分离到了ent-3β-hydroxykaur-16-ene和两种齐墩果二烯醇。树皮还含有正烷烃、正烷醇和植物甾醇。
• Beaton et al., Journal of the Chemical Society, 1955, p. 2616,2618
  作者：Beaton et al.

  DOI：——

  日期：——
• Zur Kenntnis der Triterpene. (62. Mitteilung). Einf�hrung von Doppelbindungen und Carbonylgruppen in die Ringe C?E des ?-Amyrins
  作者：L. Ruzicka、O. Jeger

  DOI：10.1002/hlca.194102401149

  日期：——
• Long-term glycemic control measurements in diabetic patients receiving hemodialysis
  作者：Melanie S. Joy、William T. Cefalu、Susan L. Hogan、Patrick H. Nachman

  DOI：10.1053/ajkd.2002.30549

  日期：2002.2

  Cardiovascular morbidity is increased in patients with diabetes mellitus and there is a great prevalence of diabetes and cardiovascular disease among patients with end-stage renal disease (ESRD). Control of glycemia can decrease cardiovascular and end-organ damage. Because the validity of glycemic control tests have not been rigorously studied in patients with ESRD, we evaluated the value of various measures in these patients. The overall clinical goal was to investigate whether hemoglobin A(1)C (A(1)C) accurately reflects actual glycemic control as compared with other measures in light of the importance of attaining appropriately controlled blood glucose (BG). The commonly used tests of total glycated hemoglobin (GHb) and A(1)C may be unreliable in patients with ESRD because of the presence of anemia, shortened red blood cell (RBC) survival, and assay interferences from uremia. The primary aim of this study was to assess the relationship of capillary BG measurements to A(1)C, GHb, total glycated plasma proteins (GPP), and fructosamine (Fr) in diabetic patients receiving hemodialysis. Twenty-three patients were instructed to obtain BG evaluations twice daily for 7 days by using the Elite glucometer (Bayer Corporation, Elkhart, IN). These determinations included 6 fasting, 6 preprandial, and 3 separate 2-hour postprandial levels. Blood was obtained on day 7 for measurement of A(1)C, GHb, GPP, and Fr. A(1)C was analyzed by an immunoassay, GPP and GHb were assayed by affinity high-performance liquid chromatography (HPLC), and Fr by automated nitroblue colorimetric assay. Scatter plots were generated by plotting the average BG versus A(1)C, GHb, GPP, or Fr. Linear regression was performed for each plot showing the following relationships: A(1)C = 0.0174 (BG) + 4.76 (r = 0.58; P < 0.05): GHb = 0.0371 (BG) + 3.57 (r = 0.584; P < 0.05): GPP = 0.0083 (BG) + 26.13 (r = 0.065; P = 0.77): Fr = 0.6865 (BG) + 250 (r = 0.345; P = 0.11). Despite anemia and shortened RBC lifespan in patients with ESRD, A(1)C in the range of 6% to 7% estimates glycemic control similarly to patients without severe renal impairment. A(1)C values above 7.5% may overestimate hyperglycemia in patients with ESRD. Thus, diabetic patients receiving hemodialysis may have long-term BG that are more properly controlled than previously determined, reducing their risks of the macro- and microvascular complications of diabetes mellitus. (C) 2002 by the National Kidney Foundation, Inc.
• 145. Triterpene resinols and related acids. Part XVIII. The conversion of β-amyratrienyl acetate into β-amyradiendionyl acetate
  作者：G. T. Newbold、F. S. Spring

  DOI：10.1039/jr9440000532

  日期：——