5-deoxy-3'-prenylbiochanin A

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 5-deoxy-3'-prenylbiochanin A
• 英文别名: 7-Hydroxy-4'-methoxy-3'-prenylisoflavone；7-hydroxy-3-[4-methoxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one
• 化学式: C₂₁H₂₀O₄
• 分子量: 336.387
• InChiKey: RUCMCGSYMSEMIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-deoxy-3'-prenylbiochanin A 、 氢碘酸 生成 新补骨脂异黄酮
  参考文献：
  名称：

  SAXENA, V. K.;BHADORIA, B. K., J. NATUR. PROD., 53,(1990) N, C. 62-65

  摘要：

  DOI：
• 作为产物：
  描述：

  3-烯丙基-4-甲氧基-苯甲醛 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 硫酸 、 sodium acetate 、 potassium hydroxide 、 原甲酸三甲酯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 170.08h， 生成 5-deoxy-3'-prenylbiochanin A
  参考文献：
  名称：

  Erythrina sacleuxii 异黄酮的全合成及其抗菌活性：5-Deoxy-3'-prenylbiochanin A 和 Erysubin F

  摘要：

  首次合成了异黄酮 5-deoxyprenylbiochanin A (7-hydroxy-4'-methoxy-3'-prenylisoflavone) 和 erysubin F (7,4'-dihydroxy-8,3'-diprenylisoflavone)。 - 或二-O-烯丙基化查耳酮，5-脱氧-3'-异戊二烯生物链素A的结构通过单晶X射线衍射分析得到证实。黄烷酮是合成中的关键中间体。它们与高价碘试剂反应通过 2,3-氧化重排得到异黄酮，通过 2,3-脱氢得到相应的黄酮异构体。这使得合成 7,4'-二羟基-8,3'-二异戊二烯黄酮，一种赤霉素 F 的非天然区域异构体。 Erysubin F ( 8 ), 7,4'-二羟基-8,3'-二异戊二烯黄酮 ( 27 ) , 和 5-deoxy-3'-prenylbiochanin A (7 ) 针对三种细菌菌株和一种真菌病原体进行了测试。所有

  DOI：

  10.1021/acs.jnatprod.0c00932

文献信息

• COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS
  申请人：Miller Freda

  公开号：US20110301105A1

  公开（公告）日：2011-12-08

  We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.
• US8748177B2
  申请人：——

  公开号：US8748177B2

  公开（公告）日：2014-06-10
• [EN] COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS<br/>[FR] COMPOSITIONS POUR LA PROLIFÉRATION DE CELLULES ET PROCÉDÉS ASSOCIÉS
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2010039679A1

  公开（公告）日：2010-04-08

  We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.