双(2-甲氧基乙氧基)甲烷 | 4431-83-8

• 物质功能分类: 有机原料
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 双(2-甲氧基乙氧基)甲烷
• 英文名称: 2,5,7,10-tetraoxaundecane
• 英文别名: 1-methoxy-2-(2-methoxyethoxymethoxy)ethane
• CAS: 4431-83-8
• 化学式: C₇H₁₆O₄
• mdl: MFCD00043945
• 分子量: 164.202
• InChiKey: QWRBKBNCFWPVJX-UHFFFAOYSA-N

物化性质

• 沸点：
  60°C 1,5mm
• 密度：
  0,995 g/cm3
• 闪点：
  60°C/1.5mm
• LogP：
  -0.69 at 22℃
• 稳定性/保质期：

  在常温常压下保持稳定

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 安全说明：
  S24/25
• 海关编码：
  2901100000
• 危险性防范说明：
  P210,P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P332+P313,P337+P313,P362,P370+P378,P403+P233,P403+P235,P405,P501
• 危险性描述：
  H315,H319,H335
• 储存条件：
  请将药品存放在避光、通风干燥的地方，并密封保存。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Bis(2-methoxyethoxy)methane
Synonyms: 2,5,7,10-Tetraoxaundecane; formaldehyde 2-methoxyethyl acetal

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Bis(2-methoxyethoxy)methane
CAS number: 4431-83-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H16O4
Molecular weight: 164.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

双(2-甲氧基乙氧基)甲烷是一种非常有用的研究化学品。

反应信息

• 作为反应物：
  描述：

  双(2-甲氧基乙氧基)甲烷 在 硫酸 、 sodium carbonate 作用下， 以 乙二醇 为溶剂， 生成 2-Hydroxyaethyl-2'-methoxyaethylformal
  参考文献：
  名称：

  Anodic oxidations. IX. Anodic oxidation of 2-methoxyethanol

  摘要：

  DOI：

  10.1021/ja00788a017
• 作为产物：
  描述：

  乙二醇甲醚 生成 双(2-甲氧基乙氧基)甲烷
  参考文献：
  名称：

  NIKOLIC, NIKOLA A.;GONDA, ELIZABETH;LONGFORD, C. P. DESMOND;LANE, NANCY T+, J. ORG. CHEM., 54,(1989) N1, C. 2748-2751

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING CARBONATE COMPOUND
  申请人：Asahi Glass Company, Limited

  公开号：US20150284314A1

  公开（公告）日：2015-10-08

  The present invention relates to a production process capable of selectively producing various kinds of carbonate compounds without restraint in high yields without using toxic compounds such as phosgene and crown ethers, without producing corrosive gases such as hydrogen chloride as a by-product, and without necessity of removing the chloroform as a by-product by distillation, and to a method for producing a carbonate compound, containing reacting compound (1) with a compound having an OH group in the presence of a metal salt and 0.2 to 4.0 mol of compound (2) per mol of the metal salt to obtain a carbonate compound, in which m is an integer of 1-10, Q is an alkylene group having 1 to 4 carbon atoms, etc, and R 10 and R 11 are alkyl groups having 1 to 5 carbon atoms, etc.

  本发明涉及一种生产过程，能够在高产率下有选择地生产各种碳酸盐化合物，而不使用像光气和冠醚这样的有毒化合物，也不产生像氯化氢这样的腐蚀性气体作为副产品，也不需要通过蒸馏去除氯仿作为副产品，以及一种制备碳酸盐化合物的方法，其中包括在金属盐和化合物（1）的存在下，将化合物（1）与具有羟基的化合物反应，每摩尔金属盐添加0.2到4.0摩尔的化合物（2），以获得碳酸盐化合物，其中m是1-10的整数，Q是具有1到4个碳原子的烷基基团，R10和R11是具有1到5个碳原子的烷基基团等。
• LATENT CURING AGENT AND CURABLE POLYURETHANE COMPOSITION
  申请人：SIKA TECHNOLOGY AG

  公开号：US20200140599A1

  公开（公告）日：2020-05-07

  A compound of formula (I) having advantageous properties when used as a latent curing agent for compositions containing isocyanate groups, and to compositions containing the compound of formula (I). The compound of formula (I) is odourless, is liquid and has comparatively low viscosity at room temperature and is stable in storage together with isocyanates. It makes possible odourless single-component polyurethane compositions which have good stability in storage, do not produce bubbles when cured in the presence of moisture, and cause no problematic odour emissions, giving a cured elastic material having good mechanical properties, good heat stability, a surprisingly non-adhesive surface and little tendency towards plasticizer migration.

  具有优越特性的化合物，其化学式为（I），在含异氰酸基团的组合物中作为潜在固化剂使用时具有优势，并且包含化合物（I）的组合物。化合物的化学式（I）无味，液态，在室温下粘度相对较低，在与异氰酸酯一起储存时稳定。它使得可能制备无味的单组分聚氨酯组合物，在储存中具有良好稳定性，在存在湿气时固化时不产生气泡，并且不会产生有问题的气味排放，从而获得具有良好机械性能、良好热稳定性、惊人的非粘附表面和少量塑化剂迁移倾向的固化弹性材料。
• Process for the preparation of halogenated ethers
  申请人：Saurefabrik Schweizerhall

  公开号：US05637775A1

  公开（公告）日：1997-06-10

  The invention relates to a process for the preparation of compounds of formula I ##STR1## wherein R is mono- or disubstituted lower alkyl, the substituents being selected from halogen and lower alkoxy, with the proviso that said substituents are not present at the carbon atom of the lower alkyl radical R linking the group R to the remainder of the molecule of formula I; R.sub.1 is hydrogen, lower alkyl, phenyl or phenyl-lower alkyl; and X is chloro or bromo; which comprises reacting an acetal of formula II, ##STR2## wherein R and R.sub.1 are as defined above, with at least one compound of formula R.sub.2 --X, wherein R.sub.2 is hydrogen or X--SO, in which last mentioned case the reaction mixture must contain a catalytically effective amount of N,N-di-lower alkyl-lower alkanoylamide(s) and wherein X is as defined with respect to the compounds of formula I. The compounds of formula I are useful intermediates, suitably for the synthesis of pharmaceutical or fungicidal compounds.

  该发明涉及一种制备式I的化合物的过程 其中R是单取代或双取代的较低烷基，取代基选自卤素和较低烷氧基，但需注意这些取代基不出现在将基团R连接到式I分子的其余部分的碳原子上； R₁是氢、较低烷基、苯或苯-较低烷基；X是氯或溴；包括将式II的缩醛与至少一种式R₂-X的化合物反应，其中R₂是氢或X-SO，在最后一种情况下，反应混合物必须含有N,N-二较低烷基-较低烷酰胺的催化有效量，并且X与式I的化合物相对应。式I的化合物是有用的中间体，适用于合成药用或杀真菌化合物。
• 一种制备双（二甲氧基乙氧基）甲烷的方法
  申请人：深圳市前海博扬研究院有限公司

  公开号：CN110511124A

  公开（公告）日：2019-11-29

  本发明公开了一种制备双(二甲氧基乙氧基)甲烷的方法，涉及化工合成技术领域。所述方法包括步骤：将乙二醇单甲醚与甲醛在酸催化剂的作用下，进行醇醛缩合反应制得双(二甲氧基乙氧基)甲烷；其中，甲醛与乙二醇单甲醚的摩尔比为1:2‑4；所述酸催化剂的用量为0.1‑10％；反应温度为60‑140℃，反应时间为0.5‑24小时。本发明用酸催化乙二醇单甲醚与甲醛反应生成双(二甲氧基乙氧基)甲烷，属于经济反应，产物包括水，不含副产物，且催化剂对设备腐蚀很小，是一种能重复利用催化剂的清洁的双(二甲氧基乙氧基)甲烷合成方法，适宜工业上的连续生产。
• Cobalt‐Catalyzed Direct Aminocarbonylation of Ethers: Efficient Access to α‐Amide Substituted Ether Derivatives
  作者：Le‐Cheng Wang、Bo Chen、Xiao‐Feng Wu

  DOI：10.1002/anie.202203797

  日期：2022.6.7

  A novel cobalt-catalyzed carbonylative coupling of ethers with amines to construct α-carbonylated ethers has been achieved. Alfuzosin, a medicine for treatment of benign prostatic hyperplasia (BPH), can be synthesized by this process straightforwardly.

  已经实现了醚与胺的新型钴催化羰基化偶联以构建α-羰基化醚。阿夫唑嗪是一种治疗良性前列腺增生（BPH）的药物，可以通过这个过程直接合成。