Benzyl-carbamic acid (6Z,11Z)-(1S,2R,3R,4S,8S,9S,10S,13S)-3,9,13-tris-(tert-butyl-dimethyl-silanyloxy)-14-((2S,3R)-3,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-2,4,6,8,10-pentamethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-tetradeca-6,11-dienyl ester | 835929-68-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Benzyl-carbamic acid (6Z,11Z)-(1S,2R,3R,4S,8S,9S,10S,13S)-3,9,13-tris-(tert-butyl-dimethyl-silanyloxy)-14-((2S,3R)-3,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-2,4,6,8,10-pentamethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-tetradeca-6,11-dienyl ester
• CAS: 835929-68-5
• 化学式: C₅₈H₁₀₁NO₇Si₃
• 分子量: 1008.7
• InChiKey: QBJRVMCRMCCCLA-IJGVPBFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.17
• 重原子数：
  69.0
• 可旋转键数：
  24.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  92.32
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  Benzyl-carbamic acid (6Z,11Z)-(1S,2R,3R,4S,8S,9S,10S,13S)-3,9,13-tris-(tert-butyl-dimethyl-silanyloxy)-14-((2S,3R)-3,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-2,4,6,8,10-pentamethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-tetradeca-6,11-dienyl ester 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以67%的产率得到Benzyl-carbamic acid (6Z,11Z)-(1S,2S,3R,4S,8S,9S,10S,13S)-14-((2S,3R)-3,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3,9,13-trihydroxy-2,4,6,8,10-pentamethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-tetradeca-6,11-dienyl ester
  参考文献：
  名称：

  Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide

  摘要：

  The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule-stabilizing agent (divided by)-discodermolide (1) have been achieved. Structure-activity relationships of the C(19) carbamate were defined. exploiting two synthetically simplified scaffolds. as well as the parent (+)-discodermolide framework.

  DOI：

  10.1021/ol047686a
• 作为产物：
  描述：

  (S)-3-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)butanal 在 (4,5-dihydroIMES)(PCy₃)Cl₂Ru=CHPh 4-二甲氨基吡啶 、 正丁基锂 、 potassium tert-butylate 、 水 、 甲基锂 、 碳酸氢钠 、 戴斯-马丁氧化剂 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 、 lithium bromide 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 正戊烷 为溶剂， 反应 13.66h， 生成 Benzyl-carbamic acid (6Z,11Z)-(1S,2R,3R,4S,8S,9S,10S,13S)-3,9,13-tris-(tert-butyl-dimethyl-silanyloxy)-14-((2S,3R)-3,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-2,4,6,8,10-pentamethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-tetradeca-6,11-dienyl ester
  参考文献：
  名称：

  Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide

  摘要：

  The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule-stabilizing agent (divided by)-discodermolide (1) have been achieved. Structure-activity relationships of the C(19) carbamate were defined. exploiting two synthetically simplified scaffolds. as well as the parent (+)-discodermolide framework.

  DOI：

  10.1021/ol047686a