The present invention regards compositions and methods for the modulation of amidases capable of hydrolysing N-acylethanolamines useable in the therapy of inflammatory diseases. In particular, the present invention regards a compound of general formula (I): enantiomers, diastereoisomers, racemes and mixtures, polymorphs, salts, solvates thereof, wherein: (a) R is a linear alkyl radical having 13 to 19 carbon atoms or alkenyl radical having 13 to 19 carbon atoms carrying a double bond; (b) X is 0 or S; (c) Y is a 2 or 3 carbon atom alkylene residue, optionally substituted with one or two groups equal or different from each other and selected from among the group consisting of: —CH
3
, —CH
2
OH, —COOCH
3
, —COOH. Y may preferably be: —CH
2
—CH
2
—, —CH
2
—CH
2
—CH
2
—, CH(CH
3
)—CH
2
—, —CH
2
—CH(CH
3
)—, —CH
2
—C(CH
3
)
2
—, —CH
2
—CH(CH
2
OH)—, —CH
2
—C((CH
2
OH)
2
)—, —CH═CH—, —CH
2
—CH(COOCH
3
)—, —CH
2
—CH(COOH)—, for use as a medicine.
本发明涉及用于调节能够
水解N-酰
乙醇胺的酰胺酶的组合物和方法,用于治疗炎症性疾病。具体来说,本发明涉及一般式(I)的化合物:对映体、非对映异构体、消旋体和混合物、多形态、盐、溶剂化合物,其中:(a) R是具有13至19个碳原子的直链烷基基团或具有13至19个碳原子并带有一个双键的烯基基团;(b) X为0或S;(c) Y为2或3个碳原子的烷基烃基残基,可选择地取代一个或两个相等或不同的基团,所述基团选自以下群组中的一种:—
CH3、— OH、—COO 、—COOH。Y可能更倾向于是:—
CH2— —、— — — —、CH( )— —、— —CH( )—、— —C( )2—、— —CH( OH)—、— —C(( OH)2—、—CH═CH—、— —CH(COO )—、— —CH(COOH)—,用作药物。