genistein galactoside

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: genistein galactoside
• 英文别名: 5-hydroxy-3-(4-hydroxyphenyl)-7-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
• 化学式: C₂₁H₂₀O₁₀
• 分子量: 432.384
• InChiKey: ZCOLJUOHXJRHDI-JUHPOPGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  尿苷 5’-二二氧磷基半乳糖二钠盐 、 染料木素 在 magnesium(II) chloride hexahydrate 、 glycosyltransferase from Arabidopsis thaliana 作用下， 以 aq. buffer 为溶剂， 反应 3.0h， 生成 genistein galactoside
  参考文献：
  名称：

  Donor substrate flexibility study of AtUGT89C1, a glycosyltransferase from Arabidopsis thaliana

  摘要：

  AtUGT89C1, a glycosyltransferase from Arabidopsis thaliana, has shown interesting characteristics such as accepting diverse NDP-D/L-sugars as glycosyl donors. Genistein was used as a substrate to probe in vitro reactions in which different NDP-sugars were used as sugar donors. Among nine different NDP-D/L-sugars tested, AtUGT89C1 accepted five of them, including UDP--D-glu-cose, UDP--D-galactose, dTDP--L-rhamnose, GDP--L-fucose, and dTDP--2-deoxy-D-glucose and conjugated sugar moieties from the respective donors with the 7-hydroxyl position of genistein. Results showed the promiscuous nature of AtUGT89C1 toward donor and acceptor substrates, thus expanding the biotechnological application of this enzyme in the production of natural and unnatural flavonoid glycosides.[GRAPHICS].

  DOI：

  10.1080/07328303.2016.1251941