(S)-4-(2-吡咯烷基甲基)吗啉 | 91790-91-9

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: (S)-4-(2-吡咯烷基甲基)吗啉
• 中文别名: 4-[(2S)-吡咯烷甲基]吗啉
• 英文名称: (S)-4-[(2-pyrrolidinyl)methyl]morpholine
• 英文别名: (S)-2-(morpholin-4-ylmethyl)-pyrrolidine；(S)-2-(1-morpholinylmethyl)pyrrolidine；(S)-2-(morpholinomethyl) pyrrolidine；(S)-2-(morpholinomethyl)pyrrolidine；2-(S)-(morpholinomethyl)pyrrolidine；(S)-4-pyrrolidin-2-ylmethyl-morpholine；(S)-4-(pyrrolidin-2-ylmethyl)morpholine；4-[[(2S)-pyrrolidin-2-yl]methyl]morpholine
• CAS: 91790-91-9
• 化学式: C₉H₁₈N₂O
• mdl: MFCD09723403
• 分子量: 170.255
• InChiKey: UUUSROHBEMVRKP-VIFPVBQESA-N

物化性质

• 沸点：
  255℃
• 密度：
  1.019
• 闪点：
  108℃

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-4-(2-吡咯烷基甲基)吗啉 在 六氟异丙醇 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.5h， 生成 C-morpholin-4-yl-C-(2-(morpholin-4-ylmethyl)pyrrolidin-1-yl)-methylenamine
  参考文献：
  名称：

  Synthesis of hindered chiral guanidine bases starting from (S)-(N,N-dialkyl-aminomethyl)pyrrolidines and BrCN

  摘要：

  An efficient method for the preparation of hindered chiral quanidines using cyanogen bromide is described. The reaction between BrCN and vicinal diamines derived from (S)-2-(N,N-dialkyl-amiilomethyl)-pyrrolidines provides chiral substituted cyanamides. The cyanamide derivatives reacted with secondary amines in hexafluoroisopropanol at reflux to form chiral hindered guanidines, which were isolated in good to excellent yields (70-96%). The chiral guanidines were prepared in an effort to design sophisticated chiral guanidine catalysts for asymmetric synthesis. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.02.009
• 作为产物：
  描述：

  N-苄氧羰基-L-脯氨酸 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 (S)-4-(2-吡咯烷基甲基)吗啉
  参考文献：
  名称：

  Asymmetric Trasformation of Symmetrical Epoxides to Allylic Alcohols by Lithium (S)-2-(N,N-Disubstituted aminomethyl)pyrrolidide

  摘要：

  使用由(S)-2-(N,N-二取代氨基甲基)吡咯烷和丁基锂制备的手性锂胺，研究了对称环氧化物的对映选择性去质子化反应。通过在四氢呋喃（THF）中采用锂(S)-2-(1-吡咯啉甲基)吡咯化锂并加入1,8-二氮杂双环[5.4.0]十一碳-7-烯（DBU）的条件，从若干环状和非环状环氧化物中获得了具有中等至高度对映体过剩（ee's）（41-92% ee）的手性烯丙醇。

  DOI：

  10.1246/bcsj.63.721
• 作为试剂：
  描述：

  syn-4-(tert-butyldimethylsilyloxy)cyclopentene oxide 在 正丁基锂 、 (S)-4-(2-吡咯烷基甲基)吗啉 作用下， 生成 2-环戊烯-1-醇,4-[[(1,1-二甲基乙基)二甲基甲硅烷基]氧代]-,(1R,4S)- 、 2-环戊烯-1-醇,4-[[(1,1-二甲基乙基)二甲基甲硅烷基]氧代]-,(1S,4R)-
  参考文献：
  名称：

  顺式-4-叔丁基二甲基甲硅烷氧基-2-环戊烯-1-醇和顺式-4-四氢吡喃氧基-2-环戊烯-1-醇的不对称合成

  摘要：

  通过顺式-3,4-环氧环戊烷-的反应，以高对映体过量（ee）获得顺式-4-叔丁基二甲基甲硅烷氧基-2-环戊烯-1-醇和顺式-4-四氢吡喃氧基-2-环戊烯-1-醇。具有手性锂酰胺的1-ol衍生物。证明了在（S）-和（R）-4-羟基-2-环戊烯酮的合成中的应用。

  DOI：

  10.1016/s0040-4039(00)98931-7

文献信息

• CATALYST FOR ASYMMETRIC HYDROGENATION
  申请人：MAEDA Hironori

  公开号：US20100324338A1

  公开（公告）日：2010-12-23

  This invention aims at providing a catalyst for producing an optically active aldehyde or an optically active ketone, which is an optically active carbonyl compound, by carrying out selective asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, particularly a catalyst which is insoluble in a reaction mixture for obtaining optically active citronellal which is useful as a flavor or fragrance, by carrying out selective asymmetric hydrogenation of citral, geranial or neral; and a method for producing a corresponding optically active carbonyl compound. The invention relates to a catalyst for asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, which comprises a powder of at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table, or a metal-supported substance in which at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table is supported on a support, an optically active cyclic nitrogen-containing compound and an acid.

  这项发明旨在通过对α，β-不饱和羰基化合物进行选择性不对称加氢，特别是通过对柠檬醛、香叶醛或柠檬醛进行选择性不对称加氢，从而提供用作香料或香精的有用的光学活性香茅醛的催化剂，该香茅醛是一种光学活性羰基化合物；以及生产相应的光学活性羰基化合物的方法。该发明涉及一种用于不对称加氢α，β-不饱和羰基化合物的催化剂，其包括来自周期表第8至第10族金属中至少一种金属的粉末，或者至少一种来自周期表第8至第10族金属的金属负载物质，该金属负载在一种支撑物上，还包括光学活性的含氮环化合物和酸。
• Condensed diazepinones, their compositions and methods of use as
  申请人：Dr. Karl Thomae GmbH

  公开号：US04550107A1

  公开（公告）日：1985-10-29

  Disclosed are novel condensed diazepinones of formula I ##STR1## wherein B is a fused ring selected from ##STR2## X is --CH-- or, when B is ortho-phenylene, X can also be nitrogen; A.sub.1 is C.sub.1 -C.sub.2 alkylene; A.sub.2 is C.sub.1 -C.sub.2 when it is in the 2-position relative to the saturated heterocyclic ring nitrogen or a single bond or methylene when it is in the 3- or 4-position; R.sub.1 is C.sub.1 -C.sub.3 alkyl; R.sub.2 is C.sub.1 -C.sub.7 alkyl, optionally hydroxy-substituted on at least one of its second to seventh carbon, or C.sub.3 -C.sub.7 cycloalkyl, optionally hydroxy substituted, or C.sub.3 -C.sub.7 cycloalkylmethyl; or R.sub.1 and R.sub.2 can, together with the nitrogen therebetween, be a 4- to 7-membered saturated monocyclic, heterocyclic ring which can optionally include an oxygen or N--CH.sub.3 ; R.sub.3 is hydrogen, chlorine, or methyl; R.sub.4 is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.5 is hydrogen, chlorine or C.sub.1 -C.sub.4 alkyl; and Z is a single bond, oxygen, methylene or 1,2-ethylene; and NR.sub.1 R.sub.2 --N oxides and nontoxic, pharmaceutically acceptable addition salts thereof. Also disclosed are pyrrolobenzodiazepinone intermediates, pharmaceutical compositions containing the condensed diazepinones and methods of using them to treat cardiovascular disorders, particularly bradycardia and bradyarrhythmia.

  揭示了式I的新型缩合二氮杂环酮##STR1##其中B是从##STR2##中选择的融合环；X是--CH--或者当B是邻苯二甲烷时，X也可以是氮；A.sub.1是C.sub.1-C.sub.2烷基；A.sub.2是C.sub.1-C.sub.2，当它相对于饱和杂环环氮位于2位时，或者是单键或亚甲基，当它位于3位或4位时；R.sub.1是C.sub.1-C.sub.3烷基；R.sub.2是C.sub.1-C.sub.7烷基，其至少在第二到第七碳上可选择地被羟基取代，或者是C.sub.3-C.sub.7环烷基，可选择地被羟基取代，或者是C.sub.3-C.sub.7环烷基甲基；或者R.sub.1和R.sub.2可以与其之间的氮一起形成一个4到7成员的饱和单环杂环，可选择地包括氧或N--CH.sub.3；R.sub.3是氢、氯或甲基；R.sub.4是氢或C.sub.1-C.sub.4烷基，R.sub.5是氢、氯或C.sub.1-C.sub.4烷基；Z是单键、氧、亚甲基或1,2-乙烯基；以及NR.sub.1 R.sub.2 --N氧化物和其无毒、药学上可接受的加合盐。还揭示了吡咯苯二氮杂环酮中间体、含有缩合二氮杂环酮的药物组合物以及使用它们治疗心血管疾病，特别是心动过缓和心动过缓性心律失常的方法。
• Sulfonamide lactam inhibitors of FXa and method
  申请人：——

  公开号：US20040186134A1

  公开（公告）日：2004-09-23

  Sulfonamide lactams of the following formula 1 wherein X, R 1 , R 2 , R 3 , R 4 , R 4a , R 5 , R 5a , R 6 , R 6a , R 7 and R 8 are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.

  以下式子中的磺胺酰胺内酰胺，其中X、R1、R2、R3、R4、R4a、R5、R5a、R6、R6a、R7和R8如本文所述，被提供为因子Xa的抑制剂，并且在治疗与血栓相关的心血管疾病中作为抗凝剂是有用的。
• [EN] NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS D'AMIDE SUBSTITUÉS BÉTULINIQUES UTILISÉS COMME INHIBITEURS DU VIH
  申请人：HETERO RESEARCH FOUNDATION

  公开号：WO2017017630A1

  公开（公告）日：2017-02-02

  The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

  本发明涉及新的取代苦杏仁酸酰胺化合物的化学式(I)；以及其药用盐，其中R1、R2、R3、R4、R5、R6、R7、R8、X、Y、Z1、Z2、Z3和在此定义的化学式(II)。该发明涉及新的取代苦杏仁酸酰胺衍生物、相关化合物和药物组合物，用于治疗病毒性疾病，特别是HIV介导的疾病。
• Thiophene derivatives useful as anticancer agents
  申请人：——

  公开号：US20020042409A1

  公开（公告）日：2002-04-11

  The invention relates to compounds of the formula 1 1 or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R 1 , R 2 and R 11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

  该发明涉及公式11的化合物或其药用可接受盐，以及其药用可接受盐和水合物，其中X、Y、R1、R2和R11如本文所定义。该发明还涉及含有公式1化合物的药物组合物，以及通过给哺乳动物施用公式1化合物来治疗过度增殖性疾病的方法。