Diphenyldichlorosilane is a colorless liquid with a pungent odor. It will burn though it may require some effort to ignite. It is decomposed by water to hydrochloric acid with evolution of heat. It is corrosive to metals and tissue.
颜色/状态:
Colorless liquid
气味:
SHARP, HYDROCHLORIC ACID-LIKE; PUNGENT
蒸汽密度:
8.45 (Air = 1)
分解:
The silanes decomp at elevated temp to liberate hydrogen and deposit a high purity silicon, which leads to some of the principal uses of silanes. /Silanes/
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Silane, Chlorosilane, and Related Compounds/
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/
/SIGNS AND SYMPTOMS/ Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Higher exposure can cause pulmonary edema, a medical emergency that can be delayed for several hours. This can cause death. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. If the eyes have come in contact with dimethyldichlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure. Inhalation irritates mucous membranes. Severe gastrointestinal damage may occur. Vapors cause severe eye and lung injury. Upon short contact, second and third degree burns may occur. Signs and symptoms of acute ingestion of dimethyldichlorosilane may be severe and include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. /Dimethyldichlorosilane/
Syntheses and structures of (N′,N′-dimethylhydrazido)silanes
作者:Ingo Gronde、Beate Neumann、Alexander Willner、Tania Pape、Norbert W. Mitzel
DOI:10.1039/b900293f
日期:——
The hydrazidosilanes Ph2Si(NHNMe2)2 (1), Me2Si(NHNMe2)2 (2), PhSi(NHNMe2)3 (3), MeSi(NHNMe2)3 (4), PhClSi(NHNMe2)2 (5), MeClSi(NHNMe2)2 (6), Me2ClSi(NHNMe2) (7), MeClHSi(NHNMe2) (8), MeHSi(NHNMe2)2 (9), Me2HSi(NHNMe2) (10), Me2NN[HSi(NHNMe2)2]2 (11) and Si(NHNMe2)4 (12) have been prepared by the reaction of the corresponding chlorosilanes with N,N-dimethylhydrazine. Some of the compounds containing SiâCl and NâH functions simultaneously (6, 7, 8) are very reactive and tend to polymerise and could only be characterised by spectroscopic methods (1H, 13C, 29Si NMR, IR, MS). All other compounds could additionally be characterised by elemental analyses. The structures of 1, 2, 5, 9, 11 and 12 in the solid state were determined by X-ray diffraction. These include the first structural determinations of compounds containing SiHâNHâN (9, 11) and SiClâNHâN (5) units.
Bisaryldithiophosphonic Acids: Synthesis and Their Reactions with Organyl Chlorosilanes, Germanes, Stannanes, and Plumbanes
作者:Il'yas S. Nizamov、Gulnara T. Gabdullina、Ilnar D. Nizamov、Yevgeniy N. Nikitin、Lyubov A. Al'metkina、Rafael A. Cherkasov
DOI:10.1080/10426500902930142
日期:2010.3.24
A method of synthesizing arylbisdithiophosphonic acids was developed by the reaction of 2,4-diaryl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with tri(ethylene glycol) and 1,4-butandiol in anhydrous benzene suspension under mild conditions. The arylbisdithiophosphonic acids thus obtained were transformed into the corresponding diammonium salts. New bis(triorganylgermyl), stannyl and plumbyl, and cyclic
Cross-Coupling of Triallyl(aryl)silanes with Aryl Bromides and Chlorides: An Alternative Convenient Biaryl Synthesis
作者:Akhila K. Sahoo、Takuro Oda、Yoshiaki Nakao、Tamejiro Hiyama
DOI:10.1002/adsc.200404188
日期:2004.12
give various biaryls in good yields. It is worthwhile to note that the all-carbon-substituted arylsilanes, stable towards moisture, acid, and base and easily accessible, serve as a highly practical alternative to their aryl(halo)silane counterparts. A catalyst system consisting of [(η3-C3H5)PdCl]2 and 2-[2,4,6-(i-Pr)3C6H2]-C6H4PCy2 and use of TBAF⋅3 H2O in THF-H2O are effective especially for the cross-coupling
在DMSO-H 2 O中存在PdCl 2 / PCy 3和氟化四丁基铵(TBAF)的情况下,多种芳基溴化物与三烯丙基(芳基)硅烷的交叉偶联是有效的,以高收率得到各种联芳基。值得一提的是,全碳取代的芳基硅烷对水分,酸和碱稳定,易于获得,可作为其芳基(卤代)硅烷对应物的高度实用替代品。由[(η的催化剂体系3 -C 3 H ^ 5)的PdCl] 2和2- [2,4,6-(我-Pr)3 c ^ 6 ħ 2 ] -C 6 H ^ 4 PCY2和在THF-H 2 O中使用TBAF·3 H 2 O对于与芳基氯的交叉偶联特别有效。两种催化剂体系均能耐受多种常见的官能团。推测反应的高效率归因于用TBAF·3 H 2 O和适量的水处理后烯丙基的易裂解。二烯丙基(二苯基)硅烷还可以与各种芳基溴化物和氯化物交联,收率很高,而烯丙基(三苯基)硅烷只能以中等收率得到交联产物。通过溴氯苯与不同芳基硅烷的顺序交叉偶联,可
ASYMMETRIC BIFUNCTIONAL SILYL MONOMERS AND PARTICLES THEREOF AS PRODRUGS AND DELIVERY VEHICLES FOR PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL AGENTS
申请人:The University of North Carolina at Chapel Hill
公开号:US20170021030A1
公开(公告)日:2017-01-26
Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.
We have disclosed the photophysical and electroluminescent properties of a series of hetero-annulated Ï-conjugated dithieno[3,2-b:2â²,3â²-d]metallole derivatives incorporating Ge, Si, P, and S atoms as a bridging center. The influence of the hetero-annulated structures on their photophysical properties has been investigated systematically by UV/vis and photoluminescence (PL) spectroscopy, transient PL measurements, and DFT calculations. All these compounds show bright fluorescence with high quantum yields both in solutions and in doped thin films with a host matrix. Furthermore, the OLEDs employing the dithienometallole emitters exhibit high external quantum efficiencies of â¼6% at a practical brightness.