2-(3’,7’,11’-trimethyldodecyloxy)-9-phenylfluoren-9-ol | 1363340-12-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(3’,7’,11’-trimethyldodecyloxy)-9-phenylfluoren-9-ol
• 英文别名: 2-(3,7,11-trimethyldodecyloxy)-9-phenylfluoren-9-ol；2-(3',7',11'-Trimethyldodecyloxy)-9-phenylfluoren-9-ol；9-phenyl-2-(3,7,11-trimethyldodecoxy)fluoren-9-ol
• CAS: 1363340-12-8
• 化学式: C₃₄H₄₄O₂
• 分子量: 484.722
• InChiKey: DLRYDEXZOMPUQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3’,7’,11’-trimethyldodecyloxy)-9-phenylfluoren-9-ol 在 乙酰溴 作用下， 以 氯仿 为溶剂， 反应 6.0h， 以62%的产率得到2-(3',7',11'-trimethyldodecyloxy)-9-bromo-9-phenylfluorene
  参考文献：
  名称：

  AROMATIC COMPOUND CONTAINING SPECIFIC BRANCH

  摘要：

  公开号：

  EP2612845B1
• 作为产物：
  描述：

  金合欢醇 在 硫酸 、 2 % platinum on carbon 、 氢溴酸 、 氢气 、 碘 、 potassium carbonate 、 magnesium 作用下， 以 四氢呋喃 、 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 2-(3’,7’,11’-trimethyldodecyloxy)-9-phenylfluoren-9-ol
  参考文献：
  名称：

  AROMATIC COMPOUND CONTAINING SPECIFIC BRANCH

  摘要：

  公开号：

  EP2612845B1

文献信息

• BRANCHED CHAIN-CONTAINING AROMATIC COMPOUND
  申请人：TAKAHASHI Daisuke

  公开号：US20120059149A1

  公开（公告）日：2012-03-08

  [Summary] [Problem] Provision of a novel compound which is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, that provides a final product simply by extraction-layer-separating, without crystallization and isolation of each intermediate in each step. [Solving Means] It has been found that the above-mentioned problems can be solved by a particular branched chain-containing aromatic compound.

  提供一种新化合物，该化合物在异丙醇醋酸酯中易溶，优于液体分离操作性，并可用于肽等物质的生产方法，通过提取层分离即可得到最终产品，无需在每个步骤中结晶和分离每个中间体。已发现可以通过特定的含支链芳香化合物解决上述问题。
• METHOD FOR REMOVING FMOC GROUP
  申请人：Ajinomoto Co., Inc.

  公开号：US20140296483A1

  公开（公告）日：2014-10-02

  The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I): HS-L-COOH  (I) wherein L is a C 1-8 alkylene group optionally having substituent(s), an amino group-containing compound protected by an Fmoc group, and a base to give a reaction mixture containing a compound represented by the formula (II): Fm-S-L-COOH  (II) wherein Fm is a 9-fluorenylmethyl group, and L is as mentioned above, and an amino group-containing compound, and a step of removing the compound represented by the formula (II) by washing the obtained reaction mixture with a basic aqueous solution. According to the present invention, a removal method of Fmoc group, which can remove a dibenzofulvene derivative as a byproduct with ease, can be provided.

  本发明涉及一种去除Fmoc基团的方法，包括混合式化合物（I）的步骤：HS-L-COOH（I），其中L是一个C1-8烷基链，可选地具有取代基，一种被Fmoc基团保护的氨基化合物和一种碱，以得到一种反应混合物，其中包含一种化合物，其由式（II）表示：Fm-S-L-COOH（II），其中Fm是9-芴甲基基团，L如上所述，还包括一种氨基化合物，以及通过用碱性水溶液洗涤所得到的反应混合物，去除由式（II）表示的化合物。根据本发明，可以提供一种可以轻松去除二苯并富烯衍生物作为副产物的Fmoc基团去除方法。
• Branched chain-containing aromatic compound
  申请人：Takahashi Daisuke

  公开号：US08546534B2

  公开（公告）日：2013-10-01

  The present invention provides a particular branched chain-containing aromatic compound. The branched chain-containing aromatic compound of the present invention is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, which provides a final product simply by extraction separation, without crystallization and isolation of each intermediate in each step.

  本发明提供了一种特定的含有支链的芳香化合物。本发明的含有支链的芳香化合物在异丙醯基乙酸中易溶，具有优异的液体分离操作性能，可用于肽等的生产方法，通过提取分离即可提供最终产品，无需在每个步骤中结晶和分离每个中间体。
• METHOD FOR PRODUCING CYCLIZED PEPTIDE HAVING INTRAMOLECULAR S-S BOND
  申请人：AJINOMOTO CO., INC.

  公开号：EP3882255A1

  公开（公告）日：2021-09-22

  The present invention provides a method for producing a cyclized peptide having a crosslinked structure by one or more intramolecular S-S bonds, which is shown below. A method for producing a cyclized peptide, including (1-A) as to a linear peptide having two or more SH groups as functional groups on the peptide, in which all SH groups are protected, an N terminal amino group is optionally protected, and all of a C-terminal carboxy group and other functional groups on the peptide are protected (completely-protected peptide), a step of removing protecting groups of all functional groups other than the protected SH groups in the peptide, (1-B) a step of protecting all SH groups of the linear peptide having two or more SH groups as the functional groups on the peptide by forming a temporary S-S bond, and (2) a step of subjecting the peptide obtained by the above-mentioned step (1-A) and step (1-B), in which two or more SH groups are present as the functional groups on the peptide, all SH groups are protected by formation of a temporary S-S bond, and all protecting groups of other functional groups on the peptide are removed (S-protected peptide) to a folding step under oxidation and reduction conditions to obtain the cyclized peptide by re-forming an S-S bond in the peptide molecule.

  本发明提供了一种通过一个或多个分子内 S-S 键交联结构的环化肽的生产方法，如下所示。 一种生产环化肽的方法，包括 (1-A) 对于肽上具有两个或两个以上 SH 基团作为官能团的线性肽，其中所有 SH 基团均受保护，N 端氨基任选受保护，C 端羧基和肽上的其他官能团均受保护（完全保护肽），去除肽中除受保护的 SH 基团以外的所有官能团的保护基团的步骤、 (1-B) 通过形成临时的 S-S 键来保护多肽上具有两个或两个以上 SH 基团的线性多肽的所有 SH 基团、 和 (2) 将上述步骤（1-A）和步骤（1-B）得到的多肽（其中有两个或两个以上的 SH 基团作为多肽上的官能团，通过形成临时 S-S 键保护所有 SH 基团，并去除多肽上其他官能团的所有保护基团（S 保护多肽））在氧化和还原条件下进行折叠步骤，通过在多肽分子中重新形成 S-S 键得到环化多肽。
• METHOD FOR PRODUCING PEPTIDE CONTINUOUSLY
  申请人：AJINOMOTO CO., INC.

  公开号：US20220041648A1

  公开（公告）日：2022-02-10

  Peptides may be continuously produced by a method including the following steps (1), (A), (2), and (B): (1) performing a condensation reaction in a flow reactor to obtain an N-protected C-protected peptide in which an N-terminal amino group and C-terminal are protected by protecting groups, a side chain functional group is optionally further protected by a protecting group, and at least one of the C-terminal or the side chain functional group is protected by a pseudo-solid-phase protecting group (N-protected C-protected peptide), (A) washing a reaction mixture containing an N-protected C-protected peptide in a flow reactor and separating oil and water to separate an organic layer containing the N-protected C-protected peptide, (2) subjecting an organic layer containing an N-protected C-protected peptide to a reaction to remove a protecting group of an N-terminal amino group in a flow reactor to obtain a C-protected peptide in which an N-terminal amino group is not protected, C-terminal is protected by a protecting group, a side chain functional group is optionally further protected by a protecting group, and at least one of the C-terminal or the side chain functional group is protected by a pseudo-solid-phase protecting group (N-unprotected C-protected peptide), (B) subjecting a reaction mixture containing an N-unprotected C-protected peptide to washing and oil-water separation in a flow reactor to separate an organic layer containing the N-unprotected C-protected peptide.