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葡萄糖酸钠 | 527-07-1

中文名称
葡萄糖酸钠
中文别名
D-葡萄糖酸盐钠盐;D-葡糖酸单钠盐;2,3,4,5,6-五羟基己酸钠盐;葡糖酸单钠盐;D-葡萄糖酸钠
英文名称
D-Gluconic acid sodium salt, 98%
英文别名
——
葡萄糖酸钠化学式
CAS
527-07-1
化学式
C6H12NaO7
mdl
——
分子量
219.14
InChiKey
IAYLKIVGMOMHDX-JJKGCWMISA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    170-175 °C
  • 比旋光度:
    [α]D20 +11~+13° (c=10, H2O)
  • 溶解度:
    H2O:0.1 g/mL,澄清
  • LogP:
    -3.175 (est)

计算性质

  • 辛醇/水分配系数(LogP):
    -3.87
  • 重原子数:
    14
  • 可旋转键数:
    5
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.83
  • 拓扑面积:
    138
  • 氢给体数:
    6
  • 氢受体数:
    7

安全信息

  • TSCA:
    Yes
  • 安全说明:
    S24/25
  • WGK Germany:
    1
  • 海关编码:
    2918160000
  • 危险品运输编号:
    NONH for all modes of transport
  • RTECS号:
    LZ5235000
  • 危险性防范说明:
    P261,P301+P312,P302+P352,P304+P340,P305+P351+P338
  • 危险性描述:
    H302,H315,H319,H335

SDS

SDS:52ea1ea6753d3d491e1fef06d397f50b
查看

制备方法与用途

葡萄糖酸钠 介绍

葡萄糖酸钠是一种白色或淡黄色的结晶性粉末,易溶于,微溶于醇而不溶于醚。它在多个行业中有着广泛的应用,包括制药、电镀、质处理和食品添加剂等。

化学性质
  • 溶解度:易溶于,微溶于醇,不溶于醚。
  • 生产方法
    • 葡萄糖酸钙加入反应釜,在搅拌下滴加硫酸溶液后静置过滤除去生成的CaSO₄滤渣。浓缩、过滤、干燥,检验合格后包装得成品。
    • 葡萄糖发酵后再用碱中和而得。
    • 加入葡萄糖酸在搅拌下加入稍过量Na₂CO₃溶液中和,在50~60 ℃下搅拌2 h。减压浓缩,冷却结晶、过滤干燥得成品。
应用 医药
  • 用途:营养增补剂,螯合剂,酵母食料。
电镀
  • 用途:在电镀中作光亮剂,单独使用具有使镀液澄清、镀件表面光亮等优点。
质处理 环保与清洗
  • 用途:用作电镀及属清洗的添加剂,也用于质稳定剂。
食品加工 分析方法

精确称取约750mg试样,移入干燥的200ml锥形烧瓶中加冰醋酸75ml,在加热板上溶解后冷却。加入喹哪啶红试液数滴,用0.1mol/L高氯酸冰醋酸溶液经10ml微量滴定管滴定至无色终点。每ml0.1mol/L高氯酸相当于葡萄糖酸钠(C₆H₁₁NaO₇)21.81mg。

安全性
  • ADI:不作特殊规定(以葡萄糖计,FAO/WHO,2001)。
  • GRAS:被FDA认定为一般认为安全(GRAS),编号§182.6757(2000)。
使用限量
  • 以GMP为限(FDA,§182.6757,2000)。

文献信息

  • [EN] PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS CONTENANT DE LA PIPÉRIDINE ET LEURS UTILISATIONS
    申请人:ARRAY BIOPHARMA INC
    公开号:WO2010080864A1
    公开(公告)日:2010-07-15
    A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.
    一种预防和/或治疗代谢性疾病、脑血管疾病等的方法,包括向哺乳动物施用化合物的有效量,其化学式为(I),其中所有符号的含义与规范中定义的相同;其盐、N-氧化物、溶剂合物或前药。以及化学式(I-1)的新化合物:其中所有符号的含义与规范中定义的相同;其盐、N-氧化物、溶剂合物或前药具有抗糖尿病作用和神经保护作用。因此,化合物(I)和化合物(I-1)在预防和/或治疗代谢性疾病如糖尿病、脑血管疾病如中风等方面是有用的。
  • High-Potency Sweetener Composition With Phytoestrogen and Compositions Sweetened Therewith
    申请人:Prakash Indra
    公开号:US20080107776A1
    公开(公告)日:2008-05-08
    The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic, high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic, high-potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as phytoestrogens. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.
    本发明涉及一般性的功能性甜味剂组合物,包括非卡路里或低卡路里的天然和/或合成高效甜味剂,以及制备和使用它们的方法。特别地,本发明涉及不同的功能性甜味剂组合物,包括至少一个非卡路里或低卡路里的天然和/或合成高效甜味剂、至少一个甜味改善组合物和至少一个功能性成分,例如植物雌激素。本发明还涉及功能性甜味剂组合物和方法,可以通过赋予更类似于糖的味道或特性来改善非卡路里或低卡路里高效甜味剂的口感。特别地,功能性甜味剂组合物和方法提供更类似于糖的时间特征,包括甜味的开始和持续时间,以及/或更类似于糖的风味特征。
  • TISSUE DEGENERATION PROTECTION
    申请人:Geuns Joannes
    公开号:US20100099640A1
    公开(公告)日:2010-04-22
    The present invention provides isolated or essentially pure diterpenoic tetrahydropyran, such as steviol-19-glucuronide, steviol, stevioside and rebaudioside processes for obtaining the same and methods for obtaining stable pharmaceutically acceptable salts of the same for use of such compounds or compositions in a treatment of cardiovascular disorders or vascular disease or for the manufacture of medicaments to treat a condition of a cardiovascular disorder or vascular disease.
    本发明提供了分离或基本纯的二萜四氢吡喃类化合物,例如甜菊糖苷-19-葡萄糖醛酸酯,甜菊糖甜菊糖苷和葛根糖苷,以及获得它们的方法和获得这些化合物的稳定的药学上可接受的盐的方法,用于治疗心血管疾病或血管疾病或用于制造治疗心血管疾病或血管疾病症状的药物。
  • NOVEL FUSED HETEROCYCLIC COMPOUND AND USE THEREOF
    申请人:ONO PHARMACEUTICAL CO., LTD.
    公开号:EP1671962A1
    公开(公告)日:2006-06-21
    The compound represented by the general formula (I): wherein, a fused ring AB represents a 5- to 10-membered fused heterocyclic ring; R1 represents (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) an oxo group, (5) an optionally protected hydroxyl group, (6) an optionally protected carboxyl group, (7) an optionally protected amino group, (8) a cyclic group which may have a substituent (s), (9) an aliphatic hydrocarbon group which may have a substituent (s), or (10) an optionally protected thiol group; n represents 0 or an integer of 1 to 8; provided that n represents an integer of not less than 2, plural R1 are the same or different; a salt thereof, a solvate thereof or a prodrug thereof has a kinase(especially c-Jun N-terminalkinase) inhibitory activity and an inhibitory activity of a function of AP-1 as a transcription factor, it is useful as a preventive and/or therapeutic agent for a for example, a diabetes of metabolic disease, etc., a rheumatoid arthritis of inflammatory, etc.
    化合物的一般式(I):其中,融合环AB代表一个5-至10-成员的融合杂环;R1代表(1)氢原子,(2)卤素原子,(3)基,(4)氧基,(5)可选保护的羟基,(6)可选保护的羧基,(7)可选保护的基,(8)可能具有取代基的环状基团,(9)可能具有取代基的脂肪烃基团或(10)可选保护的醇基团; n代表0或1至8的整数; 假设n代表不小于2的整数,则复数R1相同或不同;其盐,溶剂化物或前药具有激酶(尤其是c-Jun N末端激酶)抑制活性和AP-1作为转录因子的功能抑制活性,因此可用作预防和/或治疗代谢疾病(例如糖尿病等)和炎症性风湿性关节炎等的药物。
  • High-Potency Sweetener Composition with Glucosamine and Compositions Sweetened Therewith
    申请人:Prakash Indra
    公开号:US20070116827A1
    公开(公告)日:2007-05-24
    The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as glucosamine. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.
    本发明涉及一般性的功能性甜味剂组合物,包括无热量或低热量的天然和/或合成高强度甜味剂以及制备和使用它们的方法。特别地,本发明涉及不同的功能性甜味剂组合物,包括至少一种无热量或低热量的天然和/或合成高强度甜味剂,至少一种增甜剂组合物和至少一种功能性成分,如葡萄糖胺。本发明还涉及功能性甜味剂组合物和方法,可以通过赋予更像糖的味道或特性来改善无热量或低热量高强度甜味剂的味道。特别地,功能性甜味剂组合物和方法提供更像糖的时间特性,包括甜味的开始和持续时间,和/或更像糖的口味特性。
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