2,2'-bis(diphenylphosphino)propane | 57585-26-9

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-bis(diphenylphosphino)propane
• 英文别名: Phosphine, (1-methylethylidene)bis[diphenyl-；2-diphenylphosphanylpropan-2-yl(diphenyl)phosphane
• CAS: 57585-26-9
• 化学式: C₂₇H₂₆P₂
• 分子量: 412.451
• InChiKey: LRLQQERNMXHASR-UHFFFAOYSA-N

物化性质

• 熔点：
  123-123.5 °C
• 沸点：
  512.0±33.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,2'-bis(diphenylphosphino)propane 在 CO 作用下， 以 丙酮 为溶剂， 生成 [RhBr(CO)(2,2-bis(diphenylphosphino)propane)]
  参考文献：
  名称：

  Four-membered chelate rings in complexes with 2,2-bis(diphenylphosphino)propane. Crystal and molecular structures of trans-[RuCl₂{Me₂C(PPh₂)₂}₂], [RuCl{Me₂C(PPh₂)₂}(η-C₅H₅)] and [(η-C₅H₅)Ru(µ-CO)₂-{µ-Me₂C(PPh₂)₂}RhCl₂](Rh–Ru)

  摘要：

  The compound Me(2)C(PPh(2))(2) (2,2-dppp) reacted with 0.5 equivalent of [Rh2Cl2(CO)(4)] to afford monomeric [RhCl(CO)(2.2-dppp-P,P')] 1. Metathesis with LiBr afforded [RhBr(CO)(2.2-dppp-P,P')] 2. With 0.25 equivalent of [Rh2Cl2(CO)(4)] the rigid, square-planar [Rh(2,2-dppm)(2)]Cl 3 was formed. These results are in sharp contrast to the chemistry seen with H2C(PPh(2))(2) and H(Me)C(PPh(2))(2). With 0.5 equivalent of [RuCl2(PPh(3))(3)], 2,2-dppp reacted to give brown-orange trans-[RuCl2(2,2-dppp)(2)] 4a. In solution this is in equilibrium with a green five-co-ordinate species [RuCl(2,2-dppp)(2)]Cl 4b, the first such complex to be observed with a four-membered chelating diphosphine. With [RuCl(PPh(3))(2)(eta-C5H5)], 2,2-dppp reacted to form [RuCl(2,2-dppp)(eta-C5H5)] 5. Although its rhodium(I) chemistry suggests that 2,2-dppp favours chelation rather than bridging modes of co-ordination, when 5 was treated with 0.5 equivalent of [Rh2Cl2(CO)(4)] it readily formed [(eta-C5H5)Ru(mu-Co)(2)(mu-2,2-dppp)RhCl2](Rh-Ru) 6. The structures of 4-6 have been determined by X-ray diffraction.

  DOI：

  10.1039/dt9950002901
• 作为产物：
  描述：

  2,2-二氯丙烷 、 二苯基膦酸锂 以 四氢呋喃 为溶剂， 以39%的产率得到2,2'-bis(diphenylphosphino)propane
  参考文献：
  名称：

  Backbone modified small bite-angle diphosphines: Synthesis and molecular structures of [M(CO)4{X2PC(R1R2)PX2}] (M=Mo, W; X=Ph, Cy; R1=H, Me, Et, Pr, allyl, R2=Me, allyl)

  摘要：

  A range of new small bite-angle diphosphine complexes, [M(CO)(4) {X2PC((RR2)-R-1)PX2}] (M = Mo, W; X = Ph, Cy; R-1 = H, Me, Et, Pr, allyl, R 2 = Me, allyl), have been prepared via elaboration of the methylene backbones in [M(CO)(4)(X2PCH2PX2)] as a result of successive deprotonation and alkyl halide addition. When X = Ph it proved possible to replace both methylene protons but for X = Cy only one substitution proved possible. This is likely due to the electron-releasing nature of the cyclohexyl groups but may also be due to steric constraints. Attempts to prepare the bis(allyl) substituted complex [Mo(CO)(4){Ph2PC(allyl)(2)PPh2}] were only moderately successful. The crystal structures of nine of these complexes are presented. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2007.09.024
• 作为试剂：
  描述：

  4-溴-2-甲基苯甲酸甲酯 、 三乙胺 、 水 、 一氧化碳 、 乙酸乙酯 在 醋酸钯 、 2,2'-bis(diphenylphosphino)propane 水 、 乙酸乙酯 、 magnesium sulfate 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以to give 2-methylbenzene-1,4-dicarboxylic acid 1-methyl ester (16.57 g, 87%) as a white solid, mp 134-136° C.的产率得到4-(甲氧甲酰基)-3-甲基苯甲酸
  参考文献：
  名称：

  Diaminopropionic acid derivatives

  摘要：

  一种用于治疗再灌注损伤的化合物，其化学式为1a，以及其盐、前药和相关化合物。

  公开号：

  US20050080119A1

文献信息

• [EN] VIRAL POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS DE POLYMERASE VIRALE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2004065367A1

  公开（公告）日：2004-08-05

  An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.

  化合物的异构体、对映体、非对映异构体或互变异构体，由式(I)所代表：其中A、B、R2、R3、L、M1、M2、M3、M4、Y1、Y0、Z和Sp如权利要求1中定义，或其盐，作为HCV NS5B聚合酶的抑制剂。
• [EN] SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS<br/>[FR] COMPOSÉS TÉTRAHYDROISOQUINOLINES SUBSTITUÉS EN TANT QU'INHIBITEURS DU FACTEUR XIA
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2013055984A1

  公开（公告）日：2013-04-18

  The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

  本发明提供了化合物的公式(I)：或其立体异构体，以及其药学上可接受的盐，其中所有变量如本文所定义。这些化合物是XIa因子和/或血浆激肽酶的抑制剂，可用作药物。
• [EN] NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS<br/>[FR] NOUVEAUX MACROCYCLES EN TANT QU'INHIBITEURS DU FACTEUR XIA
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2013022818A1

  公开（公告）日：2013-02-14

  The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

  本发明提供了化合物的公式(Ia)：或其立体异构体、互变异构体或药用可接受盐，其中所有变量如本文所定义。这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽原的双重抑制剂。本发明还涉及包含这些化合物的药物组合物以及使用它们治疗血栓栓塞和/或炎症性疾病的方法。
• [EN] ISOQUINOLINES AS POTASSIUM ION CHANNEL INHIBITORS<br/>[FR] ISOQUINOLINES SERVANT D'INHIBITEURS DES CANAUX IONIQUES POTASSIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014143609A1

  公开（公告）日：2014-09-18

  A compound of formula (I) (I) wherein A, R1, R1a, R3 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

  式（I）的化合物，其中A、R1、R1a、R3和R24如本文所述。这些化合物可用作钾通道功能的抑制剂，用于治疗和预防心律失常、IKur相关疾病以及其他由离子通道功能介导的疾病。
• [EN] ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS<br/>[FR] ACIDES ISOXAZOLE CARBOXYLIQUES EN TANT QU'ANTAGONISTES DE LPA
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2020257138A1

  公开（公告）日：2020-12-24

  The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

  本发明提供了式（I）的化合物或其立体异构体、互变异构体或药学上可接受的盐或溶剂，其中所有变量如本文所定义。这些化合物是选择性LPA受体抑制剂。